DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sema1a and SEMA4A

DIOPT Version :9

Sequence 1:NP_001260265.1 Gene:Sema1a / 34192 FlyBaseID:FBgn0011259 Length:1131 Species:Drosophila melanogaster
Sequence 2:NP_001180229.1 Gene:SEMA4A / 64218 HGNCID:10729 Length:761 Species:Homo sapiens


Alignment Length:711 Identity:217/711 - (30%)
Similarity:327/711 - (45%) Gaps:98/711 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPE-DVLKFVGNESVVD-HFKLVTKDGNSLLIGAR 112
            :|:.|..|....|.|..     .|::....|.| ..|.|...:.:.| ...|::.|||:|.:|||
Human    22 LQLLLPTTTAGGGGQGP-----MPRVRYYAGDERRALSFFHQKGLQDFDTLLLSGDGNTLYVGAR 81

  Fly   113 NTVFNLSIHD--LVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGTNS 173
            ..:..|.|.|  :...:.:: |.:.:.....|..|.|..|. |.|:||::|..:...|:.|||.:
Human    82 EAILALDIQDPGVPRLKNMIPWPASDRKKSECAFKKKSNETQCFNFIRVLVSYNVTHLYTCGTFA 146

  Fly   174 FRPMCNTYIISDSNYTLEATKN----GQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR 234
            |.|.| |:|....:|.|..:::    |:...|:||.|..|:||.|..|||||:.:|.||:||:.|
Human   147 FSPAC-TFIELQDSYLLPISEDKVMEGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMR 210

  Fly   235 ----EP-LQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGG 294
                :| |:|:.:.....:..:||::......|||||.|||.||....:...||||||||.|.||
Human   211 TLGSQPVLKTDNFLRWLHHDASFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGG 275

  Fly   295 PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPG-- 357
            ....:.:||:|||::|.|:.||..|  ||.|:.|..|   ...|.::..||.|| |....:.|  
Human   276 EKLLQKKWTTFLKAQLLCTQPGQLP--FNVIRHAVLL---PADSPTAPHIYAVF-TSQWQVGGTR 334

  Fly   358 -SAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHS 421
             ||||||:|.||...|:|::||.....|.|......:. :||||||.....:  |..|.|:|.|.
Human   335 SSAVCAFSLLDIERVFKGKYKELNKETSRWTTYRGPET-NPRPGSCSVGPSS--DKALTFMKDHF 396

  Fly   422 LMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSA 486
            ||||.|   ...|:||::...|  |::||:. .:...|.::.|:::||..|.:.|:|  .|.|| 
Human   397 LMDEQV---VGTPLLVKSGVEY--TRLAVET-AQGLDGHSHLVMYLGTTTGSLHKAV--VSGDS- 452

  Fly   487 DKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKI 551
               ::.::|||.:....||:|||::..|            .|.:.:.....|..:....|  ...
Human   453 ---SAHLVEEIQLFPDPEPVRNLQLAPT------------QGAVFVGFSGGVWRVPRANC--SVY 500

  Fly   552 TSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQ-HAACPSGKINSKDANAGEQ 615
            .||.:||..:||:||||..:..|....||..   |.:.|::..|. ..||.||.::.        
Human   501 ESCVDCVLARDPHCAWDPESRTCCLLSAPNL---NSWKQDMERGNPEWACASGPMSR-------- 554

  Fly   616 KGFRNDMDLLDSRRQSKDQEI-----IDNIDKNFEGPQISADIINAQY------TVETLVMAVLA 669
                      ..|.||:.|.|     :.|.......|.:||  :.:.|      .|......|..
Human   555 ----------SLRPQSRPQIIKEVLAVPNSILELPCPHLSA--LASYYWSHGPAAVPEASSTVYN 607

  Fly   670 GSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLP 730
            ||:..::.....|.:   :|...| :...||...|....|.|.:...|....|.:|...:|
Human   608 GSLLLIVQDGVGGLY---QCWATE-NGFSYPVISYWVDSQDQTLALDPELAGIPREHVKVP 664

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema1aNP_001260265.1 Sema_1A 91..546 CDD:200498 160/471 (34%)
PSI 545..>579 CDD:214655 12/33 (36%)
SEMA4ANP_001180229.1 Sema_4A 55..495 CDD:200517 161/473 (34%)
PSI 496..541 CDD:214655 16/49 (33%)
Ig 566..638 CDD:353325 14/77 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..749
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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