DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1a and SEMA6D

DIOPT Version :9

Sequence 1:NP_001260265.1 Gene:Sema1a / 34192 FlyBaseID:FBgn0011259 Length:1131 Species:Drosophila melanogaster
Sequence 2:NP_001345281.1 Gene:SEMA6D / 80031 HGNCID:16770 Length:1086 Species:Homo sapiens


Alignment Length:1111 Identity:312/1111 - (28%)
Similarity:479/1111 - (43%) Gaps:233/1111 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 GNESVVDH---FKLVTKDGNSLLIGARNTVFNLSIHDL-----VEQQRLVWTSPEDDTKMCLVKG 145
            ||||  .|   |:|:.|..::|.|..|:.|:.::::::     :..::|.|.|.:.|.:.|.:||
Human    50 GNES--QHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKG 112

  Fly   146 KDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTS 210
            |.::.|.|:|::.|..:...:||||||:|.|||..|.:|...|..|.. :|.|.||:|.|..:.:
Human   113 KHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEI-SGLARCPFDARQTNVA 176

  Fly   211 VLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETA 270
            :.||.:|||.|||||..||.:|||     ..|:|.:|||..:..|:|:.:...|::|||||||.|
Human   177 LFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIA 241

  Fly   271 VEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG 334
            ||..|.|||:||||||:||.|.||..| ....||||||:|||||:|||..|||:.:||.::::  
Human   242 VEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDII-- 304

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
            |...:.:  :.|||.|..|||||||||||::.||...|:|:||||...:|.|..|...|||.|||
Human   305 QINGIPT--VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRP 367

  Fly   400 GSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKT 456
            |.|        :..|...||.||:|||:|.|||..||....:|...:|...||.|.|:||   .:
Human   368 GCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVD---HS 429

  Fly   457 PGG-KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLT----KSEPIRNLEIVRTMQ 516
            .|. :.|.|||||::.|.::|.:...|..|.:  .||::|||:...    .:|...:.::: ::|
Human   430 AGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLN--DSVLLEEIEAYNHAKCSAENEEDKKVI-SLQ 491

  Fly   517 YDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCAWDKIAGKC------ 574
            .|:      |...|.:...|.::.|.|.||  ::..||.: |:|.:||||.| ...|.|      
Human   492 LDK------DHHALYVAFSSCIIRIPLSRC--ERYGSCKKSCIASRDPYCGW-LSQGSCGRVTPG 547

  Fly   575 -----------RSHGAPRWLEENYFYQNVATGQ-HAACPSGKINSKDANAGEQK---GFRNDMDL 624
                       .:|.|..:.::..|......|. |...|:       :...:.|   |..:||::
Human   548 MLLLTEDFFAFHNHSAEGYEQDTEFGNTAHLGDCHEILPT-------STTPDYKIFGGPTSDMEV 605

  Fly   625 LDSR--------------------RQSKDQEIIDNIDKN---FEGP----------QISADIINA 656
            ..|.                    :.:..::.:...|.|   |..|          ::.:...|.
Human   606 SSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQ 670

  Fly   657 QYTVETLVMAVLAGSIFSLLVGFFTG--YFC--------GRRCHKDEDDNLPYPDTEYEYF---- 707
            ...:..|:..|.|..:   |..|..|  .:|        .|:.|||.:......|:...:.    
Human   671 MVHMNVLITCVFAAFV---LGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNG 732

  Fly   708 -------EQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMH 765
                   |.:||::|......:....|.||...:..........|||....:.:|::|   |.:|
Human   733 LFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPEST---PVLH 794

  Fly   766 QM--------------HQGPNSETLFQFQPDG------------------------YNTQQSYRG 792
            |.              |.....||. ||.|..                        |||..|   
Human   795 QKTLQAMKSHSEKAHGHGASRKETP-QFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFS--- 855

  Fly   793 RDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQ 857
              |....::.:.:.:........|:.|..:::|::.||.|..|        :|  :....|| |:
Human   856 --NSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLL--------KH--LNDPNSN-PK 907

  Fly   858 QQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPS----PQESPKNCSYIYRDXLICNTKSMPL-- 916
            ......|..|.:....|:.|.|...|..|:...|    |...|:|......|  :..|..:|:  
Human   908 AIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVD--VPTTPGVPMTS 970

  Fly   917 IQAQSTHAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGR------------TYAKSMPVTPVQP 969
            ::.|..:.:...|.|.....|....:|.....:|.|.:.|            .|.:..||: |..
Human   971 LERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVS-VHL 1034

  Fly   970 QSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPHLIASPPLPP 1034
            |..|:...||.     |:......|           .:.|.||....||.|...|.   :|.:.|
Human  1035 QPSLSRQSSYT-----SNGTLPRTG-----------LKRTPSLKPDVPPKPSFVPQ---TPSVRP 1080

  Fly  1035 PRRFRF 1040
            ..::.:
Human  1081 LNKYTY 1086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1aNP_001260265.1 Sema_1A 91..546 CDD:200498 191/481 (40%)
PSI 545..>579 CDD:214655 14/51 (27%)
SEMA6DNP_001345281.1 Sema_6D 49..513 CDD:200530 192/481 (40%)
PSI 514..>543 CDD:307546 13/31 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..788 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..838 6/38 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 852..887 5/39 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1018 19/92 (21%)
Herpes_BLLF1 944..>1080 CDD:330317 32/157 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1086 15/70 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 318 1.000 Domainoid score I1252
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 373 1.000 Inparanoid score I2116
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000892
OrthoInspector 1 1.000 - - mtm8465
orthoMCL 1 0.900 - - OOG6_101616
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4157
SonicParanoid 1 1.000 - - X415
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.850

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