DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and AgaP_AGAP006227

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_316295.4	Gene:	AgaP_AGAP006227 / 1276888	VectorBaseID:	AGAP006227	Length:	542	Species:	Anopheles gambiae

Alignment Length:	593	Identity:	152/593 - (25%)
Similarity:	245/593 - (41%)	Gaps:	143/593 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQ----AAQPIG------ 109
            :||...|. ..:.|.:.|:.  ||.|.       |:.|       ..||    ...|||
Mosquito     2 SQPDHPVA-VTQYGPVRGVK--KTAAT-------GVEY-------LNFQRIPYCKPPIGERRFKD 49

  Fly   110 ------YQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPE--GANQLPVLVFVH 166
                  :...::.|.|.|:..||.:|    |::..|.  :|.|.:::|..|  .|...||:|::|
Mosquito    50 LELPEPWTEPLDCTQQGPSGYQFNKL----LNKIVGS--EDHLYMNVYTKELKPAKLRPVMVWIH 108

  Fly   167 GEMLFDG--GSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDEL--PGNVALSDLQLALEWLQ 227
            |.....|  |:|...|||:::||::||:.|||:..|||||..:.||  |||..|.|..:||.|::
Mosquito   109 GGAFMRGSSGTEMYGPDYLIQKDIVLVTFNYRIGAFGFLSLDSKELGIPGNGGLKDQNVALRWVR 173

  Fly   228 RNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTF 292
            .|:..|||:...|||.|::.|....|...:|.::..||::.|:.||..||.:  ...|...::
Mosquito   174 DNIAQFGGDPDNVTLFGESAGGCSVHYHMVSSQSRQLFRRAIVMSGCTLNNW--STAPRRGMA-- 234

  Fly   293 ARLARCPPPSINPSAQGLK-PLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPL- 355
            .|||:    ::..:.:|.: .|...|...|..:::...:.||.:|| |....|..|..|| :|.
Mosquito   235 ERLAK----ALGWNGKGGEAELLKVLRATPAEEIIKHQDLLLTKNE-LENRILFAFGPVV-EPYV 293

  Fly   356 ---GFLPSHPASLATNS-SLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAP 416
               .|:|..|..:...: |..:.::||...:...|.:|.|.:..|.:.:....:|:        .
Mosquito   294 TESTFIPKAPLEMCREAWSNDIDILIGGNAEEGLFCLSSIKESPAIMDNLKNFEYL--------V 350

  Fly   417 PSEHRL------WKQWAL----------------REIFTPIQEQTASLQTVAPGLLELSNYILY- 458
            |:|..|      .:|:.|                ||                 |.|.|....|:
Mosquito   351 PTELELVRGSQACQQYGLKLKKFYYGGSQPSFDNRE-----------------GYLTLMTDKLFW 398

  Fly   459 ---RAPVINSISQSYRSVPAYLYTFDYRGE---HHRFGHLSNPLPFGVDASL-----SDDSVYLF 512
               ...|.:.|| |.:....::|.|....|   |:|.        :..|.::     :||..|||
Mosquito   399 HGLHRTVCSRIS-SQKPAKTFVYRFAVDSETYNHYRI--------YFCDRNVRGTAHADDLSYLF 454

  Fly   513 -----PYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGV---WPQATSEYGPF--LRFTN 567
                 |.|.    :..::....:.||.::.||||.|.||....|   |....::..|:  |...|
Mosquito   455 KNVFSPVPD----VGTMEYRTMQTLVELFTNFATVGSPNVGGSVGDIWQPVGAKVEPYKCLNINN 515

  Fly   568 NQQSPLEL 575
            ...|.::|
Mosquito   516 GGVSFIDL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	152/593 (26%)
		Aes	<146..345	CDD:223730	68/205 (33%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP006227	XP_316295.4	COesterase	3..517	CDD:278561	150/584 (26%)
AgaP_AGAP006227	XP_316295.4	Aes	<90..>195	CDD:223730	44/104 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910