DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema3c

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_002933132.1	Gene:	sema3c / 613059	XenbaseID:	XB-GENE-1014800	Length:	748	Species:	Xenopus tropicalis

Alignment Length:	580	Identity:	178/580 - (30%)
Similarity:	294/580 - (50%)	Gaps:	92/580 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NESVVDH-FKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKD-EEAC 151
            ::|.:|: ..|:.:|.:.:.:|:::.:.:|:|:::......| |.:.....:.|.:.||| ...|
Frog    46 SQSPLDYRILLMDEDQDRIYVGSKDHILSLNINNISHDPLSVFWPASTSKVEECKMAGKDPTHGC 110

  Fly   152 QNYIRIMVVPSPGRLFVCGTNSFRPMCNTYI-----ISDSNYTLE-ATKNGQAVCPYDPRHNSTS 210
            .|::|::...:...|:|||:.:|.|:| |||     ..|..:.:: ..::|:..|.::|:.|:.|
Frog   111 GNFVRVIQNFNRTHLYVCGSGAFSPVC-TYINRGRRSEDHIFAIDYKNESGKGRCSFNPKVNTVS 174

  Fly   211 VLADNELYSGTVADFSGSDPIIY-----REPLQTEQYDSLSLNAPNFVSSFTQGD-------FVY 263
            |:.:.||:||...||.|:|..|:     |..::|:|::|..|:.|.||.:....|       .||
Frog   175 VMINEELFSGMYIDFMGTDSAIFRSLTKRNAVRTDQHNSKWLSEPIFVDAQLLPDGTDPNDAKVY 239

  Fly   264 FFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGD--YPFYFNEIQ 326
            ||.:|...:.....|.|:|.:||||..|.||.....|:||:|||:||.||:..|  ...||:|::
Frog   240 FFLKERLTDNSGSTKQIHSMIARVCPNDIGGQRSLVNKWTTFLKARLVCSVMDDDGTETYFDELE 304

  Fly   327 SASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNN 391
            ... |:|..  :..:.|:||:|.|.|:...|||||.:.:.||...|.|.|..:.|.|...:|. .
Frog   305 DVF-LMETD--NPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVFNGPFAHKEGPNHQLIPY-Q 365

  Fly   392 AKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQI 448
            .::|.||||:|        ...::..||..:.||:.|.||..::.....:|:|:||.|.|:||:|
Frog   366 GRIPYPRPGTCPGGAFTPNMKSTKEFPDDVVTFIRNHPLMFNSIYPTLKRPLLIRTGTDYKFTKI 430

  Fly   449 AVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVR 513
            .|| ::....|| |.|:|:|||.|.:.|.|...:..||.  ..:::||::|.....||.:::|..
Frog   431 VVD-RVNAADGK-YHVLFLGTDKGTVQKVVVVPANGSAS--GELILEEMEVFKSHAPITSMKISS 491

  Fly   514 TMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKI--TSCSECVALQDPYCAWDKIAGKCRS 576
            ..|            :|.:.::..:..:.|||||   |  |:|::|...:|||||||   ||..|
Frog   492 KKQ------------QLYVSSEEGITQLSLHRCH---IYGTACADCCLARDPYCAWD---GKFCS 538

  Fly   577 HGAPRWLEENYFYQNVATGQHAACPSGKINSK--DANAGEQ---------KGFRNDMDLL 625
            .          ||           ||||..|:  |...|..         ||:||..:::
Frog   539 R----------FY-----------PSGKRRSRRQDVKHGNPVTQCRGFNLKGYRNTAEIV 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	148/485 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	17/35 (49%)
sema3c	XP_002933132.1	Sema_3C	43..512	CDD:200512	148/486 (30%)
		PSI	511..548	CDD:214655	23/63 (37%)
		Ig_Semaphorin_classIII	573..662	CDD:143279	0/5 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100