DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and AgaP_AGAP006228

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_316296.3	Gene:	AgaP_AGAP006228 / 1276889	VectorBaseID:	AGAP006228	Length:	540	Species:	Anopheles gambiae

Alignment Length:	538	Identity:	144/538 - (26%)
Similarity:	244/538 - (45%)	Gaps:	94/538 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AFLGIRYGTVGGGLARFQ-AAQPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLD 149
            :|.||.|.....|..||: ...|..:...::.|.|...|..|   || |:::..|.  :|.|.|:
Mosquito    30 SFQGIPYAKPPVGELRFKDPTPPENWTQVLDCTEQCDPCFHF---DR-RVNKIVGS--EDSLRLN 88

  Fly   150 IYAP--EGANQLPVLVFVHGEMLFDG--GSEEAQPDYVLEKDVLLVSINYRLAPFGFL--SALTD 208
            |::.  :....|||:|:::|....:|  |:|...|||::|||::||::|||:...|||  .:.|.
Mosquito    89 IFSKTIKPTKPLPVMVYIYGGGFVEGTSGTELYGPDYLIEKDIVLVTLNYRVGALGFLCCQSPTA 153

  Fly   209 ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVG-QAGGATLAHALSLSGRAGNLFQQLILQS 272
            .:|||..|.|.:|||.|::.|:..|||:...:||.| .||||::.:. :::..:.||||:.|:.|
Mosquito   154 GVPGNAGLKDQRLALRWVRDNIASFGGDPSAITLFGHSAGGASVQYH-TIADASKNLFQRAIIMS 217

  Fly   273 GT-----ALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQL 332
            |:     ||.|.  .|.|       .:||:    :|....:|.:.......|..:.:.:...::.
Mosquito   218 GSTMCSWALTPQ--RNWP-------EKLAK----AIGWQGEGDEEAALQYLRQASPESIVDHQEK 269

  Fly   333 LLQNEHLGLTQLGGFKLVVGDP----LGFLPSHPASLA-TNSSLALPMIIGATKDASAFIVSRIY 392
            |...:.:....|..|...: :|    :.|:|..|..:: |....::.::||.|.:....::.::.
Mosquito   270 LFGPQEIQEGLLSPFAPTI-EPYESEVCFIPRSPFEMSRTAWGNSIDIMIGGTSEEGLILLPKVK 333

  Fly   393 DQL-ARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLL------ 450
            .|| :.||...:  ::..|..|.....|.|:.....|::::.|  :...|:..: .|.:
Mosquito   334 PQLPSMLQDPRL--FVGNVPFHLKLSLEQRMAFGEQLKQLYYP--DSNPSIDNL-DGFVNMASDR 393

  Fly   451 ----ELSNYILYRAPVINSISQSYRSVPAYLYTFDYR-------GEHHRFGHLSNPLPFGVDASL 504
                :|...||.||        :|.....   ||.||       ..|:|. |:.:|...|  .|.
Mosquito   394 IFWHDLHRTILARA--------NYACTAK---TFVYRFCVDSPFFNHYRI-HMVDPNARG--TSH 444

  Fly   505 SDDSVYLFPYPPEASRL--NPLDRSL--SRA---LVTMWVNFATTGVPNPSSGV---WPQATSEY 559
            :|:..|||      |.:  .|||:|.  .||   ||.::.:|||...||..|..   |.......
Mosquito   445 ADEISYLF------SNIFAKPLDKSTLEYRAIQHLVDIFTSFATNSDPNCDSTASLSWTAVPKTA 503

  Fly   560 GPF--LRFTNNQQSPLEL 575
            .|:  |..:|:....:||
Mosquito   504 PPYNCLNISNDGVEVVEL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	144/538 (27%)
		Aes	<146..345	CDD:223730	64/210 (30%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP006228	XP_316296.3	COesterase	2..530	CDD:278561	144/538 (27%)
AgaP_AGAP006228	XP_316296.3	Aes	83..>194	CDD:223730	44/110 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910