DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Glt and nlgn4xb

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001159809.1	Gene:	nlgn4xb / 100147967	ZFINID:	ZDB-GENE-100309-1	Length:	795	Species:	Danio rerio

Alignment Length:	767	Identity:	192/767 - (25%)
Similarity:	295/767 - (38%)	Gaps:	205/767 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVN 115
            |.|.:.:...|..|  .:|||          ||..|||:.|.....|..||||.: |:.:.|..|
Zfish    27 TNYGKLRGLRVALP--SEILG----------PVEQFLGVPYAMAPTGERRFQAPEPPLSWPGIRN 79

  Fly   116 ATVQSPNCAQFPELDRLRLSESR----GENVD-----------DCLTLDIYAP------EGANQL 159
            ||..:|.|.||.| |||.|::..    ..|:|           |||.|:||.|      :.|...
Zfish    80 ATQFAPVCPQFLE-DRLLLTDMLPVWFTANLDTVATYVHDQSEDCLYLNIYVPTEEETQDDAGLK 143

  Fly   160 PVLVFVHGEMLFDG------GSEEAQPDYVLEK--DVLLVSINYRLAPFGFLSALTDELPGNVAL 216
            ||:|::||....:|      ||       ||..  :|::|::||||...||||.......||..|
Zfish   144 PVMVYIHGGSYVEGTGNMIDGS-------VLASYGNVIVVTVNYRLGVLGFLSTGDQAAKGNYGL 201

  Fly   217 SDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLI 281
            .|...||.|::.|:..|.|:..:||:.|...||:....|:||..:.:|||:.|:.|||||:.:.:
Zfish   202 LDQIQALRWVKENIQSFSGDPERVTIFGSGAGASCVSLLTLSHYSEDLFQKAIIHSGTALSSWAV 266

  Fly   282 DNQPLDTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGG 346
            :.||       |:..|.....:..:......|.:||..       ..:::|:.||.......:..
Zfish   267 NYQP-------AKYTRLLAEKVGCNEDDTLELIECLQS-------KNYKELIEQNITPAKYHIAF 317

  Fly   347 FKLVVGDPLGFLPSHPASLATNSS-LALPMIIGATKDASAFIVSRIYDQLARLQSRN----VSDY 406
            ..::.||   .:|..|..|..... |...:::|..:......|..|.|...|:.|.:    :|::
Zfish   318 GPVIDGD---VIPDDPQILMEQGEFLNYDIMLGVNQGEGYKFVDGILDSEDRVTSNDFEFAISEF 379

  Fly   407 IDVV---------LRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTASLQTVAPGLLE 451
            :|.:         ||.|.    ..::..||.||           :||       ..|.|||.:..
Zfish   380 VDHLYGYPEGKDTLRETI----KFMYTDWADRENPEMRRKTLVALFT-------DHQWVAPAVAT 433

  Fly   452 LSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGVDASLSDDSVYLFPYPP 516
            ...:..|.:             |.|.|.|    .||   ..|:..|...|:|..|:..|:|..|
Zfish   434 ADLHAQYGS-------------PTYFYAF----YHH---CQSDMKPAWADSSHGDELPYVFGIP- 477

  Fly   517 EASRLNPLDR----------SLSRALVTMWVNFATTGVPNPSSGVWPQAT--------------- 556
               .:.|.|.          .||..::|.|.|||.||.||...   ||.|
Zfish   478 ---MIGPTDLFNCNFSKNDIMLSAVVMTYWTNFAKTGDPNQPV---PQDTKFIHTKPNRFEEVAW 536

  Fly   557 SEYGP----FL------RFTNNQQSP-----LELDPHFGEGIYLPNYRVIYKPTTNFSPPITTTT 606
            |:|.|    :|      |..::.::.     |||.||    ::..|....|..:|...||..||.
Zfish   537 SKYNPKDQLYLHIGLKPRVRDHYRATKIAFWLELVPH----LHNINELFQYVSSTTKIPPQDTTP 597

  Fly   607 TTTTT-------TTTTSRPYAYNPYANWQNRPSQQHPNWHPADPEYVRAQEARQQ---------- 654
            .:.|.       .:||..|.|  |.||.:....||..:.|......:.|::...:
Zfish   598 FSYTKRLSNKLFPSTTRHPPA--PPANTKQMSDQQKTSEHADGTVIIEARDYSTELSVTIAVGAS 660

  Fly   655 ------------EFIREREQRRREQQLRDQQRYPQQEPREQQDERIRQQREQ 694
                        .:.:::.:....::|...:.:....||...:|.:..|.:|
Zfish   661 LLFLNILAFAALYYKKDKHRLESSRRLSPPRNHANDIPRVPSEELMSLQMKQ 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	164/618 (27%)
		Aes	<146..345	CDD:223730	63/212 (30%)
		RILP-like	<677..>717	CDD:304877	5/18 (28%)
nlgn4xb	NP_001159809.1	COesterase	17..567	CDD:278561	162/614 (26%)
nlgn4xb	NP_001159809.1	Aes	70..>243	CDD:223730	60/180 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840