DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and Ces2

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	558	Identity:	155/558 - (27%)
Similarity:	237/558 - (42%)	Gaps:	98/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQS 120
            |:.:.::....||:.|...|.......|:.||||.:.....|..||...: |..:.|..:||.|.
  Rat    30 PESSPIRTTHTGQVQGKLDHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEPPEPWSGVRDATSQP 94

  Fly   121 PNCAQ-FPELDRLRLSE-----SRGENVDDCLTLDIYAP----EGANQLPVLVFVHGEML----- 170
            ..|.| ...||.:.|.:     |.....:|||.|::|||    ||:| |||:|::||..|
  Rat    95 AMCLQNLDILDEVGLLDMKMILSSISMSEDCLYLNVYAPAHAREGSN-LPVMVWIHGGALVVGMA 158

  Fly   171 --FDGGSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQLALEWLQRNVVHF 233
              :||..      ..:.:|:::|:|.|||...||.|...:...||....|...||.|:|:|:.||
  Rat   159 SMYDGSL------LTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHF 217

  Fly   234 GGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPLDTLSTFARLARC 298
            |||..:||:.|::.|.|...:..:|..:..||...|::||.||.|.||........:|.|:|:.|
  Rat   218 GGNPNRVTIFGESAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDLISETSETVSTTVAKLSGC 282

  Fly   299 PPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVVGDPLG-FLPSHP 362
                   .|...:.|..||.       ..:..::|:.|:        .||::.....| |||.||
  Rat   283 -------EAMDSEALVRCLR-------AKSGAEILVINK--------VFKMIPAVVDGEFLPRHP 325

  Fly   363 AS-LATNSSLALPMIIGATKDASAFIV------SRIYDQLARLQSRNVSDYIDVVLRHTA----- 415
            .. ||:.....:|.|||...|.....:      ::|..:|:|       :.:..||:.||
  Rat   326 KELLASEDFHPVPSIIGVNTDEYCCTIPMVMGTAQIIKELSR-------ENLQAVLKDTAAQMML 383

  Fly   416 PPSEHRLWKQWALREIFTPIQEQTASLQTVAPGLLELSNYILYRAPVINSISQSYRS-VPAYLYT 479
            ||....|        :.......|...||:.....|:....|:..|.: .::...|| .|.|.|.
  Rat   384 PPECGDL--------LMEEYMGNTDDSQTLQIQYTEMMGDFLFVIPAL-QVAHFQRSHAPVYFYE 439

  Fly   480 FDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPPEASRLN--PLDRSLSRALVTMWVNFATT 542
            |     .|...:..|..|..|.|..:|:..::|.......:|:  ..:|.|||.::..|.|||..
  Rat   440 F-----QHAPSYFKNVRPPHVKADHADEVPFVFGSFFSGMKLDFTEEERLLSRRMMKYWANFARQ 499

  Fly   543 GVPNPSSGV--WPQATSEYGPFLRFTNNQQSPLELDPH 578
            |.|| |.|:  ||.           .::.:..|:||.|
  Rat   500 GNPN-SEGLPYWPA-----------LDHDEQYLQLDTH 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	155/558 (28%)
		Aes	<146..345	CDD:223730	65/209 (31%)
		RILP-like	<677..>717	CDD:304877
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	154/557 (28%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	40/109 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930