DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and COEJHE4F

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_315860.3	Gene:	COEJHE4F / 1276501	VectorBaseID:	AGAP005836	Length:	571	Species:	Anopheles gambiae

Alignment Length:	553	Identity:	138/553 - (24%)
Similarity:	242/553 - (43%)	Gaps:	105/553 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AFLGIRYGTVGGGLARFQAAQPIG-YQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLD 149
            |||||.:.....|..||...||.. :.|:.:||.....|.|...|  :.::...|:  :|||.::
Mosquito    60 AFLGIPFAKPPIGKLRFANPQPNDPWTGKYDATKAKDACIQMITL--VPMAPLFGK--EDCLYIN 120

  Fly   150 IYAP----EGANQLPVLVFVHGEMLFDGGSEEAQPD---YVLEKDVLLVSINYRLAPFGFLSALT 207
            ::.|    ..|..|||:|::||.....|.::..|.|   ::..:.|::|:..|||..|||||...
Mosquito   121 VFVPALEVRDAGLLPVMVYIHGGGFLYGSAQTEQRDPARFMTSRRVIVVTFQYRLGVFGFLSTGD 185

  Fly   208 DELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQS 272
            ...|||..:.|..:||.|:::|:..|||:...||:.|::.|.:......||..:..||.:.:..|
Mosquito   186 RAAPGNFGMKDQVMALRWVKKNIRAFGGDPNLVTIFGESAGGSSVQFQMLSPLSRGLFHRAVSMS 250

  Fly   273 GTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNE 337
            |:|::.:.:   |::.....||........::.|....:.|.:.|..:...:|..:.|:|.|.:.
Mosquito   251 GSAISSWSV---PIENPLMLARAQAKVLGIVDASELSTEELVEQLREVDAVELTRSTERLKLWDI 312

  Fly   338 HLGLTQLGGFKLVV---GDPLGFLPSHP-ASLATNSSLALPMIIGATKDASAFIVSRIY------ 392
            |    .:..:..||   .:|..||...| |:....:...:|.:.|:..:..:.:...||
Mosquito   313 H----PITLYHPVVEPPEEPEPFLAEDPRAAWRRGAYATVPWMTGSIPNDGSIVTQTIYRNDSLV 373

  Fly   393 ---------------------DQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQ 436
                                 ::||||:.|        .|::| |||      :|..::.:..|.
Mosquito   374 GDLNSKFVNLLPLILRTSITKEKLARLRKR--------FLKNT-PPS------KWITKDNYAEIT 423

  Fly   437 EQTASLQTVAPGLLELSNYILYRAPVINSISQSYRS---VPAYLYTFDYRGEHHRFGHL--SNPL 496
            :            |....:.||  |::.||.|.:.|   .|..:|:|.:|| .:.|..|  ....
Mosquito   424 K------------LMSEAWFLY--PMVRSIKQHHASRKHTPTSVYSFQFRG-RYSFSKLYTGTDT 473

  Fly   497 PFGVDASLSDDSVYLFPYP---PEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGVWPQATSE 558
            |:|:  :.:|:.:|||..|   ||....:| :..:::..|..:|:|||..:.:       :..:.
Mosquito   474 PYGI--THADEMIYLFRMPLLFPEFPPGSP-EAEMTQLWVKFFVDFATHDIVD-------KVGTC 528

  Fly   559 YG---PFLRF--TNNQQSPL--ELDPHFGEGIY 584
            ||   ..:.|  |||:..|:  .|.|...|.:|
Mosquito   529 YGEKCEVMTFANTNNRYFPVSKRLVPGLDEEMY 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	136/546 (25%)
		Aes	<146..345	CDD:223730	55/205 (27%)
		RILP-like	<677..>717	CDD:304877
COEJHE4F	XP_315860.3	COesterase	33..564	CDD:278561	138/553 (25%)
COEJHE4F	XP_315860.3	Aes	53..>227	CDD:223730	55/170 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920