DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and LOC798168

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_009290884.1	Gene:	LOC798168 / 798168	-ID:	-	Length:	739	Species:	Danio rerio

Alignment Length:	546	Identity:	156/546 - (28%)
Similarity:	251/546 - (45%)	Gaps:	63/546 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK--LVTKDGNSLLIGA 111
            ||     ..|:.:|.....|.::||::....|..:.:..:.:.|.:.:..  |::.|.::|.:||
Zfish     8 WM-----FKVIFLGLIDPSQASVRPRVSFARGSSERVLGIYSSSTLKNTSTLLLSTDEDTLFVGA 67

  Fly   112 RNTVFNLSI---HDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNS 173
            |:.:|:|.:   ..:..:..|.||...|.||.|.|..|.:  |.|:|.|:...:...|:.||||:
Zfish    68 RDALFSLDVSQSDSITLKDELKWTPSSDQTKTCRVASKLD--CGNFISILQFFNSTHLYACGTNA 130

  Fly   174 FRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR---- 234
            ::|.......|..|..:: .|:.:..||:.....:|:::.|.|||:.|...|.|...:|.|
Zfish   131 YKPQAIIIPASSLNANID-KKDAKNCCPFSSTQRNTAIIVDGELYTATNVGFFGDKNVISRCHSR 194

  Fly   235 ---EPLQTEQYDSLSLNAPNFVSS---FTQGDFVYFFFRETAVEFINCGKAI-YSRVARVCKWDK 292
               ..|:.|....| |..|.|:||   .::|..:.||.....:.....|.:. .||||:||..|.
Zfish   195 GTHNNLELETVPKL-LQEPVFISSTHVASEGKILLFFTENGDLSGDYFGNSFTVSRVAQVCTDDN 258

  Fly   293 GGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPG 357
            ||....:.|||||.|::|.|....|  ..||::|....|......|....|.||||.:..:...|
Zfish   259 GGTLTLQRRWTSFAKAQLVCQQGED--LQFNKLQDIVKLSPSDSDSPDKTLFYGVFTSQRSVSSG 321

  Fly   358 -SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--HNDSRALPDPTLNFIKT 419
             ||||||:|.||...|.|.:|......::|.|..|.   |.:.|.|  .||:    |..||.:|
Zfish   322 LSAVCAFSLTDIKAAFSGNYKTFDLRGNHWSPQPNT---DGKLGKCGLFNDT----DSVLNRVK- 378

  Fly   420 HSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSV-NAESA 483
            .|.:.|||.....:.:|: :|...::|::||. :.:...|:||.::::.|:.|.:.|.| .||..
Zfish   379 KSFLTENVVHPMDKTLLL-SSAEEQYTRLAVH-RAQAVDGQTYTILYLLTESGFLHKVVLLAEGP 441

  Fly   484 DSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHN 548
            .        :||||.:..:.:..:|:.:            |.....|.|.:...|..:.|..|
Zfish   442 H--------IIEEIQIFKQPQIAKNILL------------SKSKSVLFIGSSEGVFRVPLSNC-- 484

  Fly   549 DKITSCSECVALQDPYCAWDKIAGKC 574
            ....:|:|||..:||:||||.....|
Zfish   485 SAYPNCAECVLARDPFCAWDTETRAC 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	136/474 (29%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/30 (40%)
LOC798168	XP_009290884.1	Sema_4	43..482	CDD:200501	135/474 (28%)
		PSI	483..527	CDD:214655	12/30 (40%)
		Ig_Sema4B_like	540..624	CDD:143280
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010