DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1a and PLXNA4

DIOPT Version :9

Sequence 1:NP_001260265.1 Gene:Sema1a / 34192 FlyBaseID:FBgn0011259 Length:1131 Species:Drosophila melanogaster
Sequence 2:NP_001380826.1 Gene:PLXNA4 / 91584 HGNCID:9102 Length:1894 Species:Homo sapiens


Alignment Length:883 Identity:172/883 - (19%)
Similarity:313/883 - (35%) Gaps:252/883 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRP-------KLYVELGPEDVLKFVGNESVVDHFKLVTKDGNS 106
            |....||..:|::|..|:.....:|       :.:|....|....|  |..|||.     :.|: 
Human     6 WNWTCLLSHLLMVGMGSSTLLTRQPAPLSQKQRSFVTFRGEPAEGF--NHLVVDE-----RTGH- 62

  Fly   107 LLIGARNTVFNLS--IHDLVEQQRLVWTSPEDDTKMC----LVKGKDE--EACQNYIRIMVVP-S 162
            :.:||.|.::.||  :..||..:    |.|::|...|    :|:..:|  ....|..:::::. .
Human    63 IYLGAVNRIYKLSSDLKVLVTHE----TGPDEDNPKCYPPRIVQTCNEPLTTTNNVNKMLLIDYK 123

  Fly   163 PGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSG 227
            ..||..|| :.::.:|....:.|      ..|.|:   ||..:.:..|.:.::....|.:..:|.
Human   124 ENRLIACG-SLYQGICKLLRLED------LFKLGE---PYHKKEHYLSGVNESGSVFGVIVSYSN 178

  Fly   228 SDPIIY-----------------REPLQTEQYDSL------------SLNAPN------------ 251
            .|..::                 |:..:..:.|.:            .:..|:            
Human   179 LDDKLFIATAVDGKPEYFPTISSRKLTKNSEADGMFAYVFHDEFVASMIKIPSDTFTIIPDFDIY 243

  Fly   252 FVSSFTQGDFVYFFFRETAVEFIN-----CGKAIY-SRVARVCKWDKGGPHRFRNRWTSFLKSRL 310
            :|..|:.|:||||...:.  |.::     ..:.:| |::.|:||.|        ..:.|:::..:
Human   244 YVYGFSSGNFVYFLTLQP--EMVSPPGSTTKEQVYTSKLVRLCKED--------TAFNSYVEVPI 298

  Fly   311 NCSIPG-DYPFYFNEIQSASNLVEGQYGSM--SSKLIYGVFN----TPSNSIPGSAVCAFALQDI 368
            .|...| :|........|.:..|.|:...:  ...|::.||:    ....|:..||:|.|.|:.|
Human   299 GCERSGVEYRLLQAAYLSKAGAVLGRTLGVHPDDDLLFTVFSKGQKRKMKSLDESALCIFILKQI 363

  Fly   369 ADTFEGQ----FKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLMDENVPA 429
            .|..:.:    ::.:..::..||.|.:  :|      |.:....:.|   ||..    :|.|.|.
Human   364 NDRIKERLQSCYRGEGTLDLAWLKVKD--IP------CSSALLTIDD---NFCG----LDMNAPL 413

  Fly   430 FFSQPILVRTSTIY---RFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIK-SVNAESADSADKVT 490
            ..|.  :||...::   |....:|.|.:.    |.:.:.||||..||:.| .|:....::....|
Human   414 GVSD--MVRGIPVFTEDRDRMTSVIAYVY----KNHSLAFVGTKSGKLKKIRVDGPRGNALQYET 472

  Fly   491 SVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCS 555
            ..|::...||            |.|.:      |.|..:|.|:::.|:..:.:..|  .:..||.
Human   473 VQVVDPGPVL------------RDMAF------SKDHEQLYIMSERQLTRVPVESC--GQYQSCG 517

  Fly   556 ECVALQDPYCAWDKIAGKC-------RSHGAPRWLEE-------NYFYQNVATGQHAA------- 599
            ||:...||:|.|..:...|       ||....|:..|       .....|::..|:..       
Human   518 ECLGSGDPHCGWCVLHNTCTRKERCERSKEPRRFASEMKQCVRLTVHPNNISVSQYNVLLVLETY 582

  Fly   600 -CP--SGKINSKDANAGEQKGF--RNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYT 659
             .|  |..:|....:..|..|.  .|.:.......:...:.|.:|.|.:         ::..|..
Human   583 NVPELSAGVNCTFEDLSEMDGLVVGNQIQCYSPAAKEVPRIITENGDHH---------VVQLQLK 638

  Fly   660 VETLVMAVLAGSIFSLLVGFFTGYFCG------------RRCHKDEDDNLPYPDTEYEYFEQRQN 712
            .:...|...:.|        |..|.|.            .|||               :.:.|..
Human   639 SKETGMTFASTS--------FVFYNCSVHNSCLSCVESPYRCH---------------WCKYRHV 680

  Fly   713 VNSFPSSCRIQQEPKLLPQ-------VEEVTYAEPVL---------LPQPPPPNK-----MHSPK 756
            ....|.:|..|:....||:       |:::.....|:         ||||....:     ::...
Human   681 CTHDPKTCSFQEGRVKLPEDCPQLLRVDKILVPVEVIKPITLKAKNLPQPQSGQRGYECILNIQG 745

  Fly   757 NTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRD 794
            :..|.|.:..     ||.:: |.|    ||..||.|.:
Human   746 SEQRVPALRF-----NSSSV-QCQ----NTSYSYEGME 773

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1aNP_001260265.1 Sema_1A 91..546 CDD:200498 104/525 (20%)
PSI 545..>579 CDD:214655 12/40 (30%)
PLXNA4NP_001380826.1 Sema_plexin_A4 39..511 CDD:200535 109/544 (20%)
PSI 510..548 CDD:214655 12/39 (31%)
TIG_plexin 564..654 CDD:407808 15/106 (14%)
PSI 655..702 CDD:396154 10/61 (16%)
TIG_2 708..802 CDD:407859 16/76 (21%)
PSI 804..856 CDD:396154
IPT_plexin_repeat1 858..953 CDD:238585
IPT_plexin_repeat2 955..1038 CDD:238584
IPT_plexin_repeat3 1040..1140 CDD:238586
IPT_PCSR 1142..1222 CDD:238337
Plexin_cytopl 1311..1864 CDD:400574
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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