Protein Alignment Sema1a and SEMA6A

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_006714726.1
• Gene: SEMA6A / 57556
• HGNCID: 10738
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 1117
• Identity: 295/1117 - (26%)
• Similarity: 455/1117 - (40%)
• Gaps: 329/1117 - (29%)

  Fly    13 SASNSNYNKGHKMHLKSATAKATIMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYV 77
            |.|:.||.|.:.:.:.....:.|..:|:|.       :|:.:::
Human    28 SISHGNYTKQYPVFVGHKPGRNTTQRHRLD-------IQMIMIM--------------------- 64

  Fly    78 ELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNLSI-----HDLVEQQRLVWTSPEDD 137
                                      ..:|.|.||:.::.:.|     .::...::|.|.|.:.|
Human    65 --------------------------NGTLYIAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQAD 103

  Fly   138 TKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEA---TKNGQAV 199
            ...|.:|||.::.|.|:|::::..:...|||||||:|.|.|..|.:.    |||.   ..:|.|.
Human   104 VDTCRMKGKHKDECHNFIKVLLKKNDDALFVCGTNAFNPSCRNYKMD----TLEPFGDEFSGMAR 164

  Fly   200 CPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQG 259
            ||||.:|.:.::.||.:|||.||.||...|.:|||.     .|:|.::||..|..|.||.:...|
Human   165 CPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGESPTLRTVKHDSKWLKEPYFVQAVDYG 229

  Fly   260 DFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFN 323
            |::||||||.|||:...||.::.|||:|||.|.||..| ...:||||||:|||||:|||..||||
Human   230 DYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFN 294

  Fly   324 EIQSASNL--VEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNW 386
            .:|:.:::  :.|:      .::...|:||.||||||||||:.:.|||..|.|:||||...:|.|
Human   295 ILQAVTDVIRINGR------DVVLATFSTPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTW 353

  Fly   387 LPVNNAKVPDPRPGSC--------HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIY 443
            .||.:.:||.||||.|        :..|...||.||||||||.||||.||:.|::|..:||...|
Human   354 TPVPDERVPKPRPGCCAGSSSLERYATSNEFPDDTLNFIKTHPLMDEAVPSIFNRPWFLRTMVRY 418

  Fly   444 RFTQIAVDAQIKTPGG--KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKS--- 503
            |.|:||||    |..|  :.:.|:|:|::.|.|:|.: |...:|.....|:.:||:.|....
Human   419 RLTKIAVD----TAAGPYQNHTVVFLGSEKGIILKFL-ARIGNSGFLNDSLFLEEMSVYNSEKCS 478

  Fly   504 -EPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCA 566
             :.:.:..|: .||.|:.....|      :...:.|:.:.|.||  ::...|.: |:|.:||||.
Human   479 YDGVEDKRIM-GMQLDRASSSLY------VAFSTCVIKVPLGRC--ERHGKCKKTCIASRDPYCG 534

  Fly   567 WDKIAGKCRSHGAPRWLEENYFYQNVATGQ----------------------------------- 596
            |.|..|.| ||.:|.  ....|.|::..|.
Human   535 WIKEGGAC-SHLSPN--SRLTFEQDIERGNTDGLGDCHNSFVALNEANILFIMCMVIILQGWSFW 596

  Fly   597 ---HAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDK-------NFEGPQISA 651
               |::.......:.|:.|  |:|:.:...:||.:      .::|:.|.       :....|...
Human   597 SCWHSSSLLPSTTTSDSTA--QEGYESRGGMLDWK------HLLDSPDSTDPLGAVSSHNHQDKK 653

  Fly   652 DIINAQY--------TVETLVMAVL----AGSIFSLLVGF------------------------- 679
            .:|...|        .|..|.:||:    .|::||.:..:
Human   654 GVIRESYLKGHDQLVPVTLLAIAVILAFVMGAVFSGITVYCVCDHRRKDVAVVQRKEKELTHSRR 718

  Fly   680 --------FTGYFCGRRCHKDEDDN----------------------------------LPYPDT 702
                    .:|.| |....||....                                  ||.|::
Human   719 GSMSSVTKLSGLF-GDTQSKDPKPEAILTPLMHNGKLATPGNTAKMLIKADQHHLDLTALPTPES 782

  Fly   703 E------------YEYFEQRQN-VNS------------FPSSCRIQQEPKLLPQVEEVTYAEPVL 742
            .            ...:|:.|| :|:            .|:...::..|..:|.|        |:
Human   783 TPTLQQKRKPSRGSREWERNQNLINACTKDMPPMGSPVIPTDLPLRASPSHIPSV--------VV 839

  Fly   743 LP---QPPPPNKMHSPK------------------NTLR-----KPPMHQMHQGPNSETL----- 776
            ||   |......:..||                  .|::     |.|.|.::...|.::|
Human   840 LPITQQGYQHEYVDQPKMSEVAQMALEDQAATLEYKTIKEHLSSKSPNHGVNLVENLDSLPPKVP 904

  Fly   777 ---FQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRG-DGFSTTRSVKKAV---NNTN----- 829
               ....|.|.:..|:  |......:......|.:|:|. ...|.|||.:...   ||||
Human   905 QREASLGPPGASLSQT--GLSKRLEMHHSSSYGVDYKRSYPTNSLTRSHQATTLKRNNTNSSNSS 967

  Fly   830 --TRNRSLGRARRQPP---RHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSPA-PPSS 888
              :||:|.||....||   |...:..|.|....|....|:||..::.:|...|....:|: .|..
Human   968 HLSRNQSFGRGDNPPPAPQRVDSIQVHSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDV 1032

  Fly   889 SPSPQESPKNCS 900
            .|.|..:|.:.|
Human  1033 PPKPSFAPLSTS 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	183/484 (38%)
		PSI	545..>579	CDD:214655	15/34 (44%)
SEMA6A	XP_006714726.1	Sema_6A	48..513	CDD:200527	186/540 (34%)
		PSI	514..>544	CDD:307546	13/32 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1252
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	373	1.000	Inparanoid score	I2116
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm8465
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	LDO	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4157
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.850