DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and AgaP_AGAP013509

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	XP_003436330.1	Gene:	AgaP_AGAP013509 / 11175878	VectorBaseID:	AGAP013509	Length:	634	Species:	Anopheles gambiae

Alignment Length:	592	Identity:	148/592 - (25%)
Similarity:	238/592 - (40%)	Gaps:	124/592 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 AQPQEAVV-----QAPEV----------GQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQA 104
            |.|.||:|     ..|.:          |:...:.|.:. .|..:.:|.||.|.....|..||..
Mosquito    24 ATPGEAIVGGIRSATPPIDDPVVFVRVGGRAARVEGLRN-RNTGLYSFRGIHYAESPTGQNRFAR 87

  Fly   105 AQPIGYQGRVNATVQSPNCAQFPELDRLRLSESRGENVDDCLTLDIYAPEGANQ---LPVLVFVH 166
            .|.....|.||||...|.|.| ||..    :..|....:|||.|:|:.|:..::   |||:|::|
Mosquito    88 PQYRHLSGDVNATSNGPPCPQ-PEPS----NPYRVIGHEDCLLLNIFTPQMPDETTGLPVVVWIH 147

  Fly   167 GEMLFDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVV 231
            |.....|.:.:...:.:....|:.|.|.|||..||.:...:.:|.||:||.|:..|:.|::..:.
Mosquito   148 GGGYRYGSASQYGAEPLTSNGVIFVPIQYRLGSFGMIGDGSRDLSGNLALLDMATAVRWVRDYIA 212

  Fly   232 HFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLA 296
            .|||:..|:.|||...|||.|..|:.:..|.:....::..||::|.|...:.:|:..........
Mosquito   213 WFGGDPAQIKLVGHGSGATAAMVLASATMARSSVTGVVAMSGSSLQPNAYEMEPVGAYREATMRH 277

  Fly   297 RCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQL---LLQNEHL--GLTQLGGFKLVVGDP-- 354
            ||       :|.....:..||....|.::|....:|   ..:.|.|  |:|...|...||.:.
Mosquito   278 RC-------AAGNETEVVKCLRDKTTEEIVQMDTELQAERFRGEKLVNGVTPQAGLNPVVEEKDD 335

  Fly   355 ----LGFLPSHP-ASLATNSSLALPMIIGATKDASAFIVSRIYDQLARLQSRNVSDYIDV-VLRH 413
                ||.|...| .||.......:|::||.|||.:|                   :.||| .::.
Mosquito   336 GRGLLGLLTDKPEVSLQAGDFPKIPLLIGVTKDETA-------------------NAIDVKEIQS 381

  Fly   414 TAPPSEHRLWKQWAL--REIFTPIQEQTASLQTVAPGLLELSNYI-------------------- 456
            |...:.:.|.|..:|  .|.|..:::|..:|.||. |:|:|..|:
Mosquito   382 TFKGATNFLKKTSSLVGLEGFLNVEKQVQALDTVG-GILQLDKYLEIPAGWDVTQIFSKLVEATT 445

  Fly   457 --LYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPF-------GVDASL---SDDSV 509
              ::..|.:.|.....::..|::|:|::|.:..:.......||.       |.|..|   .|:..
Mosquito   446 DAVFNLPAVVSAQAWSKTSKAFIYSFEHRSDSTKGRDFLAGLPIVAKTGTNGADGRLVGHGDELG 510

  Fly   510 YLFP----YPPEASRLNPL---------DRSLSRALVTMWVNFATTGVPNPSS----GVWPQATS 557
            .||.    |.      ||:         |.:..::..:....||..   |.||    .|:...:|
Mosquito   511 LLFDTHDVYG------NPIASATVKSAKDLNARKSFASFIAKFAYL---NTSSMHQDNVFKSFSS 566

  Fly   558 EYGPFLR 564
            :..||:|
Mosquito   567 KGTPFVR 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	148/592 (25%)
		Aes	<146..345	CDD:223730	57/206 (28%)
		RILP-like	<677..>717	CDD:304877
AgaP_AGAP013509	XP_003436330.1	Abhydrolase	42..549	CDD:304388	133/545 (24%)
AgaP_AGAP013509	XP_003436330.1	Aes	75..>280	CDD:223730	65/216 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910