DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema4ba

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001121824.1	Gene:	sema4ba / 572261	ZFINID:	ZDB-GENE-070705-31	Length:	830	Species:	Danio rerio

Alignment Length:	1009	Identity:	271/1009 - (26%)
Similarity:	425/1009 - (42%)	Gaps:	305/1009 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 QVF--LLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFK----------LVTKD 103
            :||  .||.||::|...:.::::.|:|        ...:..||.....|.          |::|:
Zfish     8 RVFFLFLLNVLLVGRCQSAEDDVTPRL--------SFSYNANERSAKRFSPSGVFNYTSLLLSKE 64

  Fly   104 GNSLLIGARNTVFNLSIHDLVE---QQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPG 164
            .|.|.:|||.|:|.|:|.|:..   |:.|.|::|:.....|..|||| :..|.|||:|::..:..
Zfish    65 DNMLYVGARETLFALNISDISRTQMQRNLTWSTPQRKRDECSFKGKDLKTDCFNYIKILLRVNST 129

  Fly   165 RLFVCGTNSFRPMCNTYIIS--DSNYTLE-------ATKNGQAVCPYDPRHNSTSVLADNELYSG 220
            .|:||||.:|.|:| |||:|  .||::|.       .|::|::.|||:|.:.||:::||.|||:|
Zfish   130 HLYVCGTYAFSPIC-TYIVSTNTSNFSLVRNEVGEIMTEDGRSRCPYNPEYKSTAIMADGELYAG 193

  Fly   221 TVADFSGSDPIIYRE-----PLQTEQYDSLS-LNAPNFV-SSFTQ-----------GDFVYFFFR 267
            ||::|.|:|||||:.     .|:||  :||: |..|.|| |::.|           .|.:||||.
Zfish   194 TVSNFQGNDPIIYKSLGQGTALKTE--NSLNWLQDPAFVGSAYIQESLPKGNAVGDDDKIYFFFS 256

  Fly   268 ETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGD-YPFYFNEIQSASNL 331
            |...||......|.||:|||||.||||....:.:||:|||::|.||:|.| :||         |:
Zfish   257 EAGKEFDFFDNTIVSRIARVCKGDKGGERVLQKKWTTFLKAQLLCSLPDDGFPF---------NI 312

  Fly   332 VEGQYGSMSSK------LIYGVFNTP--SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLP 388
            ::..:....||      :.||||.:.  ..:...||||||.:..:.:.|.|:::|.......|..
Zfish   313 IQDMFVLTPSKEDWKKTMFYGVFTSQWYKGASGSSAVCAFTMDQVEEAFNGRYREVNRETQQWYT 377

  Fly   389 VNNAKVPDPRPGSC-HNDSRA--------LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYR 444
            .|: .||:||||:| .|.:||        :||..|||:|.|.|||..:.   |||:|::.:.  |
Zfish   378 YNH-PVPEPRPGACITNTARAQGISSSLHMPDRVLNFVKDHFLMDNVIR---SQPLLLKRNV--R 436

  Fly   445 FTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNL 509
            :||:||. :::.. .|||||:|:|||.|:|.|::|.       |....:|||:.:..:.:.::::
Zfish   437 YTQLAVH-RVQAL-HKTYDVLFIGTDDGRIHKAINV-------KNKMYIIEELVIFPEPQSVQHI 492

  Fly   510 EIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC 574
            |:      |..|      |.|.:.:.|.:|.|.|..|.|  ..||.|||..:||||||
Zfish   493 EL------DDEK------GLLFVSSYSGLVEIPLANCSN--YQSCGECVLSRDPYCAW------- 536

  Fly   575 RSHGAPRWLEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDN 639
                               ||:..:      |.|.|::..|              ..:|.|..:.
Zfish   537 -------------------TGKQCS------NVKHASSKSQ--------------WQQDVEDANT 562

  Fly   640 IDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRC-HKDEDDNLPYPDTE 703
            .......|:.....:.|.:.||      :..:.|::|..........||. :.|..:...||..:
Zfish   563 AICKMPSPRSGRPRVPACHVVE------IPANTFTVLPCKLRSNLAARRWEYSDTAERFVYPSPD 621

  Fly   704 --------------YEYFEQRQNVNSFPSS-C-RIQQEPKLL---PQVEEVTYAEPVLLPQPPPP 749
                          |..:.:..|.....:| | :.:.|...|   .:.::||..|.:|      |
Zfish   622 GGLVVVAQVDRQENYACWSEEGNYRQLLASYCVKAEHESTTLTGRSRTQQVTQGETIL------P 680

  Fly   750 NKMHSPKNTLRKPPMHQMHQGPNSET----------LFQFQPDGYNTQQSYRGRDNFGTLRSHQV 804
            .:..||:.|               :|          |..|.....:...:||.||..
Zfish   681 GETWSPQKT---------------KTYWNELIVVCALLVFSLVVLSLFVAYRNRDRM-------- 722

  Fly   805 MGDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSS 869
                          :|:.|                            ....|..||::.:.|...
Zfish   723 --------------KSMLK----------------------------EGECPNMQQKKPRIPGKH 745

  Fly   870 SGSSPVMSNSSSSPAPPSSSPSPQESPKNCSYIYRDXLICNT------------------KSMPL 916
            :.|.|:..|:    .|||.|........|.:|      ||:|                  |.:..
Zfish   746 TESLPLNGNN----IPPSVSDHKGYQTLNDNY------ICSTPTHECSSPENSKSFSESEKRLLT 800

  Fly   917 IQAQSTHAQPHPQSHPHPLPPPGPTTPPAQPRAR 950
            :..:.:|.:            ..||.|  :||.|
Zfish   801 VNLKESHVE------------ISPTCP--RPRVR 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	182/513 (35%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/33 (39%)
sema4ba	NP_001121824.1	Sema_4B	47..515	CDD:200518	180/506 (36%)
		PSI	516..565	CDD:214655	21/96 (22%)
		Ig	578..654	CDD:299845	13/81 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010