DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and COEAE1A

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_321362.2	Gene:	COEAE1A / 1281451	VectorBaseID:	AGAP001723	Length:	573	Species:	Anopheles gambiae

Alignment Length:	602	Identity:	150/602 - (24%)
Similarity:	227/602 - (37%)	Gaps:	147/602 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP 107
            |.||..||:     |...::.:| .||:.|.:....:. ....:|.||.|.....|..||:...|
Mosquito    25 LPPVSSQSD-----PTRPIIDSP-TGQVQGTTESCGLF-CTYYSFKGIPYAEPPVGSLRFRNPVP 82

  Fly   108 -IGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEGANQLPVLVFVH--GEM 169
             ..:.|..:.:.....|.|...:.    .:.||.  :|||.|:||..:.....||:|::|  |..
Mosquito    83 RARWTGVRDGSNHGSECLQVSVVP----GQVRGG--EDCLYLNIYTQQLVGLRPVMVWIHGGGYS 141

  Fly   170 LFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFG 234
            :..|.|.:..|:.:::.:||||::||||...||||.......||..|.|...||.|::.|:..||
Mosquito   142 INSGNSVDFGPEKLVQDNVLLVTLNYRLGALGFLSTGDRYAAGNWGLKDCLQALRWVRSNIAAFG 206

  Fly   235 GNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQP---LDTL------- 289
            |:...||:.|.:.||.|.|.|.|:.....||.:.|.||.|||.||....:|   .|.:
Mosquito   207 GDPNSVTIFGNSAGAALVHLLVLTDAGAGLFHRAIAQSSTALVPYAFQTRPRFYADRIASALGFG 271

  Fly   290 ---STFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVV 351
               ||:....|..|      |:...|..:....:|..:.:.
Mosquito   272 TDSSTYVERLRTVP------AEQFVPFQEATVTIPVPRFLR------------------------ 306

  Fly   352 GDPLGFLP--------------SHPASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRN 402
              ||.|.|              ..|..|....:..:|.::|.|....||..:
Mosquito   307 --PLDFGPVVEPGDAPDEVIVRQRPIELIRTGAHRVPFLVGYTDLEGAFFTA------------- 356

  Fly   403 VSDYIDVVLRHTAPPSEHRLWKQWALREIFTP----IQEQTASLQTVAPGLLE-------LSNYI 456
            :.:.||..::.....:.|          :|.|    :...||:...::....|       |...:
Mosquito   357 LDNAIDPTVKGQFNANPH----------LFVPFFWNVGAGTAASSQISGAFREHYWQSRPLDASL 411

  Fly   457 LYRAPVINS-------ISQSYR------SVPAYLYTFDYRGEHHRFGHLSNPLPFGVD---ASLS 505
            .|...|..|       |.|:.|      ..|.|.|.|.|.|:.:.:..|     |||.   |..:
Mosquito   412 DYEWTVYQSDHMFAFAIDQTVRLHAQTTPAPLYYYQFAYDGDLNLYKKL-----FGVQHPGAIHT 471

  Fly   506 DDSVYLFPYPPEASRLNPLD-----RSLSRALVTMWVNFATTGVPNPSSGV------WPQATSEY 559
            |:..|||..|  |:.|.|:.     .::|..:|.||.|||.||.|.|....      ||...:..
Mosquito   472 DELPYLFHIP--AAMLVPVSPDSHANTVSSRVVRMWTNFARTGNPTPGQDALLQNVQWPTVGATG 534

  Fly   560 GPFLRFTNN----QQSP 572
            ..:|...::    ||:|
Mosquito   535 TGYLSIGHDLLPVQQTP 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	145/590 (25%)
		Aes	<146..345	CDD:223730	63/213 (30%)
		RILP-like	<677..>717	CDD:304877
COEAE1A	XP_321362.2	COesterase	34..559	CDD:278561	145/588 (25%)
COEAE1A	XP_321362.2	Aes	<129..>236	CDD:223730	40/106 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910