DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and SEMA3E

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_036563.1	Gene:	SEMA3E / 9723	HGNCID:	10727	Length:	775	Species:	Homo sapiens

Alignment Length:	759	Identity:	209/759 - (27%)
Similarity:	335/759 - (44%)	Gaps:	139/759 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 HFKLVTKDGNSLLIGARNTVFNLSIHDLVE-QQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMV 159
            |..|:.:....|.:|.|:.|::||:..:.: .:.:.|.|.....:.|::||||...|.||:|::.
Human    59 HTMLLDEYQERLFVGGRDLVYSLSLERISDGYKEIHWPSTALKMEECIMKGKDAGECANYVRVLH 123

  Fly   160 VPSPGRLFVCGTNSFRPMCN----TYIISDSNYTLEA--TKNGQAVCPYDPRHNSTSVLADNELY 218
            ..:...|..|||.:|.|:|.    .|.:.|..:.||:  ::.|:..||:||..:..|.|..:||:
Human   124 HYNRTHLLTCGTGAFDPVCAFIRVGYHLEDPLFHLESPRSERGRGRCPFDPSSSFISTLIGSELF 188

  Fly   219 SGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGD-------FVYFFFRETAV 271
            :|..:|:...|..|:|.     .::||..|...|..|.||.|:...|       .|||||.|.|:
Human   189 AGLYSDYWSRDAAIFRSMGRLAHIRTEHDDERLLKEPKFVGSYMIPDNEDRDDNKVYFFFTEKAL 253

  Fly   272 EFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEG 334
            |..|...|||:||.|:|..|.||.....|:|::|||:||.||:||  ....||:|::....|...
Human   254 EAENNAHAIYTRVGRLCVNDVGGQRILVNKWSTFLKARLVCSVPGMNGIDTYFDELEDVFLLPTR 318

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
            .:   .:.:|:|:|||.||...|.|:|.:.:..|...|.|.:..:.|...:| .|...|||.|||
Human   319 DH---KNPVIFGLFNTTSNIFRGHAICVYHMSSIRAAFNGPYAHKEGPEYHW-SVYEGKVPYPRP 379

  Fly   400 GSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |||        :..::..||..:.|.::|.||.:.:.....:||||:|...|...||||| :::.
Human   380 GSCASKVNGGRYGTTKDYPDDAIRFARSHPLMYQAIKPAHKKPILVKTDGKYNLKQIAVD-RVEA 443

  Fly   457 PGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPK 521
            ..|: |||:|:|||:|.::|.:...:.: .:.:..|::||:.:.....||.::||....|
Human   444 EDGQ-YDVLFIGTDNGIVLKVITIYNQE-MESMEEVILEELQIFKDPVPIISMEISSKRQ----- 501

  Fly   522 DGSYDDGKLIIVTDSQVVAIQLHRCHNDKI-TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEE 585
                   :|.|.:.|.|..::.|.|  |.. ::|::|...:|||||||.|:  |          .
Human   502 -------QLYIGSASAVAQVRFHHC--DMYGSACADCCLARDPYCAWDGIS--C----------S 545

  Fly   586 NYFYQNVATGQHAACPSGKINSKDANAGEQ-------------------KGFRNDMDLLDSRRQS 631
            .|:    .||.||.....:.:.:..||.:|                   .|..|:..||:...:|
Human   546 RYY----PTGTHAKRRFRRQDVRHGNAAQQCFGQQFVGDALDKTEEHLAYGIENNSTLLECTPRS 606

  Fly   632 KDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCHK---- 691
            ...::|..:.|..|..:       .:...:..|:.:..|.:|..|.....| |||....|.
Human   607 LQAKVIWFVQKGRETRK-------EEVKTDDRVVKMDLGLLFLRLHKSDAGTYFCQTVEHSFVHT 664

  Fly   692 ---------------------DEDD---NLPYPDTE---------YEYFEQRQNVNSFPSS---- 719
                                 ||:|   .:|.|...         |:.|.|....::|...
Human   665 VRKITLEVVEEEKVEDMFNKDDEEDRHHRMPCPAQSSISQGAKPWYKEFLQLIGYSNFQRVEEYC 729

  Fly   720 ----CRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTL 759
                |..::..||.....:..||.|........|.....|::||
Human   730 EKVWCTDRKRKKLKMSPSKWKYANPQEKKLRSKPEHYRLPRHTL 773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	152/478 (32%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/34 (38%)
SEMA3E	NP_036563.1	Sema_3E	49..519	CDD:200514	152/478 (32%)
		PSI	518..566	CDD:214655	18/65 (28%)
		Ig_Semaphorin_classIII	585..670	CDD:143279	17/91 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..775		8/32 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.010