DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and SEMA3F

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_004177.3	Gene:	SEMA3F / 6405	HGNCID:	10728	Length:	785	Species:	Homo sapiens

Alignment Length:	849	Identity:	220/849 - (25%)
Similarity:	362/849 - (42%)	Gaps:	199/849 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAW-----QENIRPKLYVELGPEDVLKFVGNESVVDHF------------KLVT 101
            ||...|:.|   ||     |:::.....|.|..:: ||..|..    ||            .|..
Human     7 LLWASLLTG---AWPSFPTQDHLPATPRVRLSFKE-LKATGTA----HFFNFLLNTTDYRILLKD 63

  Fly   102 KDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPG 164
            :|.:.:.:|:::.|.:|.:||:..:..:: |.:.....:.|::.|||... |.|::|::...:..
Human    64 EDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIEECVLSGKDVNGECGNFVRLIQPWNRT 128

  Fly   165 RLFVCGTNSFRPMCNTYI------------------------------------ISDSNYTLEAT 193
            .|:||||.::.||| ||:                                    ..|..:.||..
Human   129 HLYVCGTGAYNPMC-TYVNRGRRAQATPWTQTQAVRGRGSRATDGALRPMPTAPRQDYIFYLEPE 192

  Fly   194 K--NGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPN 251
            :  :|:..|||||:.::.|.|.:.|||:|...||.|:|..|:|     ..::|:||:|..||.|:
Human   193 RLESGKGKCPYDPKLDTASALINEELYAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPS 257

  Fly   252 FV-------SSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSR 309
            |:       |:....|.:||||||.:.|... ..|:|:|:.|:|..|.||.....|:|::|||:|
Human   258 FIHAELIPDSAERNDDKLYFFFRERSAEAPQ-SPAVYARIGRICLNDDGGHCCLVNKWSTFLKAR 321

  Fly   310 LNCSIPGD--YPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTF 372
            |.||:||:  ...:|:|:|   ::...|...:.:.:||.||.:..:...|||||.:::.||...|
Human   322 LVCSVPGEDGIETHFDELQ---DVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVF 383

  Fly   373 EGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPA 429
            .|.|..:.|.|..|:|. :.|:|.||||:|        ...::..||..:||:::|.||.:.|..
Human   384 NGPFAHKEGPNYQWMPF-SGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYP 447

  Fly   430 FFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVI 494
            ...:|::|||...||.|.|||| |:....|: |:|:|:|||.|.:.|.:.....|  .::..:::
Human   448 LQRRPLVVRTGAPYRLTTIAVD-QVDAADGR-YEVLFLGTDRGTVQKVIVLPKDD--QELEELML 508

  Fly   495 EEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVA 559
            ||::|.....|::.:.|....|            :|.:.:...|..:.||||.... .:|::|..
Human   509 EEVEVFKDPAPVKTMTISSKRQ------------QLYVASAVGVTHLSLHRCQAYG-AACADCCL 560

  Fly   560 LQDPYCAWD-------KIAGKCRS------HGAP----RWLEENYFYQNVATGQHAACPSGKI-- 605
            .:|||||||       ..:.|.||      ||.|    |....|.....|.:.|:....|...
Human   561 ARDPYCAWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFLE 625

  Fly   606 ---NSKDANA----------------GEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISA 651
               .|..|..                .|.:..|.:..||....|..|:.:.          ..:|
Human   626 CQPRSPQATVKWLFQRDPGDRRREIRAEDRFLRTEQGLLLRALQLSDRGLY----------SCTA 680

  Fly   652 DIINAQYTVETLVMAVLA-----GSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQ 711
            ...|.::.|..:.:.||.     .::|..|                 ..:.|.|.
Human   681 TENNFKHVVTRVQLHVLGRDAVHAALFPPL-----------------SMSAPPPP---------- 718

  Fly   712 NVNSFPSSCRIQQEPKLLPQVEE---VTYAEPVLLPQPPPPNKM----HSPKNTLRKPPMHQMHQ 769
              .:.|.:...|:..:||.|.|.   ..|.:......||.|.:.    .||:...:|.|.::.|.
Human   719 --GAGPPTPPYQELAQLLAQPEVGLIHQYCQGYWRHVPPSPREAPGAPRSPEPQDQKKPRNRRHH 781

  Fly   770 GPNS 773
            .|::
Human   782 PPDT 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/528 (29%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	15/46 (33%)
SEMA3F	NP_004177.3	Sema_3F	48..548	CDD:200515	151/521 (29%)
		PSI	547..584	CDD:214655	12/37 (32%)
		Ig_Semaphorin_classIII	609..697	CDD:143279	14/97 (14%)
		IG_like	612..696	CDD:214653	13/93 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..785		9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910