Protein Alignment Sema1a and SEMA4G

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: NP_060363.2
• Gene: SEMA4G / 57715
• HGNCID: 10735
• Length: 843
• Species: Homo sapiens
• Alignment Length: 1091
• Identity: 255/1091 - (23%)
• Similarity: 385/1091 - (35%)
• Gaps: 347/1091 - (31%)

  Fly    45 YGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK---------LV 100
            :|..|..:..:||...:...|.    .||...::..|...:.: ...|...|||         |:
Human     2 WGRLWPLLLSILTATAVPGPSL----RRPSRELDATPRMTIPY-EELSGTRHFKGQAQNYSTLLL 61

  Fly   101 TKDGNSLLIGARNTVFNLSIHDLVE--QQRLVW-TSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            .:....||:|||..:|:||.:|:.:  .:.:.| .|||..:| |..|||:.:. |.|::|.:...
Human    62 EEASARLLVGARGALFSLSANDIGDGAHKEIHWEASPEMQSK-CHQKGKNNQTECFNHVRFLQRL 125

  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEAT-KNGQAVCPYDPRHNSTSVLADNELYSGTVADF 225
            :...|:.|||::|:|:|..  |....:||..: :.|:..|||||....|.::.|..||:.|..:|
Human   126 NSTHLYACGTHAFQPLCAA--IDAEAFTLPTSFEEGKEKCPYDPARGFTGLIIDGGLYTATRYEF 188

  Fly   226 SGSDPIIYR----EPLQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFFRETAVEFINC 276
            . |.|.|.|    ..|:||:.....||...||          |:....|.||:||.|.|.|.
Human   189 R-SIPDIRRSRHPHSLRTEETPMHWLNDAEFVFSVLVRESKASAVGDDDKVYYFFTERATEE--- 249

  Fly   277 GKAIY---------SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLV 332
            |...:         :|||||||.|.||....:.:||||||:||.|.||     .:..::...:|
Human   250 GSGSFTQSRSSHRVARVARVCKGDLGGKKILQKKWTSFLKARLICHIP-----LYETLRGVCSL- 308

  Fly   333 EGQYGSMSSKLIYGVF--NTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVP 395
            :.:..|.:.  .|..|  :|...::..||:|.:.|.:|...|.|.:.|....:..|...... ||
Human   309 DAETSSRTH--FYAAFTLSTQWKTLEASAICRYDLAEIQAVFAGPYMEYQDGSRRWGRYEGG-VP 370

  Fly   396 DPRPGSC---------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVD 451
            :||||||         :|.|:.||...|:|:|.|.||...|.....:|:|::.:  .|:|.: ..
Human   371 EPRPGSCITDSLRSQGYNSSQDLPSLVLDFVKLHPLMARPVVPTRGRPLLLKRN--IRYTHL-TG 432

  Fly   452 AQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQ 516
            ..:.||.|.|||::|:||..|.|.|:|...|.       ..:|||..|..:|:.:.|| ::..:|
Human   433 TPVTTPAGPTYDLLFLGTADGWIHKAVVLGSG-------MHIIEETQVFRESQSVENL-VISLLQ 489

  Fly   517 YDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPR 581
            :           .|.:...|.|:.:.|..|  .:..||.:|:..:||||.||
Human   490 H-----------SLYVGAPSGVIQLPLSSC--SRYRSCYDCILARDPYCGWD------------- 528

  Fly   582 WLEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEG 646
                        .|.||...:..|    ||                |.|.....:|.:|::.
Human   529 ------------PGTHACAAATTI----AN----------------RSQGSRTALIQDIERG--- 558

  Fly   647 PQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQ 711
                                                   .|.|....|...|.|
Human   559 ---------------------------------------NRGCESSRDTGPPPP----------- 573

  Fly   712 NVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNSETL 776
                              .:...|...:.||||...|.|...:
Human   574 ------------------LKTRSVLRGDDVLLPCDQPSNLARA---------------------- 598

  Fly   777 FQFQPDGYNTQQSYRGRDNFGTLRSHQVMGD---NYRRG-DGFSTTRSVKKAVNNTNTRNRSLGR 837
                               ...|.....:.|   .||.| ||...|.:
Human   599 -------------------LWLLNGSMGLSDGQGGYRVGVDGLLVTDA----------------- 627

  Fly   838 ARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPS-SSPSPQESPK-NCS 900
               ||       :|..|.....::...:...:|.|..|.. ::.:|||.: ::|..|.:|. ...
Human   628 ---QP-------EHSGNYGCYAEENGLRTLLASYSLTVRP-ATPAPAPKAPATPGAQLAPDVRLL 681

  Fly   901 YIYRDXLICNTKSMPLIQAQSTHAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGRTYAKSMPVT 965
            |:   ..|.....:.||.|.|             |..........:.|.|...:||  |.....:
Human   682 YV---LAIAALGGLCLILASS-------------LLYVACLREGRRGRRRKYSLGR--ASRAGGS 728

  Fly   966 PVQPQSPLAETPSYELYERHSDAATFHFGDEDDDDDDEHDHEDTSSLAMI------TPPPPYDTP 1024
            .||.|:...:.|                |:||:.||:.....:.|.|.:|      .||||
Human   729 AVQLQTVSGQCP----------------GEEDEGDDEGAGGLEGSCLQIIPGEGAPAPPPP---- 773

  Fly  1025 HLIASPPLPPP--------------RRFRFGNRELFSMSPAGGGATPTASA 1061
                 ||.|||              ||....:..|...|..|..|.|.:.|
Human   774 -----PPPPPPAELTNGLVALPSRLRRMNGNSYVLLRQSNNGVPAGPCSFA 819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	153/502 (30%)
		PSI	545..>579	CDD:214655	10/33 (30%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	151/496 (30%)
		PSI	507..557	CDD:307546	20/96 (21%)
		Ig_Sema4B_like	572..655	CDD:143280	22/179 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..782		21/78 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910