DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and AgaP_AGAP006727

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_309018.4	Gene:	AgaP_AGAP006727 / 1270333	VectorBaseID:	AGAP006727	Length:	556	Species:	Anopheles gambiae

Alignment Length:	538	Identity:	146/538 - (27%)
Similarity:	229/538 - (42%)	Gaps:	120/538 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 AFLGIRYGTVGGGLARFQAAQPIGYQGRVNATVQSPNCAQFPELD---RLRLSESRG------EN 141
            ||.||.|.....|..||:|.||:.         :.|    :|.||   ...:..||.      |.
Mosquito    31 AFRGIPYAKPPVGELRFRAPQPLD---------RFP----YPVLDCSVERDVCFSRNMFTQELEG 82

  Fly   142 VDDCLTLDIYAP---EGANQ-LPVLVFVH-GEMLFDGGSEEA-QPDYVLEKDVLLVSINYRLAPF 200
            .:|||.|::|.|   |.|.| |||:||:| |..||..|:.:. .|:|:|:::|::|::||||...
Mosquito    83 SEDCLHLNVYTPGAGEKAGQPLPVMVFIHGGAFLFGSGNGDCYSPEYLLQEEVIVVTLNYRLGAL 147

  Fly   201 GFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLF 265
            |||...:..:.||..|.|....|.|:|:|:..|.|:...|||.|::.||...|...||..:...|
Mosquito   148 GFLHLPSQGIEGNAGLKDQLAVLRWVQQNIAAFNGDPHNVTLFGESAGAASVHLHMLSPVSRQYF 212

  Fly   266 QQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFE 330
            .:.|.|||.::..:::....::...:.||       .|:|.|:..:.:|..|.....:||:....
Mosquito   213 HRAICQSGASVMEWVMQRDSINRTRSLAR-------HIDPDAKTDEQVYRTLLAADKAQLMGLML 270

  Fly   331 QLLLQNE-HLGLTQLGGFKLVVGD----PLGFLPSHP--ASLATNSSLALPMIIGATKDASAFIV 388
            ..|..:| ..||..  .||.||.:    |...:|.||  |....:.:..:|:|.| ..|....|:
Mosquito   271 HTLSADEKRRGLPM--PFKPVVEEGEPGPDTVVPVHPFVAMQQRDRTGTMPIIFG-NNDREGTIM 332

  Fly   389 SR-------IYD-QLARLQSRNVSDYIDVVLRHTAPPSEHRLWKQWALREIFTPIQEQTASLQTV 445
            ..       :|| .:||:..|.|         :.||.|.       |..::.:.:::.....|.|
Mosquito   333 MMDAIKKLDLYDNDMARMIPRTV---------NVAPGSA-------ACEQLASEVKQFYCGAQGV 381

  Fly   446 APGLLELSNYIL-----YRAPVI-NSISQSYR----SVPAYLYTFDYRGE---HHRFGHLSNPLP 497
            ..   |.:|.:.     |...:: |:.::.:.    :.|.:.|.|.|.||   :.:...||.|
Mosquito   382 TK---ETANQLADLMTDYHFGILANTCAELHARYQPNSPMFYYQFSYDGELNMYKKLLQLSIP-- 441

  Fly   498 FGVDASLSDDSVYLF----------PYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSG-- 550
               .|..:|:..|||          | ..||.|:..|       :..:|.|||..|.|.|::.
Mosquito   442 ---GACHADELSYLFLMRLANYDVKP-DTEAGRVRQL-------MCRLWTNFAKHGHPTPANDES 495

  Fly   551 ----------VWPQATSE 558
                      :.|.|.||
Mosquito   496 LPFRWQPVDKIAPSAASE 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	146/538 (27%)
		Aes	<146..345	CDD:223730	66/205 (32%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP006727	XP_309018.4	COesterase	9..505	CDD:278561	142/528 (27%)
AgaP_AGAP006727	XP_309018.4	Aes	<91..>205	CDD:223730	44/113 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920