Protein Alignment Sema1a and sema4e

DIOPT Version :10

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_571124.2
• Gene: sema4e / 796377
• ZFINID: ZDB-GENE-990715-7
• Length: 766
• Species: Danio rerio
• Alignment Length: 745
• Identity: 210/745 - (28%)
• Similarity: 344/745 - (46%)
• Gaps: 137/745 - (18%)

  Fly    50 MQVFLLLTVLVI-------GNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDG-NS 106
            |.:..:|.||.:       |...:..::: |:..|.:|......| ..|.:.::..::.:|. |.
Zfish     2 MSLLAVLCVLYVWSPAMLTGGLGSTLDSL-PRKTVPIGSNGGRLF-REEGIWNYTTMLLRDDLNL 64

  Fly   107 LLIGARNTVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLFVC 169
            |::|||..:|.|.:.|: :::..|.|....|....|..|||| ...|:|||||:.....||::||
Zfish    65 LILGAREAIFALDLDDITIKKAMLKWEVTRDQQNDCSNKGKDATNDCKNYIRILHKKDDGRMYVC 129

  Fly   170 GTNSFRPMCNTYIISDSNYTLE-ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIY 233
            ||.:|.|.|.....:|...||| ..::.:..||:||....||.:.|...||.|..:|.||:|::.
Zfish   130 GTKAFNPTCGYLSYADGKLTLEILQEDTKGKCPFDPFQRYTSAMVDGAYYSATSMNFRGSEPVMM 194

  Fly   234 R---EPLQTEQYDSLSLNAPNFV--SSFTQG--------DFVYFFFRETAVEFINCGKAIYSRVA 285
            |   |.::|| :.|..|:.|||:  :...:|        |.:|.||.|||||:.:..|...||||
Zfish   195 RSTEESIRTE-FTSTWLSEPNFIHMAHIPEGQSNPDGDDDKIYLFFSETAVEYESYTKVDVSRVA 258

  Fly   286 RVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-DYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFN 349
            ||||.|.||....:.:||||||:||:|.:|. :.|..   :|...:|....:   ::.:.|.||.
Zfish   259 RVCKGDLGGQRTLQKKWTSFLKARLDCQVPNTNLPLL---VQDVFHLCPDDW---TTCVFYAVFT 317

  Fly   350 TPSNSIPGSAVCAFALQDIADTF-EGQFKEQTGINSN---WLPVNNAKVPDPRPGSCHND----- 405
            ..|:|...||||::.::||...| :|:||....:.::   |: :.:.::||||||:|.::
Zfish   318 PQSDSSQYSAVCSYKIEDIKTVFSKGKFKAPFNVETSFVKWV-MYSGELPDPRPGACIDNHARQK 381

  Fly   406 ----SRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIF 466
                |..|||.||.|:|...|||:.|.|  .||:||:...  .||:|.|...... .|.::.|:|
Zfish   382 GITKSLELPDKTLQFVKDKPLMDQAVTA--EQPLLVKRGA--AFTRIVVTTATAL-NGTSHQVMF 441

  Fly   467 VGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLI 531
            :||..|.::|:||...       ..|::|||.:...||||:.|.:            |....:|.
Zfish   442 IGTKSGSVLKAVNYNG-------EMVIMEEIQLFEPSEPIKILRL------------SSSKKQLY 487

  Fly   532 IVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ 596
            :.::..||.:.:..|  .:..:|.:||..:||:|.||.....|.:..:......:...|:::.|.
Zfish   488 VGSEVGVVQLSISEC--GQYQTCLDCVLARDPHCGWDLDTEHCATINSIHRTRSSTVIQSLSDGD 550

  Fly   597 HAACPSGKINSKDANA--------------------------GEQKGFRNDMDLLD--------- 626
            .:.||:..: ||..|.                          ||.....|.:.:|.
Zfish   551 ASQCPAIGV-SKPVNISFYHGNTVKLGCQPYSNLAQVEWQLNGEPIKPSNTIQILSDGLMIFNAS 614

  Fly   627 ---------------SRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLV-MAVLAGSIFSL 675
                           |:|:.:.|.:..:: |.:.....:|.:.:.:....||| |.|:...:.:.
Zfish   615 LDATGYYICSSIETVSQRKYQTQHVAYDV-KMWSESGTTASLHHVKEKERTLVAMVVILSLVLAA 678

  Fly   676 LV--GFFTGYF---CGRRCHKD-----EDD 695
            |:  ..:.|:.   |..|..||     |||
Zfish   679 LLIWNLYKGHLSLPCLHRRVKDTQNRHEDD 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	161/485 (33%)
		PSI	545..601	CDD:396154	12/55 (22%)
sema4e	NP_571124.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	724..750