DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and COEAE8O

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_316734.4	Gene:	COEAE8O / 1277285	VectorBaseID:	AGAP006700	Length:	598	Species:	Anopheles gambiae

Alignment Length:	585	Identity:	142/585 - (24%)
Similarity:	234/585 - (40%)	Gaps:	111/585 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 KPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP- 107
            |.|...|:.....|...:....:.|.:.|:. .|....:....|.|:.|.....|..||::..|
Mosquito    12 KNVSTGSDAEKHMPITRICVQVQQGSVYGVR-DKLPNGQSYYYFKGVPYAKAPVGALRFKSPAPL 75

  Fly   108 ----IGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAP-----EGANQLPVLV 163
                :.|   ::.|.:..||.....|.:    |..|.  :|.|.|:||.|     :....|||:|
Mosquito    76 EKFAVSY---LDCTRERSNCLGLDVLTK----EISGS--EDGLFLNIYTPKLGKRDDPEPLPVMV 131

  Fly   164 FVHGEMLFDGGSEEA--QPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWL 226
            |:||..|..|..:.:  .|:|::::.|::|::||||...|||......:.||..|.|.:.||.|:
Mosquito   132 FIHGGGLIGGHGDSSLYLPNYLVQEGVIVVTLNYRLGVLGFLCLPDAGIEGNAGLKDQRAALRWI 196

  Fly   227 QRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLST 291
            ..|:..|||:|..|||.|.:.||...:...||..:...|.:.|||||:....:....||.:....
Mosquito   197 SENIGVFGGDASNVTLFGASSGAIAVNFHCLSPESKRYFHKAILQSGSIYTEFAFQEQPEEKARR 261

  Fly   292 FARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKL----VV- 351
            .|:|.     ..:|:..|  .:|:.|...|..:|. ..:.|:|......:.:|  |::    |:
Mosquito   262 LAKLL-----GHSPATDG--EVYEILRAAPARKLF-ELQPLVLTEREKAVERL--FQIPFLPVIE 316

  Fly   352 --GDPLGFLPSHPAS-LATNSSLALPMIIGAT-KDASAFIVSRIYDQLARLQSRNVSDYIDVVLR 412
              ..|...:..||.. |:..:|:.:|:|:|.. :|....::                |.|..:..
Mosquito   317 RSDSPDALITRHPTEILSEPNSMDIPIILGYNERDGMMVLI----------------DAIKTLAA 365

  Fly   413 HTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLL----ELSNYILYRAPV----INSISQS 469
            :.|.|            |.|.|   :|.:|...:|...    |:..:.....||    :|.::..
Mosquito   366 YNAEP------------ERFIP---RTVALDYFSPEARALGEEIREFYFGARPVCRDTLNQLTDV 415

  Fly   470 Y--RSVPAYLYTFDYRGEHHR----FGHLSNPLPFGVDASLS-----------------DDSVYL 511
            :  :.:.||..|.:....|.|    ||:     .|..|..|:                 |:..||
Mosquito   416 FTDKYLLAYRMTVELWARHQRRSKFFGY-----RFAFDGLLNKGKAIMSLGTMKGAAHIDEVYYL 475

  Fly   512 FPYPPEASRLNPLDRS--LSRALVTMWVNFATTGVPNPSS-GVWPQATSEYGPFLRFTNNQQSPL 573
            |..|...:.:...||:  |.:.:|.:|.|||..|.|.|:. ...|.....:.|.....::|..||
Mosquito   476 FSSPLLRTEVPETDRAYGLRKTMVRLWSNFARYGEPTPAQPAPDPVVPFRWEPQPNVPDSQDVPL 540

Fly 574 573
Mosquito 541 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	139/574 (24%)
		Aes	<146..345	CDD:223730	63/205 (31%)
		RILP-like	<677..>717	CDD:304877
COEAE8O	XP_316734.4	Abhydrolase	31..564	CDD:304388	138/566 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920