DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema4ab

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005170153.1	Gene:	sema4ab / 571290	ZFINID:	ZDB-GENE-060503-363	Length:	836	Species:	Danio rerio

Alignment Length:	948	Identity:	238/948 - (25%)
Similarity:	393/948 - (41%)	Gaps:	240/948 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 VFLLLTVLVIGNQSAWQENIRPKLYVELGP--EDVLKFVGNESVVDHFKLVTKDGNSLLIGARNT 114
            ||||..|       ....::.|:|...:|.  ..:..|..::|......|::.|..:|.:|||:|
Zfish    11 VFLLTAV-------RCHSHVLPRLSFPMGSPGRSLTVFTNDDSYNATTLLLSNDEGTLFVGARDT 68

  Fly   115 V--FNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPM 177
            :  .|:|..|:..:::|.|:..|.|...|.:|||.:..|.|::|::.|.:...::.|||.:|.|.
Zfish    69 ILSINISQTDMTLKEKLDWSPSEKDFNDCSMKGKLKMDCHNFVRVLQVLNSTHMYACGTFAFSPR 133

  Fly   178 CNTYIISDSNYTLEA-----TKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR--- 234
            |  ..|:...:|:..     .:.|:..|||||...::::..|.|||:|||:||.|:.|:|.|
Zfish   134 C--IYINSQTFTMVTGPSGKPEEGRGRCPYDPYQKNSAITVDGELYTGTVSDFRGTRPVISRHLS 196

  Fly   235 --EPLQTEQYDSLS-LNAPNFVSS--FTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGG 294
              ..:..:..|:|. |..|.|:||  ....:.|||||.|...|:....|...||||:||..|.||
Zfish   197 EGSHVDLKLDDTLGWLEDPTFISSTYIHSEEKVYFFFSEIGKEYDFIDKFTVSRVAQVCTSDVGG 261

  Fly   295 PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSN-SIPGS 358
            ....:.|||:|.|::|.|....:.|  :|.:|...:|...:..|....|.||:|.:... ::..|
Zfish   262 QRTLQKRWTTFAKAQLLCQADQELP--YNVLQDVISLSPPEGASEDETLFYGIFTSQWRVNLGRS 324

  Fly   359 AVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD--PRPGSC--HNDSRALPDPTLNFIKT 419
            |||||:|:||...|.|::|........|    :.:|.:  ..||.|  ||.|    |.||.|:|.
Zfish   325 AVCAFSLKDIKKVFTGRYKVLNRDTLKW----STRVQEQMANPGECGLHNAS----DNTLRFVKD 381

  Fly   420 HSLMDENVPAFFSQPI---LVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAE 481
            :.|.|::|     .|:   |...|....::.||.. :::...||.|.|:::.|:.|.:.|:|..
Zfish   382 NFLADKSV-----LPVNQGLTVVSPDKSYSNIAAQ-RVQGARGKYYTVLYLLTESGFLHKTVLL- 439

  Fly   482 SADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRC 546
                  |..:.:||||.|..:.:.:::|.:            |...|.::|.:...::::.:..|
Zfish   440 ------KKGAHIIEEIQVFHQPQMVKSLLL------------SVSKGAVLIGSSEGLLSVPVSNC 486

  Fly   547 HNDKITSCSECVALQDPYCAWD-----------------------KIAGKCRS------HGAPRW 582
            .:.:  ||:|||..:||:|.||                       |::.:|.|      .|.|
Zfish   487 SHYR--SCAECVLARDPFCGWDLSQRVCKLITTSQNQLAQDVDEGKVSEQCSSVNLRSRSGQP-- 547

  Fly   583 LEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGP 647
                   ||..|    .||.|::.|...|                       |:|     |.:.|
Zfish   548 -------QNTQT----LCPPGEVLSVSLN-----------------------EVI-----NLQCP 573

  Fly   648 QISA------DIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEY 706
            :.|.      :.:|:|.:.:..:.:| .||:..:......|::.   |...|:.   |..|...|
Zfish   574 EASNLAKCHWERLNSQLSPKIFIQSV-NGSLSFVATPSTLGHYL---CQAVENG---YTQTLIVY 631

  Fly   707 -FEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNT-LRKPPMHQMHQ 769
             .:|:.|....|||      ||:.|...|.....|...|.        :||:| ||..|     :
Zfish   632 HIKQKNNPTILPSS------PKITPTSAEAGNKTPFSTPT--------APKHTELRPKP-----E 677

  Fly   770 GPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQ-------VMGDNYRRGD-------------- 813
            .|:|....:..| ...|::|    .||..|.|.:       ....|:::.|
Zfish   678 DPSSTVAHKDSP-ATTTRKS----KNFTPLISAEEESSWMNERSGNFKQVDKPTYLQELVVVSVL 737

  Fly   814 -----------GFSTTRSVKKAVNNTNTRNRSLGR---ARRQPPRHGIVTQH-----RSNSPQQQ 859
                       .|:..|.|        ..:|::.:   :||...:.|..|..     |.:||:.:
Zfish   738 LALCVSALLTIAFNRFRHV--------CTSRTIAQTPCSRRDVEKGGSATPQERESLRGHSPRLE 794

  Fly   860 QQQSQQPHSSS-------GSSPV-----MSNSSSSPAP 885
            ::..|.|:..|       |.|.:     |.|.|:...|
Zfish   795 KRNGQAPNGQSHIGQAHNGKSSITLSNNMLNGSNGHLP 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	141/477 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/62 (23%)
sema4ab	XP_005170153.1	Sema_4	41..484	CDD:200501	142/479 (30%)
		PSI	485..>512	CDD:214655	11/28 (39%)
		Ig	555..631	CDD:299845	19/110 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910