DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and cest-27

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	135/560 - (24%)
Similarity:	217/560 - (38%)	Gaps:	111/560 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRVNATVQSPNCAQF----PE 128
            |.|.|: |::......|..||||.|.....|..||:  :|:.::    ...:..:|.:|    |:
Worm    33 GPIKGV-GYEQEDGSVVEGFLGIPYAEPPIGALRFK--KPVAHR----KWTEPLDCVRFGPRSPQ 90

  Fly   129 LDRL--RLSESRGENVDDCLTLDIYAP-----EGANQLPVLVFVHGEMLFDGGSEEAQPDY---- 182
            .|.|  :...:.|::.:.||:|:::.|     |..:..||:||:||    .|.:..:..:|
Worm    91 NDELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHG----GGFAVHSSSNYGCAS 151

  Fly   183 ----VLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLV 243
                :..|||::|:|||||...||.:...:...||:.|.|...||||:|.|:..|.|:...||:.
Worm   152 IARNLCTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIF 216

  Fly   244 GQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI--DNQPLDTLSTFARLARCPPPSINPS 306
            ||:.|......|.||..:..||.:.|..:|.....:.:  ..|.......|||........ |.|
Worm   217 GQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDD-NDS 280

  Fly   307 AQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPS-------HPAS 364
                            ..|:...:|..|....:|:....|||......|.|:|:       .|.:
Worm   281 ----------------EDLLQFIDQQPLYKIEMGINPKRGFKHSQAGSLYFVPNFDGDFFPKPLN 329

  Fly   365 LATNSSLALPMIIGATKDASAFIV-----SRIYDQLARLQSR--NVSDY---IDVVLRHT----- 414
            .....:..:.::.|.||....|.:     |:..:.:.:...|  ...||   .|.||:..
Worm   330 QLRKEAPKMQIMTGTTKYEGLFFIALGALSKNPEGIKKFMGRIFKECDYGERADDVLQMVYDFYF 394

  Fly   415 --APPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYR-APVINSISQSYRSVPAY 476
              ..|.:|    :..:.:|...|.:.:.             ||..|| |.::..:...     .|
Worm   395 KGVHPKDH----EKNMHQIVKFIGDYSI-------------NYGTYRLANIMTDLQHD-----VY 437

  Fly   477 LYTFDYRGEHHR--FGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNF 539
            .|.|||   |:.  ||.....|||......::....|........|.|..|:.:...:.|.:.||
Worm   438 FYQFDY---HNSAGFGVFRWLLPFLGSTHCTEMRYVLGKGIISKFRPNDNDKKMLHVMTTYFTNF 499

  Fly   540 ATTGVP---NPSSGVWPQATSEYGPFLRFTNNQQSPLELD 576
            |..|.|   |..:|.|.:..|.: ||..|      .::||
Worm   500 AKYGNPNGENQETGEWQKHDSAH-PFRHF------KIDLD 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	135/560 (24%)
		Aes	<146..345	CDD:223730	57/213 (27%)
		RILP-like	<677..>717	CDD:304877
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	135/560 (24%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	51/189 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157297
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850