DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1a and SEMA7A

DIOPT Version :9

Sequence 1:NP_001260265.1 Gene:Sema1a / 34192 FlyBaseID:FBgn0011259 Length:1131 Species:Drosophila melanogaster
Sequence 2:NP_003603.1 Gene:SEMA7A / 8482 HGNCID:10741 Length:666 Species:Homo sapiens


Alignment Length:708 Identity:174/708 - (24%)
Similarity:294/708 - (41%) Gaps:151/708 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LLLTVLVIGNQSAWQENIR--PKLYV----ELGPEDVLKFVGNESVVDHFKLVTKDG-NSLLIGA 111
            |.|.:|:....::.|.::|  |:::.    .:| :|.:.|...|   .|..|..:.| :|:.:|.
Human    31 LRLLLLLWAAAASAQGHLRSGPRIFAVWKGHVG-QDRVDFGQTE---PHTVLFHEPGSSSVWVGG 91

  Fly   112 RNTVFNLSIHDLVE-QQRLVWTSPEDDTK-MCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSF 174
            |..|:   :.|..| :...|.|.....|| .||    |:..|:|||.::...|.| |..||||:.
Human    92 RGKVY---LFDFPEGKNASVRTVNIGSTKGSCL----DKRDCENYITLLERRSEG-LLACGTNAR 148

  Fly   175 RPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTV--ADFSGSDPIIYREPL 237
            .|.|...:    |.|:......:...|:.|..||..:...:|:|| |:  .:::|..|...|...
Human   149 HPSCWNLV----NGTVVPLGEMRGYAPFSPDENSLVLFEGDEVYS-TIRKQEYNGKIPRFRRIRG 208

  Fly   238 QTEQY--DSLSLNAPNFVSSF------TQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGG 294
            ::|.|  |::..| |.|:.:.      ...|.:|:||||...:.........||||::|:.|:||
Human   209 ESELYTSDTVMQN-PQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGG 272

  Fly   295 PHRFR-NRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGS 358
            ..... ::|.:|||:.|.||...... .||.:|... |:....|......:||||:.|.|.   |
Human   273 ESSLSVSKWNTFLKAMLVCSDAATNK-NFNRLQDVF-LLPDPSGQWRDTRVYGVFSNPWNY---S 332

  Fly   359 AVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLM 423
            |||.::|.||...|          .::.|...::.:|:||||.|..|.:.:|..|......|..:
Human   333 AVCVYSLGDIDKVF----------RTSSLKGYHSSLPNPRPGKCLPDQQPIPTETFQVADRHPEV 387

  Fly   424 DENV--------PAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNA 480
            .:.|        |.|.|:         |.:.::||. :::...|:|:.|:::.||.|.|.|.|  
Human   388 AQRVEPMGPLKTPLFHSK---------YHYQKVAVH-RMQASHGETFHVLYLTTDRGTIHKVV-- 440

  Fly   481 ESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHR 545
               :..::..|.....:::    :|.|....::||..|..:      .||.:.:..:|..:.|..
Human   441 ---EPGEQEHSFAFNIMEI----QPFRRAAAIQTMSLDAER------RKLYVSSQWEVSQVPLDL 492

  Fly   546 CHNDKI--TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ-HAACPSGKINS 607
            |   ::  ..|..|:..:||||.||:  |:|.|    .:..|....|::...: |..||    |.
Human   493 C---EVYGGGCHGCLMSRDPYCGWDQ--GRCIS----IYSSERSVLQSINPAEPHKECP----NP 544

  Fly   608 KDANAGEQKGFRNDMDL-----------LDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVE 661
            |...|..||     :.|           ::||..:......:|::::.|....|.:.|       
Human   545 KPDKAPLQK-----VSLAPNSRYYLSCPMESRHATYSWRHKENVEQSCEPGHQSPNCI------- 597

  Fly   662 TLVMAVLAGSIF--SLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFP 717
                      :|  :|....:..|||..:              |..||.:.|:....|
Human   598 ----------LFIENLTAQQYGHYFCEAQ--------------EGSYFREAQHWQLLP 631

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1aNP_001260265.1 Sema_1A 91..546 CDD:200498 126/476 (26%)
PSI 545..>579 CDD:214655 12/35 (34%)
SEMA7ANP_003603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Sema_7A 72..491 CDD:200504 125/475 (26%)
Cell attachment site. /evidence=ECO:0000255 267..269 0/1 (0%)
Interaction with integrins 267..269 0/1 (0%)
PSI 493..>527 CDD:307546 13/42 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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