Protein Alignment Glt and CES1

DIOPT Version :9

• Sequence 1: NP_001245946.1
• Gene: Glt / 34193
• FlyBaseID: FBgn0001114
• Length: 1026
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 163/589 - (27%)
• Similarity: 248/589 - (42%)
• Gaps: 116/589 - (19%)

  Fly    38 WLPEPLKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARF 102
            |...|..|           |....|....:|:.:.:.|..    :||..||||.:.....|..||
Human    17 WAGHPSSP-----------PVVDTVHGKVLGKFVSLEGFA----QPVAIFLGIPFAKPPLGPLRF 66

  Fly   103 QAAQPIGYQGRV-NATVQSPNCAQFPELDRLRLSE---SRGENV-----DDCLTLDIYAPEG--- 155
            ...||......| |||...|.|.|.|:..:| |||   :|.||:     :|||.|:||.|..
Human    67 TPPQPAEPWSFVKNATSYPPMCTQDPKAGQL-LSELFTNRKENIPLKLSEDCLYLNIYTPADLTK 130

  Fly   156 ANQLPVLVFVHGEMLFDGGSEEAQPDY-----VLEKDVLLVSINYRLAPFGFLSALTDELPGNVA 215
            .|:|||:|::||..|..|    |...|     ...::|::|:|.|||..:||.|...:...||..
Human   131 KNRLPVMVWIHGGGLMVG----AASTYDGLALAAHENVVVVTIQYRLGIWGFFSTGDEHSRGNWG 191

  Fly   216 LSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYL 280
            ..|...||.|:|.|:..||||.|.||:.|::.|......|.||..|.|||.:.|.:||.||...|
Human   192 HLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAISESGVALTSVL 256

  Fly   281 I---DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLT 342
            :   |.:||  ....|..|.|   ....||    .:..||.:....:|:    :..|:.:.|.|.
Human   257 VKKGDVKPL--AEQIAITAGC---KTTTSA----VMVHCLRQKTEEELL----ETTLKMKFLSLD 308

  Fly   343 QLGGFKLVVGDP------LGFLPSHPASLATNSSL-------ALPMIIGATKDASAFIVSRIYDQ 394
                   :.|||      ||.:......|.|...|       .:|.::|..|....:::.
Human   309 -------LQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP----- 361

  Fly   395 LARLQSRNVSD-YIDVVLRHTAPPSEHRLWKQWAL----REIFTPIQEQ-------TASLQTVAP 447
             .:|.|..:|: .:|   :.||   ...|||.:.|    :|:.....|:       |...:.:
Human   362 -MQLMSYPLSEGQLD---QKTA---MSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDL-- 417

  Fly   448 GLLELSNYILYRAPVINSISQSYR--SVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDD--S 508
             .|:|...:::..|.: .:::::|  ..|.|:|.|.||....     |:..|..|.....|:  |
Human   418 -FLDLIADVMFGVPSV-IVARNHRDAGAPTYMYEFQYRPSFS-----SDMKPKTVIGDHGDELFS 475

  Fly   509 VYLFPYPPEASRLNPLDRSLSRALVTMWVNFATTGVPNPSSGV--WPQATSEYGPFLRFTNNQQS 571
            |:..|:..|.:....:  .||:.::..|.|||..|.|| ..|:  ||:...:.| :|:...|.|:
Human   476 VFGAPFLKEGASEEEI--RLSKMVMKFWANFARNGNPN-GEGLPHWPEYNQKEG-YLQIGANTQA 536

  Fly   572 PLEL 575
            ..:|
Human   537 AQKL 540

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	160/572 (28%)
		Aes	<146..345	CDD:223730	69/209 (33%)
		RILP-like	<677..>717	CDD:304877
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	160/570 (28%)
		Aes	<122..>240	CDD:223730	44/121 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850