DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Glt and nlgn2b

DIOPT Version :9

Sequence 1:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster
Sequence 2:	NP_001159808.1	Gene:	nlgn2b / 100002407	ZFINID:	ZDB-GENE-090918-3	Length:	860	Species:	Danio rerio

Alignment Length:	908	Identity:	206/908 - (22%)
Similarity:	328/908 - (36%)	Gaps:	286/908 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GQILGISGHKTIANR---PVNAFLGIRYGTVGGGLARFQAAQ-PIGYQGRVNATVQSPNCAQ--- 125
            |::.|:  .|.:.|.   ||..:||:.|.|...|..|||..: |..:|...|||..:|.|.|
Zfish    59 GKLRGV--RKELNNEILGPVEQYLGVPYATPPVGERRFQPPEAPGSWQEIRNATQFAPVCPQNIH 121

  Fly   126 --FPEL-------DRLRLSESRGEN-VDDCLTLDIYAPEGANQL--------------------- 159
              .||:       |.|..:.:..:| .:|||.|::|.|.....|
Zfish   122 GVLPEIMLPVWFTDNLDAAAAYVQNQSEDCLYLNVYVPTEDGPLTKKHDESSMNRPRDEDIRDRR 186

  Fly   160 --PVLVFVHGEMLFDG-GSEEAQPDYVLEKDVLLVSINYRLAPFGFLSALTDELPGNVALSDLQL 221
              ||::|:||....:| |:...........:|::|::||||...||||:......||..|.|...
Zfish   187 KKPVMLFIHGGSFMEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGFLSSGDQSAKGNYGLLDQIQ 251

  Fly   222 ALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQSGTALNPYLIDNQPL 286
            ||.||..|:.||||:..::|:.|...||:..:.|.||..:..|||:.|.|||:|::.:.::.:||
Zfish   252 ALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQRAIAQSGSAISSWSVNYRPL 316

  Fly   287 DTLSTFARLARCPPPSINPSAQGLKPLYDCLARLPTSQLVAAFEQLLLQNEHLGLTQLGGFKLVV 351
            ......|:...|   |.:.:|.    |.|||.|       .::.:|:.|:.......:....:|.
Zfish   317 MYTKILAKKVGC---SYSDTAD----LVDCLRR-------KSYRELVDQDVQPARYHIAFGPVVD 367

  Fly   352 GDPLGFLPSHPASLATNSS-LALPMIIGATK----------DASAFIVSRIYDQLARLQSRNVSD 405
            ||   .:|..|..|..... |...:::|..:          :....|.:..:|.       .:|:
Zfish   368 GD---VVPDDPEILMQQGEFLNYDILLGVNQGEGLKFVDDNEGEEGISAASFDY-------TISN 422

  Fly   406 YID---------VVLRHTAPPSEHRLWKQWALRE-----------IFTPIQEQTASLQTVAPGLL 450
            ::|         .:||.|.    ..::..||.|:           :||       ..|.|||.:.
Zfish   423 FVDNLYGYPEGKDILRETI----KFMYTDWADRDNGDMRRKTLLALFT-------DHQWVAPAVA 476

  Fly   451 ELSNYILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHL-SNPLPFGVDASLSDDSVYLFPY 514
            ....:..:::||             |.|||     ||   |. :...|...||:..|:..|:|..
Zfish   477 TAKLHAEFQSPV-------------YFYTF-----HH---HCQTEARPEWADAAHGDEIPYVFGV 520

  Fly   515 P-PEASRLNPL-----DRSLSRALVTMWVNFATTGVPN-------------PS---SGVWPQATS 557
            | ..|:.|.|.     |..||..::|.|.|||.||.||             |:   ..:|.:.:|
Zfish   521 PMVGATELFPCNFSKNDIMLSAVVMTYWTNFAKTGDPNIPVPQDTKFIHTKPNRFEEVIWTKFSS 585

  Fly   558 EYGPFL------RFTNNQQSP-----LELDPHFGEGIY--LPNYRVIYKPTTNFSPPITTTTTTT 609
            :...:|      |..:|.::.     |||.||. ..|:  :|.|.....|.....|....|..:.
Zfish   586 KDKQYLHIGLKPRIRDNYRANKVAFWLELVPHL-HTIHDEIPTYTTQLPPGAPHRPGWKGTAQSP 649

  Fly   610 TTTTTTSRPYAYNPYANWQNRPSQQHP--NWHPADPEYVRAQEARQQEFIREREQRRREQQLRDQ 672
            .|.:|                   :||  :.:|.||:.                    |......
Zfish   650 GTRST-------------------RHPTVSTYPPDPDL--------------------EGSEHPP 675

  Fly   673 QRYP-QQEPREQQDE--------------------RIRQQREQEERLRQQREQEERLRQQR---- 712
            :|:| ....|:...|                    .:..:|::...|.|:|.:  ||..||
Zfish   676 ERFPFPSNTRDYSTELSVTVAVGASLLFLNVLAFAALYYKRDKRHELLQRRHR--RLSPQRGAVP 738

  Fly   713 ---------ELEERIRQQQEREQYEREQQEREQREREELERQQREREQQQPEQQPEYNPEPVNPW 768
                     ..:..:.|::|....:.:||           |.:.:.....|.:....:.||:.|
Zfish   739 GVGIVGGPPHNDLALSQEEELMSLQMKQQ-----------RVELDHGTPLPTRGLHGDLEPLRP- 791

  Fly   769 GYPVQEPQ--------PDDNP-------------EDGRLPYPSYEQYGP-------EGNENLP 803
              ||..|.        |:|.|             ..|..|..::..|.|       ..|..||
Zfish   792 --PVCPPDYTLALRRAPEDVPLMTANTLSMIPSTITGMQPLHAFNTYPPAPAPSAGHSNNALP 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	157/616 (25%)
		Aes	<146..345	CDD:223730	63/222 (28%)
		RILP-like	<677..>717	CDD:304877	10/72 (14%)
nlgn2b	NP_001159808.1	COesterase	47..611	CDD:278561	153/609 (25%)
nlgn2b	NP_001159808.1	Aes	<181..>279	CDD:223730	32/97 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840