DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and AgaP_AGAP005756

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_315770.4	Gene:	AgaP_AGAP005756 / 1276426	VectorBaseID:	AGAP005756	Length:	579	Species:	Anopheles gambiae

Alignment Length:	614	Identity:	154/614 - (25%)
Similarity:	245/614 - (39%)	Gaps:	106/614 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKPLL-----LVLALCGAQVHAHSVGLRPDYNDYSDEDTRRDWLPEPLKPVPWQSETRYAQPQEA 60
            |:|.|     |::.|....::...:||||        .|..|.....|.|
Mosquito     1 MQPFLAAILRLLVGLLKTWLYRVWLGLRP--------PTSNDCCTVTLGP--------------- 42

  Fly    61 VVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPI-GYQGRV-NATVQSPNC 123
                   |::.|::...|...| .:||.||.|.....|..|||.|.|: .:|..| ...|:...|
Mosquito    43 -------GKVRGLTKVTTGGTR-YHAFKGIPYAVPPLGDRRFQPAVPLESFQTPVLECFVERSKC 99

  Fly   124 AQFPELDRLRLSESRGENVDDCLTLDIYAP-----EGANQLPVLVFVHGEMLFDGGSEEA---QP 180
            .|:.:|..:.:..      :|.|.|::|.|     :.....||:|::||.. |..||.:|   .|
Mosquito   100 LQYDQLLNVLVGS------EDGLFLNVYTPALTGNDSCGLFPVMVYIHGGG-FLSGSGDAFLYDP 157

  Fly   181 DYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQ 245
            .:.:|:.|::|:.||||.|.||||.....:.||..|.|..|.|:|::.|:..|||:...|||.|:
Mosquito   158 VHFMEQRVVIVTFNYRLGPLGFLSLPKAGIEGNAGLKDQLLVLQWIRNNIGKFGGDPENVTLFGE 222

  Fly   246 AGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGL 310
            :.||..|:...||..:...|.::|.|||.|.:......:|.:..   .:||:|    :.......
Mosquito   223 SAGAKAAYLHYLSPVSRKYFHRVICQSGVACSDLAFQVEPSEKA---RKLAKC----VGYEGSSD 280

  Fly   311 KPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVV--GDPLGFLPSHPA-SLATNSSLA 372
            :...|.|.:.|..:|.......|..:|.....|. .|:.|:  ..|...:..||. :|.|.....
Mosquito   281 QEALDMLLKTPAKELFKHQLATLTDSERHEELQF-PFRPVIERPHPGAIVLQHPLDALQTELDPP 344

  Fly   373 LPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQE 437
            :|:|.|.........:::....||...: :....:..:||..|..::  |.|:  :::.:...:.
Mosquito   345 IPLITGCNSGEGMIALAKAQHHLAEYNA-HPERLLPPMLRLHANAND--LGKK--VKQFYFQTRP 404

  Fly   438 QTASLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPF---- 498
            .|:.:......:|..:.|::........:::....|..|.|.|.:.|   |:|:|...|..
Mosquito   405 ITSDMLPELMDVLSDNEYVMATVTAAELVAKFQPKVKHYCYYFTHDG---RWGNLKRLLNMYHLP 466

  Fly   499 GVDASLSDDSVYLFPYPPEASRLNPLDR-SLSRALVTMWVNFATTGVPNPSSG-----------V 551
            ||  ...||..|:|.....||.....|. .:.:|.|.||.|||..|.|.|..|           |
Mosquito   467 GV--CHGDDVFYMFSSALNASLPGDADEVCVRQAFVRMWSNFAHRGDPTPDEGDLAEGLVRWEPV 529

  Fly   552 WPQATSEY----------------GPFLR 564
            .|.|...|                .|||:
Mosquito   530 EPCAGKSYFKLRCLQIDRSLKMVANPFLK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	141/555 (25%)
		Aes	<146..345	CDD:223730	63/206 (31%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP005756	XP_315770.4	COesterase	31..551	CDD:278561	142/567 (25%)
AgaP_AGAP005756	XP_315770.4	Aes	<120..>226	CDD:223730	39/106 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910