DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Nlgn2

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_446444.1	Gene:	Nlgn2 / 117096	RGDID:	621118	Length:	836	Species:	Rattus norvegicus

Alignment Length:	669	Identity:	177/669 - (26%)
Similarity:	249/669 - (37%)	Gaps:	191/669 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQ--- 125
            |::.|:  .:.:.|.   ||..|||:.|.|...|..|||..: |..:.|..|||...|.|.|
  Rat    49 GRVRGV--RRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLH 111

  Fly   126 --FPEL-------DRLRLSESRGEN-VDDCLTLDIYAP----------------------EGANQ 158
              .|.:       |.|..:.:..:| .:|||.|::|.|                      ..:.:
  Rat   112 GALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDSGK 176

  Fly   159 LPVLVFVHGEM-------LFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVAL 216
            .||::|:||..       :|||....|.      .:|::.::||||...||||.......||..|
  Rat   177 KPVMLFLHGGSYMEGTGNMFDGSVLAAY------GNVIVATLNYRLGVLGFLSTGDQAAKGNYGL 235

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.||..|:.||||:..::|:.|...||:..:.|.||..:..|||:.|.|||||::.:.:
  Rat   236 LDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSV 300

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLV----------AAF------- 329
            :.|||......|....|       ..:......:||.|..:.:||          .||
  Rat   301 NYQPLKYTRLLAAKVGC-------DREDSTEAVECLRRKSSRELVDQDVQPARYHIAFGPVVDGD 358

  Fly   330 ------EQLLLQNEHLGLTQLGGFKLVVGDPLGFLPSHPASLATNSSLALPMIIGATKDASAFIV 388
                  |.|:.|.|.|....|.|..  .|:.|.|:.....|..           |.:..|..|.|
  Rat   359 VVPDDPEILMQQGEFLNYDMLIGVN--QGEGLKFVEDSAESED-----------GVSASAFDFTV 410

  Fly   389 SRIYDQLARLQSRNVSDYID--VVLRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTA 440
            |...|        |:..|.:  .|||.|.    ..::..||.|:           :||
  Rat   411 SNFVD--------NLYGYPEGKDVLRETI----KFMYTDWADRDNGEMRRKTLLALFT------- 456

  Fly   441 SLQTVAPGLLELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLS 505
            ..|.|||.:.....:..|::||             |.|||    .||   ..:...|...||:..
  Rat   457 DHQWVAPAVATAKLHADYQSPV-------------YFYTF----YHH---CQAEGRPEWADAAHG 501

  Fly   506 DDSVYLFPYP-PEASRLNPL-----DRSLSRALVTMWVNFATTGVPNP----------------S 548
            |:..|:|..| ..|:.|.|.     |..||..::|.|.|||.||.||.                .
  Rat   502 DELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFE 566

  Fly   549 SGVWPQATSEYGPFL------RFTNNQQSP-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPI 602
            ..||.:..|:...:|      |..:|.::.     |||.||      |.|.......||...||.
  Rat   567 EVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPH------LHNLHTELFTTTTRLPPY 625

  Fly   603 TTTTTTTTT---TTTTSRP 618
            .|.....|.   |:.|.||
  Rat   626 ATRWPPRTPGPGTSGTRRP 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	164/625 (26%)
		Aes	<146..345	CDD:223730	68/250 (27%)
		RILP-like	<677..>717	CDD:304877
Nlgn2	NP_446444.1	COesterase	42..601	CDD:395084	160/618 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661		8/22 (36%)
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	679..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336467
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840