DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and si:ch211-129c21.1

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005170527.1	Gene:	si:ch211-129c21.1 / 563087	ZFINID:	ZDB-GENE-030131-5796	Length:	791	Species:	Danio rerio

Alignment Length:	533	Identity:	170/533 - (31%)
Similarity:	271/533 - (50%)	Gaps:	63/533 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LVTKDGNSLLIGARNTVFNLSIHDL-VEQQRLVWTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVP 161
            |:.:|...|::|||..||.|.|:|: |.:.:::|...|:..|.|..|||..:. |.||||::...
Zfish    54 LIREDLGLLVLGAREAVFALDINDISVSRSKVLWKVTEEKQKECTSKGKHPDIDCHNYIRMLHQM 118

  Fly   162 SPGRLFVCGTNSFRPMCNTYIISDSNYTLEA-TKNGQAVCPYDPRHNSTSVLADNELYSGTVADF 225
            :...:::||||:|.|.|:.....:....||. .::|:..||:||...|:||:.|.:|||.|..:|
Zfish   119 NDSVMYICGTNAFSPTCDYITYDNGQLQLEGKQEDGRGKCPFDPFQRSSSVMVDQDLYSATSLNF 183

  Fly   226 SGSDPIIYR-EPLQTEQ-YDSLSLNAPNFV----------SSFTQGDFVYFFFRETAVEFINCGK 278
            .||:|:|.| .|:.... ..|..||.|||:          |.....|.:|.||.|.|:|:....|
Zfish   184 LGSEPVILRTSPITLRTLLKSSWLNEPNFIYMDAVPESEDSPEGDDDKIYMFFSENAIEYDFYNK 248

  Fly   279 AIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIP-GDYPFYFNEIQSASNLVEGQYGSMSSK 342
            .:.||||||||.|.||....:.:||||||:||:||:| ...|:...::      ...::......
Zfish   249 LVVSRVARVCKGDMGGLRTLQRKWTSFLKARLDCSVPEPSLPYVIQDV------FHVRHQKWRKS 307

  Fly   343 LIYGVFNTPSNSI-PGSAVCAFALQDIADTF-EGQFKEQTGINSN---WLPVNNAKVPDPRPGSC 402
            :.|.:|.:.|:|. ..|||||:.:.||::.| .|:||.:..:..:   |: ..:..:|.||||.|
Zfish   308 VFYAIFTSQSSSTDQSSAVCAYNVTDISNVFSRGKFKTEVAVEMSDVKWV-TYSGDLPVPRPGDC 371

  Fly   403 HND---------SRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG 458
            .|:         |..:||.||.||:...|||:.|.....:|:|::...:  .|::.|| .:....
Zfish   372 INNAARTSGIKSSMNIPDKTLQFIRDRPLMDDAVHPITGKPLLLKRGPL--LTRLVVD-MVTAAD 433

  Fly   459 GKTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDG 523
            |::|.::||||.:|.:.|:||.:.       ...:|||:.:....|.|   :::|..|
Zfish   434 GQSYPMMFVGTANGYVQKAVNYDG-------EMHIIEEVKLFESEEAI---DVLRLHQ------- 481

  Fly   524 SYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYF 588
                .:|...:.|.||.:.:..|  .:.:||.:||..:|||||||..|.:|....|.....::..
Zfish   482 ----NQLYAGSASGVVQMPVSNC--SRYSSCLDCVLARDPYCAWDVPAQRCSRFPASTEHAKSNL 540

  Fly   589 YQNVATGQHAACP 601
            .|::..|....||
Zfish   541 IQSLKDGDATQCP 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	151/476 (32%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/33 (42%)
si:ch211-129c21.1	XP_005170527.1	Sema_4E	42..498	CDD:200521	151/474 (32%)
		PSI	499..553	CDD:214655	17/55 (31%)
		Ig_Sema4D_like	558..644	CDD:143281
		IG_like	560..623	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010