DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema3e

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001038549.1	Gene:	sema3e / 565658	ZFINID:	ZDB-GENE-030131-7864	Length:	768	Species:	Danio rerio

Alignment Length:	762	Identity:	207/762 - (27%)
Similarity:	353/762 - (46%)	Gaps:	129/762 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRPKLYV------ELGPEDVLKFVGNESVVDHFKLVTKDGNSL 107
            |  .|.|..|..|.:.:...:::.|:|.:      ||....|.: .|...:..:..|:.:....|
Zfish     6 W--TFTLCLVFWISSATQSTKSVYPRLRLSHKELWELNRTWVFQ-AGEGRLQQYTMLLDETQERL 67

  Fly   108 LIGARNTVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVCGT 171
            :||.::.:::|::..: ...:|:||:|.::..:.||::|:::..|.|||:::...:...|..|||
Zfish    68 IIGGKDVLYSLNLERITAPHKRIVWSSSQEQVEDCLMQGREKPECANYIKLVQHYNSTHLLACGT 132

  Fly   172 NSFRPMCNTYIIS-----DSNYTLEA--TKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSD 229
            .:|.|:|....:|     :..:.||:  .::|:...|:.|.....|.:...||:.|...|:..:|
Zfish   133 GAFSPVCAYIRVSRGAEQEREFRLESDHIESGRGRVPFHPNSPLASTVYRGELFVGLYTDYWEND 197

  Fly   230 PIIYR----EPLQTEQYDSLSLNAPNFVSSFT-------QGDFVYFFFRETAVEFINCGKAIYSR 283
            ..:||    ..::||..|...||.|.||.|..       ..|.||:||.|...:.....||:|:|
Zfish   198 AALYRLGNHSFIRTEVGDRQQLNEPKFVGSAVIPDNDDPADDKVYYFFTERVADVEGGNKAVYTR 262

  Fly   284 VARVCKWDKGGPHRFRNRWTSFLKSRLNCSI--PGDYPFYFNEIQSASNLVEGQYGSMSSKLIYG 346
            |||||..|:||.....|||:||||:||.||:  |.....:|:|::....|   :.....:..|:|
Zfish   263 VARVCANDQGGQRMLVNRWSSFLKTRLICSVAGPNGIDTHFDELEDVFVL---RKKDEKNPEIFG 324

  Fly   347 VFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------H 403
            :|:|.|....|.|||.:.:.||...|.|.|..:...:.:| .|.:.|||.||||||        .
Zfish   325 LFSTTSAVFKGYAVCMYNMDDIRAAFNGPFAHRERTDHHW-KVYDGKVPYPRPGSCASKINGGHF 388

  Fly   404 NDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVG 468
            :.|:...|..|.|.::|.||.:.|.....:|||:.|....:.||:||| :::...|. |:|:|:|
Zfish   389 SSSKEYSDEVLRFARSHPLMFQAVQPVHRRPILLDTEGGRKLTQLAVD-RVEAEDGH-YNVLFIG 451

  Fly   469 TDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIV 533
            ||:..::|.:...:.: ||.|..|::||:.|.....||..:.|....|            :|.:.
Zfish   452 TDNSVVLKMITIYNKE-ADTVEEVLLEELQVFKVPVPITEILISTKRQ------------QLYVG 503

  Fly   534 TDSQVVAIQLHRC--HNDKITSCSECVALQDPYCAWDKIAGKC-RSHGAPRWLEENYFYQNVATG 595
            ::..|..|::|:|  :.   ::|::|...:|||||||...  | |.:.|..:.:..:..|:|..|
Zfish   504 SELGVTQIRVHQCGLYG---SACADCCLARDPYCAWDGFT--CSRYYPAGLYTKRRFRRQDVRHG 563

  Fly   596 QHAACPSGKINSKDANAGEQ--KGFRNDMDLLDSRRQS------------KDQEIIDNIDKNFEG 646
            ......:|...|::.:..|:  .|..|:..||:.|.:|            .|.|.:.:.|:..:.
Zfish   564 NAVQQCNGLQLSEEQSISEKLVYGVENNSTLLECRPRSLQASVTWYIEHGLDMEEVKSDDRMIQT 628

  Fly   647 P---------QISADIINAQYT----VETLVMAVL----AGSIFSLLVGFFTGYFCGRRCHK--D 692
            |         :..|.:...|.|    ::||:...|    .|.:.:||             ||  :
Zfish   629 PHGLLLLRIMKSDAGVYVCQSTEHGFIQTLLRVTLEVLEEGKVEALL-------------HKPEE 680

  Fly   693 EDDNLPY-----------PDTE----YEYFEQRQNVNSFPSSCRIQQ 724
            ||.:||:           |.|.    |:.|.|....::|.   |::|
Zfish   681 EDSDLPHRAAPPCSFPSLPSTSSKLWYKDFMQLIGYSNFQ---RVEQ 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	144/483 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/36 (33%)
sema3e	NP_001038549.1	Sema_3E	46..516	CDD:200514	145/489 (30%)
		PSI	515..563	CDD:214655	15/52 (29%)
		Ig_Semaphorin_classIII	580..668	CDD:143279	17/87 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910