DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema4ga

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_001921423.3	Gene:	sema4ga / 563785	ZFINID:	ZDB-GENE-060503-381	Length:	863	Species:	Danio rerio

Alignment Length:	939	Identity:	246/939 - (26%)
Similarity:	388/939 - (41%)	Gaps:	223/939 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 IMKHKLSKFYGYGWMQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVG----------- 89
            :|.|:       .|: :||||..:|   .|.|....:|.|.:::.|...:.|.|
Zfish     4 MMNHR-------AWL-LFLLLLYVV---SSVWGYPFKPPLDLDVTPRTTVLFKGLLGCRRFRGLT 57

  Fly    90 -NESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQ--QRLVWTSPEDDTKMCLVKGKDEEA- 150
             |.|::    |:.:|.:.|.:|||..:|.|...|:...  |.:.|.:.:|..:.|..||||.:.
Zfish    58 LNYSLL----LLEEDADLLYVGARGALFALQASDVSSSLAQTIDWEASDDQMQQCWNKGKDNQTE 118

  Fly   151 CQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADN 215
            |.|:||.:...:...|:.|||::|.|:| .||...........:.|:..|||||....|.:|.|.
Zfish   119 CFNHIRFLQRFNSTHLYTCGTHAFSPLC-AYIDGREFKISSVFEEGREKCPYDPSKGYTGLLIDQ 182

  Fly   216 ELYSGTVADFSGSDPIIYREP---LQTEQYDSLSLNAPNFV----------SSFTQGDFVYFFFR 267
            ::|:.:..:|.....|....|   |:||:..:..|...:||          ||....|.:||||.
Zfish   183 QMYTASQYEFRSFPDIRRNSPNPILKTEEAPTQWLQEADFVGSALVRESLSSSAGDDDKIYFFFT 247

  Fly   268 ETAVE---FINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSAS 329
            |.:.|   :.:..:.  :|||||||.|:||....:.:||||||:||.||:| ||.|:||.::|..
Zfish   248 EKSQELSPYFSHSRV--ARVARVCKRDRGGLLTLQKKWTSFLKARLVCSLP-DYEFHFNVLRSVF 309

  Fly   330 NLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKE-QTGINSNWLPVNNAK 393
             .:||  .|......||:|.....::..||:|.:::.||...|:|.:.| :...||.|... ..|
Zfish   310 -FLEG--SSSQDSAFYGIFGLEWKNVKASAICQYSVSDIQWAFDGPYMESKEDSNSKWTQY-TGK 370

  Fly   394 VPDPRPGSC----H-----NDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIA 449
            ||:||||||    |     |.|..|||..|:|::.|.||...:.....:|:|.|.:..|  |:||
Zfish   371 VPEPRPGSCITDQHRAKGINSSINLPDDVLHFVRRHPLMYRQILPQGQRPLLFRRNVDY--TKIA 433

  Fly   450 VDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRT 514
            |.. :....|:.|.::|:|||.|.:.::|..|     |.:.  :|||:.:..:.:|:.::.|.:.
Zfish   434 VHT-VTGLDGQIYHILFIGTDEGWLQRAVKVE-----DHLH--IIEELQLFEEPQPVDSIVISKK 490

  Fly   515 MQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC---RS 576
            ..            .:.:.:.:.||.:.|..|  .:.:||.:||..:||:||||.:  :|   .|
Zfish   491 QM------------SVYVGSPTSVVQLPLSTC--TRYSSCFDCVMARDPFCAWDGL--ECVDITS 539

  Fly   577 HGAPRWLEENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNID 641
            |.:...|.     |::..|               |.|..|...:|..|..||......:::...
Zfish   540 HNSRANLT-----QDIQNG---------------NQGCDKSTADDQVLHRSRSVMAGDDVLLQC- 583

  Fly   642 KNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNL------PYP 700
                  ::|:::...::|:..   ..|.|  :.|..||..|           .|.|      ||.
Zfish   584 ------ELSSNLATPEWTLNG---NELKG--YGLDSGFRVG-----------TDGLLVIEAQPYQ 626

  Fly   701 DTEYEYF--EQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPP 763
            ..:|..|  |....|.....|..::||                 ||.|||. |...|:.|..
Zfish   627 SGDYCCFAIENSVRVPVLIYSLTVRQE-----------------LPVPPPV-KPTQPRFTTE--- 670

  Fly   764 MHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNY------------------- 809
            ::...|...|::...|.|    |..|  .|..|.::|:.:.|   |
Zfish   671 IYWTSQSSQSDSEEDFDP----TPMS--PRFEFLSVRNMEAM---YLSLITILGGLCFVLTVVLL 726

  Fly   810 --------RRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQP 866
                    |||.  .:.|:.||...|...:.               ::.|.:..........|..
Zfish   727 YVGFCLQGRRGK--YSLRAEKKRGGNMELKT---------------ISSHCNGKSDAHDGLLQIV 774

  Fly   867 HSSSGSSPVMSNSSSSPAPPSSSPSPQES 895
            ...:.:||   .....||||  .|.|.||
Zfish   775 PGEASTSP---TKDLPPAPP--LPPPPES 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	149/483 (31%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/36 (39%)
sema4ga	XP_001921423.3	Sema_4G	51..508	CDD:200523	149/490 (30%)
		PSI	510..549	CDD:214655	15/47 (32%)
		Ig	568..650	CDD:299845	19/104 (18%)
		IG_like	569..638	CDD:214653	17/91 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910