DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and Sema6b

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_006244410.1	Gene:	Sema6b / 84609	RGDID:	69278	Length:	957	Species:	Rattus norvegicus

Alignment Length:	1084	Identity:	293/1084 - (27%)
Similarity:	439/1084 - (40%)	Gaps:	312/1084 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLK----FVGN--------ESVVD-HFKLVTKD 103
            :||||.:|.: ....:.:...|   :.:.|.|.|.    |||:        |...| :.:.|.:.
  Rat    84 LFLLLLLLRV-THGLFPDEPPP---LSVAPRDYLSHYPVFVGSGPGRLTPAEGAEDLNIQRVLRV 144

  Fly   104 GNSLLIGARNTVFNLSIH-----DLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSP 163
            ..:|.||.|:.::.:.:.     :|..|::|.|.|...|..:|.:|||.|..|:|:::::::...
  Rat   145 NRTLFIGDRDNLYQVELEPSTSTELRYQRKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRDE 209

  Fly   164 GRLFVCGTNSFRPMCNTYIISDSNYTLEATK------NGQAVCPYDPRHNSTSVLADNELYSGTV 222
            ..|||||:|:|.|:|       :||:::..:      :|.|.|||||:|.:.::.:|..|::.||
  Rat   210 STLFVCGSNAFNPIC-------ANYSMDTLQLLGDNISGMARCPYDPKHANVALFSDGMLFTATV 267

  Fly   223 ADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYS 282
            .||...|.:|||.     .|:|.::||.....|.||.:...|..|||||||.|:||....|.:.|
  Rat   268 TDFLAIDAVIYRSLGDRPTLRTVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVS 332

  Fly   283 RVARVCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSK-LIY 345
            |||||||.|.|| |.....:||||||:|||||:|||..||||.:|:.:.:|     |:..: :|.
  Rat   333 RVARVCKNDVGGSPRVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVV-----SLGGRPVIL 392

  Fly   346 GVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC------HN 404
            .||:||||||||||||||.:..:|..|||:|:||....|.|.||...:||.||||.|      :|
  Rat   393 AVFSTPSNSIPGSAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYN 457

  Fly   405 DSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGT 469
            .|.||||..|||:|||.||||.||:....|.:|||...::.|::|||......|.:|  ::|:|:
  Rat   458 ASNALPDEILNFVKTHPLMDEAVPSLGHSPWIVRTLIRHQLTRVAVDVGAGPWGNQT--IVFLGS 520

  Fly   470 DHGKIIK-SVNAESADSADKVTSVVIEEIDVLTKSEPIRNL------EIVRTMQYDQPKDGSYDD 527
            :.|.::| .|...::.|.....|:.:||.:........|:.      :.:.:::.|....|
  Rat   521 EVGTVLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCGRSSSAGEWGQRLLSLELDAASGG---- 581

  Fly   528 GKLIIVTDSQVVAIQLHRCHNDKITSC-SECVALQDPYCAWDKIAGKC--RSHGAPRWLEENYFY 589
              |:......||.:.:.||  ...:.| ..|:..|||||.|.. .|.|  ...|.....|:
  Rat   582 --LLAAFPRCVVRVPVARC--QLYSGCMKNCIGSQDPYCGWAP-DGSCIFLRPGTSATFEQ---- 637

  Fly   590 QNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADII 654
                               |.:.....|..:...||  |....|..               |.::
  Rat   638 -------------------DVSGASTSGLGDCTGLL--RASLSDDR---------------AGLV 666

  Fly   655 NAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR------CHKDEDDNLPYPDTEYEYFEQRQNV 713
            :....|.:.|.|.:.|::.|   ||..|:|.|.|      ..||::..|.:..:|
  Rat   667 SVNLLVTSSVAAFVVGAVVS---GFSVGWFVGLRERRELARRKDKEAILAHGGSE---------- 718

  Fly   714 NSFPSSCRIQQ--------------------EPKLLPQVEE------VTYAEP-----VLLPQP- 746
             :..|..|:.:                    |..|.|.::.      :.:..|     .|||.|
  Rat   719 -AVLSVSRLGERRGTGTGGRGGAGGGPGGPPEALLAPLMQNGWTKAALLHGGPHDLDSGLLPTPE 782

  Fly   747 --PPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNY 809
              |.|.|        |.|..|     |::..|   .|..::              .||.::
  Rat   783 QTPLPQK--------RLPTTH-----PHAHAL---GPRAWD--------------HSHALL---- 813

  Fly   810 RRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQ--QPHSSSGS 872
                         .|..:|:....:..||..|||           .|.:...:|:  .|.|...|
  Rat   814 -------------SASASTSLLLLAHTRAPEQPP-----------VPTESGPESRLCAPRSCRAS 854

  Fly   873 SPVMSNSSSSPAPPSSSP------SPQESPKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQSH 931
            .|     ...|..|.:||      |....|.:.|.:..|
  Rat   855 HP-----GDFPLTPHASPDRRRVVSAPTGPLDSSSVGDDL------------------------- 889

  Fly   932 PHPLPPPGPTTPPAQPRARSPMIGRTYAKSMPVTPVQPQSPLAETPSYELYERHSDAATFHFGDE 996
                  |||.:|||....|.|               .|..|    |:..|...|    ||:.|:.
  Rat   890 ------PGPWSPPATSSLRRP---------------GPHGP----PTAALRRTH----TFNSGEA 925

  Fly   997 DDDDDDEHDHEDTSSLAMITPPPPYDTPHLI-------ASPPLP 1033
            .........|            .|.|:.||:       .:||:|
  Rat   926 RPGGHRPRRH------------APADSTHLLPCGTGERTAPPVP 957

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	179/486 (37%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/36 (33%)
Sema6b	XP_006244410.1	Sema_6B	128..596	CDD:200528	179/487 (37%)
Sema6b	XP_006244410.1	PSI	597..>626	CDD:279745	12/31 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	319	1.000	Domainoid score	I1206
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2014
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8939
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.860