DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and SEMA3G

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_024309410.1	Gene:	SEMA3G / 56920	HGNCID:	30400	Length:	800	Species:	Homo sapiens

Alignment Length:	754	Identity:	210/754 - (27%)
Similarity:	325/754 - (43%)	Gaps:	117/754 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARN 113
            ||:.|  ...|:..|:||          :.|||:..|..  ....:|.::      :.|.:|..:
Human    50 WMETF--SRYLLSANRSA----------IFLGPQGSLNL--QAMYLDEYR------DRLFLGGLD 94

  Fly   114 TVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKDE-EACQNYIRIMVVPSPGRLFVCGTNSFRP 176
            .:::|.:... .:.:.::|.......:.|:.||:|. ..|.|::|::...:...|..|||.:|:|
Human    95 ALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQP 159

  Fly   177 MCNTYIISD-SNYTLE----ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR-- 234
            .|....:.. ..:.|.    :.::|:..||::|.....|...|.|||:|..|||.|.:.:|:|
Human   160 TCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSG 224

  Fly   235 --EPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFINCGK--AIYSRVARVC 288
              .|......|...|:.|.||       :|....|.|||||.|| |...:.|.  ...|||.|||
Human   225 GPRPALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSET-VPSPDGGSNHVTVSRVGRVC 288

  Fly   289 KWDKGGPHRFRNRWTSFLKSRLNCSI--PGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTP 351
            ..|.||.....|:|::|||:||.||:  ||....:|::::....|......|:.   :|.:|:|.
Human   289 VNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLE---VYALFSTV 350

  Fly   352 SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC-----------HND 405
            |....|.|||.:.:.||.:.|.|.|..:.|....|.|. ..|||.||||.|           ...
Human   351 SAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPY-GGKVPFPRPGVCPSKMTAQPGRPFGS 414

  Fly   406 SRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTD 470
            ::..||..|.|.:.|.||...|.....:|:||:|....:..||.|| :::...| ||||||:|||
Human   415 TKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVD-RVEAEDG-TYDVIFLGTD 477

  Fly   471 HGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEI--VRTMQYDQPKDGSYDDGKLIIV 533
            .|.::|.:..::..||:. ..||:||:.|.....||..:||  .|.|.|...:.|
Human   478 SGSVLKVIALQAGGSAEP-EEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLG---------- 531

  Fly   534 TDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHA 598
                |..::||:|.... |:|:||...:|||||||   |...:|..|...:..:..|::..|..|
Human   532 ----VAQLRLHQCETYG-TACAECCLARDPYCAWD---GASCTHYRPSLGKRRFRRQDIRHGNPA 588

  Fly   599 ACPSGKINSKDA----NAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDK-NFEGPQISADIINAQY 658
            ....|:...::|    .|....|..::...|:...:|....:...:.: ..|||.        |.
Human   589 LQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPD--------QV 645

  Fly   659 TVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCH---------------KDEDDNLPYPDTEYEYF 707
            ..:..|:....|.:|..|..|..| |.|....|               ..:.|||..|:.:.|..
Human   646 KTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEP 710

  Fly   708 EQRQNVNSFPSSCRIQQEPKL-----LPQVEEVTYAEPV 741
            ..|..:.|.|.....:...:|     ||:|:|  |.|.|
Human   711 PARGGLASTPPKAWYKDILQLIGFANLPRVDE--YCERV 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	146/489 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/33 (42%)
SEMA3G	XP_024309410.1	Sema_3G	67..540	CDD:200516	150/502 (30%)
		PSI	539..585	CDD:214655	16/49 (33%)
		Ig_Semaphorin_classIII	604..694	CDD:143279	17/97 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910