DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and Ces1g

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	551	Identity:	151/551 - (27%)
Similarity:	227/551 - (41%)	Gaps:	116/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILG----ISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQPIGYQGRV-NATVQSPNCAQFP 127
            |::||    :.|.    ::||..|||:.:.....|..||...:|......| :.|...|.|.|.|
Mouse    31 GKVLGKYVTLEGF----SQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYPPLCYQNP 91

  Fly   128 ELDRLRLSE--SRGENV------DDCLTLDIYAPEGANQ---LPVLVFVH-GEMLFDGGSEEAQP 180
            |. .|||:|  :....:      :|||.|:||.|....|   |||:|::| |.::.||.|.....
Mouse    92 EA-ALRLAELFTNQRKIIPHKFSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVIDGASTYDGV 155

  Fly   181 DYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQ 245
            ...:.::|::|.|.|||..:||.|...:...||....|...||.|:|.|:.:||||.|.||:.|:
Mouse   156 PLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGE 220

  Fly   246 AGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARCPPPSINPSAQGL 310
            :.|......|.||..|.|||.:.|.||....||.|           |.|.||       |.|:.:
Mouse   221 SAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCL-----------FGRAAR-------PLAKKI 267

  Fly   311 KPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLG-----GFKLVVGDPLG------------FL 358
            ..|..|  :..||   ||....|.|.....|.::.     |....:|||..            .|
Mouse   268 AALAGC--KTTTS---AAMVHCLRQKTEDELLEVSLKMKFGTVDFLGDPRESYPFLPTVIDGVLL 327

  Fly   359 PSHPAS-LATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDVVLRHTAPPSEHR- 421
            |..|.. ||..|...:|.::|..|....:|:....|                     .|.||.:
Mouse   328 PKAPEEILAEKSFNTVPYMVGINKHEFGWIIPMFLD---------------------FPLSERKL 371

  Fly   422 --------LWKQWALREIF-----TPIQEQ---TASLQTVAPGLLELSNYILYRAPVINSISQSY 470
                    ||:.:.:..|.     ..|::.   |....|:....|:|...|::..|.: .:|:|:
Mouse   372 DQKTAASILWQAYPILNISEKLIPAAIEKYLGGTEDPATMTDLFLDLIGDIMFGVPSV-IVSRSH 435

  Fly   471 R--SVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDD--SVYLFPYPPEASRLNPLDRSLSRA 531
            |  ..|.|:|.:.||.     ..:|:..|..:....:|:  ||:..|:..|.:....:  :||:.
Mouse   436 RDAGAPTYMYEYQYRP-----SFVSDDRPQELLGDHADELFSVWGAPFLKEGASEEEI--NLSKM 493

  Fly   532 LVTMWVNFATTGVPNPSSGV--WPQATSEYG 560
            ::..|.|||..|.|| ..|:  ||:...:.|
Mouse   494 VMKFWANFARNGNPN-GEGLPHWPEYDQKEG 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/551 (27%)
		Aes	<146..345	CDD:223730	69/202 (34%)
		RILP-like	<677..>717	CDD:304877
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	151/551 (27%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	43/117 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850