Protein Alignment Glt and Nlgn3

DIOPT Version :10

• Sequence 1: NP_477504.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_599163.2
• Gene: Nlgn3 / 171297
• RGDID: 621119
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 798
• Identity: 185/798 - (23%)
• Similarity: 283/798 - (35%)
• Gaps: 253/798 - (31%)

  Fly    45 PVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PI 108
            |.| ...|.:.:.:.|.|..|  .:|||          ||:.:||:.|.....|..||...: |.
  Rat    40 PAP-TVNTHFGKLRGARVPLP--SEILG----------PVDQYLGVPYAAPPIGEKRFLPPEPPP 91

  Fly   109 GYQGRVNATVQSPNCAQ-----FPELDRLRLSESRGENVD-----------DCLTLDIYAP---- 153
            .:.|..|||...|.|.|     .||   :.|......|:|           |||.|::|.|
  Rat    92 SWSGIRNATHFPPVCPQNIHTAVPE---VMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDV 153

  Fly   154 --------------------EGANQ---------------------LPVLVFVHGEMLFDG---- 173
                                .||.:                     .||:|::||....:|
  Rat   154 KRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNM 218

  Fly   174 --GSEEAQPDYVLEK--DVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFG 234
              ||       ||..  :|:::::|||:...||||.......||..|.|...||.|:..|:..||
  Rat   219 IDGS-------VLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFG 276

  Fly   235 GNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCP 299
            |:..::|:.|...||:....|:||..:..|||:.|:|||:||:.:.::.||:...|..|....|
  Rat   277 GDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGC- 340

  Fly   300 PPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDP-----LGFLP 359
                  :......:.|||.:....:||.  :.:.....|:....:....::..||     .|...
  Rat   341 ------NVLDTVDMVDCLRQKSAKELVE--QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFL 397

  Fly   360 SHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVV---------LRHTA 415
            ::...|..|....|..:.|.. |....:....:|.       :||:::|.:         ||.|.
  Rat   398 NYDIMLGVNQGEGLKFVEGVV-DPEDGVSGTDFDY-------SVSNFVDNLYGYPEGKDTLRETI 454

  Fly   416 PPSEHRLWKQWALRE-----------IFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQS 469
                ..::..||.|:           :||       ..|.|.|.::....:..|.:
  Rat   455 ----KFMYTDWADRDNPETRRKTLVALFT-------DHQWVEPSVVTADLHARYGS--------- 499

  Fly   470 YRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDR-------- 526
                |.|.|.|     :|....|..|.  ..||:..|:..|:|..|    .:.|.|.
  Rat   500 ----PTYFYAF-----YHHCQSLMKPA--WSDAAHGDEVPYVFGVP----MVGPTDLFPCNFSKN 549

  Fly   527 --SLSRALVTMWVNFATTGVPNPSSGVWPQAT---------------SEYGP----FL------R 564
              .||..::|.|.|||.||.||...   ||.|               |:|.|    :|      |
  Rat   550 DVMLSAVVMTYWTNFAKTGDPNKPV---PQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPR 611

  Fly   565 FTNNQQSP-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPITTTTTTTTT------TTTTSRP 618
            ..::.::.     ..|.||    :|..:....|..||...||..||.::..|      |.:|.||
  Rat   612 VRDHYRATKVAFWKHLVPH----LYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRP 672

  Fly   619 YAYNPYANWQNRPSQQHPNWH---PADPEYVRAQEARQQEF--------------------IRER 660
            .....|:| :|.|.    :|:   .|.|..|........|.                    :..|
  Rat   673 AISPAYSN-ENAPG----SWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYR 732

  Fly   661 EQRRREQQLRDQQRYPQQ 678
            :.:||::.||  |..||:
  Rat   733 KDKRRQEPLR--QPSPQR 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_477504.1	COesterase	58..579	CDD:395084	151/655 (23%)
		Casc1_N	681..>717	CDD:464947
Nlgn3	NP_599163.2	COesterase	40..624	CDD:395084	152/661 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	169..195		2/25 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	645..691		14/50 (28%)