Protein Alignment Sema1a and SEMA5A

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_003957.2
• Gene: SEMA5A / 9037
• HGNCID: 10736
• Length: 1074
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 219/557 - (39%)
• Similarity: 290/557 - (52%)
• Gaps: 92/557 - (16%)

  Fly    76 YVELGPEDVLKFVGNESVVDHFKLVTKDG-NSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTK 139
            |.|:||  .|:....::.||..:|....| ..|::||||.:|.|.:.||...|.:.|...|...|
Human    40 YKEIGP--WLREFRAKNAVDFSQLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVEWECDEATKK 102

  Fly   140 MCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYT-LEATKNGQAVCPYD 203
            .|..|||.:|.||||||:::| ...|||.||||:|.|:|...  |.||.| :....:|.|.|||.
Human   103 ACYSKGKSKEECQNYIRVLLV-GGDRLFTCGTNAFTPVCTNR--SLSNLTEIHDQISGMARCPYS 164

  Fly   204 PRHNSTSVL-ADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFV 262
            |:||||::| |..|||:.|..||.|.||.|||.     ||:|.||:|..||.||||||:..|:|.
Human   165 PQHNSTALLTAGGELYAATAMDFPGRDPAIYRSLGILPPLRTAQYNSKWLNEPNFVSSYDIGNFT 229

  Fly   263 YFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQS 327
            ||||||.|||. :|||.::||.|||||.|.||.....:.||:|:|:|||||.||:.|||:||:||
Human   230 YFFFRENAVEH-DCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQS 293

  Fly   328 ASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNA 392
            ...|.|       ..||||:|.|..|||..||||.|.|..||..|.|.||.|....|.|||
Human   294 TFFLPE-------LDLIYGIFTTNVNSIAASAVCVFNLSAIAQAFSGPFKYQENSRSAWLP---- 347

  Fly   393 KVPDPRPG-SC---------HNDSRALPDPTLNFIKTHSLMD--ENVPAFFSQPILVRTSTIYRF 445
             .|:|.|. .|         :...|.|.| ...||..|.::.  ..||:|....        .||
Human   348 -YPNPNPHFQCGTVDQGLYVNLTERNLQD-AQKFILMHEVVQPVTTVPSFMEDN--------SRF 402

  Fly   446 TQIAVDAQIKTPGGKT-YDVIFVGTDHGKIIK---SVNAESADSADKVTSVVIEEIDVL--TKSE 504
            :.:|||.   ..|.:. ..:|::.||:|.|.|   .:|..|       :|.::|||::.  .:.|
Human   403 SHVAVDV---VQGREALVHIIYLATDYGTIKKVRVPLNQTS-------SSCLLEEIELFPERRRE 457

  Fly   505 PIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDK 569
            |||:|:|:            :....|.:.....||.|.|.||...:  :.|.|:..|||||.||.
Human   458 PIRSLQIL------------HSQSVLFVGLREHVVKIPLKRCQFYR--TRSTCIGAQDPYCGWDV 508

  Fly   570 IAGKCRSHGAPRWLEEN----YFYQNVATGQHAACPS 602
            :..||.|      |||:    .:.|::     :|||:
Human   509 VMKKCTS------LEESLSMTQWEQSI-----SACPT 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	193/480 (40%)
		PSI	545..>579	CDD:214655	14/33 (42%)
SEMA5A	NP_003957.2	Sema_5A	50..485	CDD:200524	192/481 (40%)
		PSI	486..533	CDD:279745	19/59 (32%)
		TSP1	544..595	CDD:214559
		TSP1	598..651	CDD:214559
		TSP1	656..702	CDD:214559
		TSP1	787..839	CDD:214559
		TSP1	844..896	CDD:214559
		TSP1	899..940	CDD:214559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810