DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and AgaP_AGAP011366

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_317954.4	Gene:	AgaP_AGAP011366 / 1278331	VectorBaseID:	AGAP011366	Length:	580	Species:	Anopheles gambiae

Alignment Length:	534	Identity:	160/534 - (29%)
Similarity:	269/534 - (50%)	Gaps:	41/534 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 YAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQA---AQPIGYQGRVN 115
            ::...:.:|..|.:|::.|..........||..||.:||.....|..||:|   |||  ::|..:
Mosquito    34 FSNDPDPIVDLPGLGKLKGSYTKTAWTGAPVQQFLNVRYAEPPVGKNRFKAPIPAQP--WEGIQD 96

  Fly   116 ATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEGANQLPVLVFVHGEMLFDGGSEEAQP 180
            .:|:......:.:|.:|...:.:..|::||::|.:|..:...:.||.|::||...:.|.:.:..|
Mosquito    97 VSVRGQGAPCYGDLKKLPKDQLKSSNLEDCISLCVYTKDTTAKRPVAVYIHGGGFYSGSAAQHPP 161

  Fly   181 DYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQ 245
            :|:||||::||...|||...||:|..|:.:|||.|:.|:.||.||:|:::.||||:..|||.:||
Mosquito   162 EYLLEKDIVLVVPQYRLGALGFMSTKTETIPGNAAIMDVLLAFEWVQKHIEHFGGDPSQVTAIGQ 226

  Fly   246 AGGATLAHALSLS-GRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQG 309
            :.||.:..:|..| ....:.||::||.||.|...:..|:.........||.|     ..:|.|.
Mosquito   227 SAGAGILSSLLFSPALKESYFQKIILHSGAAFGSWQFDHNGERNARDIARRA-----GFDPKAP- 285

  Fly   310 LKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASL--ATNSSLA 372
            |:.:.:.|..:.|..|:.||.....|..|.|:...|| ::.:|.|....|..|..:  |......
Mosquito   286 LEQVEEFLLDVDTYTLLKAFMHHNWQGLHKGINNTGG-RMTIGGPSQLFPKTPYEVMKAGGGRKN 349

  Fly   373 LPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPI-- 435
            :||:.|..||...|.:..::..|:.|:..:..|:    ||:.......|:.....:....||:
Mosquito   350 IPMLTGVVKDEGTFALVDVFTILSALKLHDKKDF----LRYDVIEDIQRILGTVEVSCSVTPLAV 410

  Fly   436 -----QEQTAS--LQTVAPGLLELSNYILYRAPVINSISQSYRSVP--AYLYTFDYRGEHHRFGH 491
                 .|..|:  :..:.|||::|....|.::.|:.....:.|..|  .::|:|||||||.|||:
Mosquito   411 KSMLDMEAAANGDILKMVPGLIDLCGMHLIKSSVLRLAQYNSRHTPDRTFVYSFDYRGEHTRFGY 475

  Fly   492 ---LSNPLPFGVDASLSDDSVYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPN----PSS 549
               :|: :||......::|.:|||||||.|::||..|.::::.:|.:|.:|...|||.    |.
Mosquito   476 DQDISH-IPFDGGVHHTNDLLYLFPYPPTAAQLNEPDTAMAKKMVDLWTSFIVEGVPKSCDLPH- 538

  Fly   550 GVWPQATSEYGPFL 563
              ||.....:||::
Mosquito   539 --WPAFNQIFGPYV 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	160/533 (30%)
		Aes	<146..345	CDD:223730	68/199 (34%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP011366	XP_317954.4	Abhydrolase	37..554	CDD:304388	160/531 (30%)
AgaP_AGAP011366	XP_317954.4	Aes	<137..>237	CDD:223730	42/99 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0005921
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020