Protein Alignment Sema1a and SEMA3G

DIOPT Version :10

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_024309410.1
• Gene: SEMA3G / 56920
• HGNCID: 30400
• Length: 800
• Species: Homo sapiens
• Alignment Length: 754
• Identity: 210/754 - (27%)
• Similarity: 325/754 - (43%)
• Gaps: 117/754 - (15%)

  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARN 113
            ||:.|  ...|:..|:||          :.|||:..|..  ....:|.::      :.|.:|..:
Human    50 WMETF--SRYLLSANRSA----------IFLGPQGSLNL--QAMYLDEYR------DRLFLGGLD 94

  Fly   114 TVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKDE-EACQNYIRIMVVPSPGRLFVCGTNSFRP 176
            .:::|.:... .:.:.::|.......:.|:.||:|. ..|.|::|::...:...|..|||.:|:|
Human    95 ALYSLRLDQAWPDPREVLWPPQPGQREECVRKGRDPLTECANFVRVLQPHNRTHLLACGTGAFQP 159

  Fly   177 MCNTYIISD-SNYTLE----ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR-- 234
            .|....:.. ..:.|.    :.::|:..||::|.....|...|.|||:|..|||.|.:.:|:|
Human   160 TCALITVGHRGEHVLHLEPGSVESGRGRCPHEPSRPFASTFIDGELYTGLTADFLGREAMIFRSG 224

  Fly   235 --EPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFINCGK--AIYSRVARVC 288
              .|......|...|:.|.||       :|....|.|||||.|| |...:.|.  ...|||.|||
Human   225 GPRPALRSDSDQSLLHDPRFVMAARIPENSDQDNDKVYFFFSET-VPSPDGGSNHVTVSRVGRVC 288

  Fly   289 KWDKGGPHRFRNRWTSFLKSRLNCSI--PGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTP 351
            ..|.||.....|:|::|||:||.||:  ||....:|::::....|......|:.   :|.:|:|.
Human   289 VNDAGGQRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLE---VYALFSTV 350

  Fly   352 SNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC-----------HND 405
            |....|.|||.:.:.||.:.|.|.|..:.|....|.|. ..|||.||||.|           ...
Human   351 SAVFQGFAVCVYHMADIWEVFNGPFAHRDGPQHQWGPY-GGKVPFPRPGVCPSKMTAQPGRPFGS 414

  Fly   406 SRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTD 470
            ::..||..|.|.:.|.||...|.....:|:||:|....:..||.|| :::...| ||||||:|||
Human   415 TKDYPDEVLQFARAHPLMFWPVRPRHGRPVLVKTHLAQQLHQIVVD-RVEAEDG-TYDVIFLGTD 477

  Fly   471 HGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEI--VRTMQYDQPKDGSYDDGKLIIV 533
            .|.::|.:..::..||:. ..||:||:.|.....||..:||  .|.|.|...:.|
Human   478 SGSVLKVIALQAGGSAEP-EEVVLEELQVFKVPTPITEMEISVKRQMLYVGSRLG---------- 531

  Fly   534 TDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHA 598
                |..::||:|.... |:|:||...:|||||||   |...:|..|...:..:..|::..|..|
Human   532 ----VAQLRLHQCETYG-TACAECCLARDPYCAWD---GASCTHYRPSLGKRRFRRQDIRHGNPA 588

  Fly   599 ACPSGKINSKDA----NAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDK-NFEGPQISADIINAQY 658
            ....|:...::|    .|....|..::...|:...:|....:...:.: ..|||.        |.
Human   589 LQCLGQSQEEEAVGLVAATMVYGTEHNSTFLECLPKSPQAAVRWLLQRPGDEGPD--------QV 645

  Fly   659 TVETLVMAVLAGSIFSLLVGFFTG-YFCGRRCH---------------KDEDDNLPYPDTEYEYF 707
            ..:..|:....|.:|..|..|..| |.|....|               ..:.|||..|:.:.|..
Human   646 KTDERVLHTERGLLFRRLSRFDAGTYTCTTLEHGFSQTVVRLALVVIVASQLDNLFPPEPKPEEP 710

  Fly   708 EQRQNVNSFPSSCRIQQEPKL-----LPQVEEVTYAEPV 741
            ..|..:.|.|.....:...:|     ||:|:|  |.|.|
Human   711 PARGGLASTPPKAWYKDILQLIGFANLPRVDE--YCERV 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	146/489 (30%)
		PSI	545..601	CDD:396154	18/55 (33%)
SEMA3G	XP_024309410.1	Sema_3G	67..540	CDD:200516	150/502 (30%)
		PSI	539..585	CDD:214655	16/49 (33%)
		Ig_Sema3	604..694	CDD:409455	17/97 (18%)
		Ig strand A	604..609	CDD:409455	1/4 (25%)
		Ig strand B	614..622	CDD:409455	1/7 (14%)
		Ig strand C	628..634	CDD:409455	0/5 (0%)
		Ig strand C'	636..639	CDD:409455	0/2 (0%)
		Ig strand D	649..653	CDD:409455	1/3 (33%)
		Ig strand E	656..663	CDD:409455	2/6 (33%)
		Ig strand F	669..678	CDD:409455	3/8 (38%)
		Ig strand G	681..694	CDD:409455	0/12 (0%)