DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema4c

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001121718.1	Gene:	sema4c / 561895	ZFINID:	ZDB-GENE-080303-16	Length:	863	Species:	Danio rerio

Alignment Length:	917	Identity:	241/917 - (26%)
Similarity:	375/917 - (40%)	Gaps:	212/917 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLV----------TKDGNSLL 108
            :||.:.|||.:.....|..|.      |...:|:......:..|:.|          .:....|.
Zfish     6 VLLVIFVIGFEKGICVNWNPV------PRKTVKYNDVHDSMARFRAVGVWNYTMLTLAEHERVLY 64

  Fly   109 IGARNTVFNLSIHDLVEQQR--LVWTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCG 170
            :|||..:|.|..:|:..|.|  :.|::|.:..|.|..|||:.:. |.||||.:...:...|:.||
Zfish    65 VGARENIFALDPNDISRQLRPQIEWSAPAEKKKECAAKGKNNQTECFNYIRFLQSYNHTHLYTCG 129

  Fly   171 TNSFRPMCNTYIISDSNYTLE--ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIY 233
            |.:|:|.| |||.:| ::||:  |.::|:..|||||....|.::.|.||||.|:.:|.|::|:|.
Zfish   130 TYAFQPKC-TYINAD-HFTLDSAALEDGKGKCPYDPAKGHTGLIVDKELYSATLNNFLGTEPVIL 192

  Fly   234 REPLQTEQYDSLS------LNAPNFVSSFT----------QGDFVYFFFRETAVEFINCGKAI-Y 281
            |. |..:.|...|      ||.||||.|..          ..|.:||||.|.||| ::|...: .
Zfish   193 RN-LGQQHYSMKSEYLPAWLNEPNFVGSALVRESRNSKDGDDDKIYFFFSERAVE-LDCDSDLTV 255

  Fly   282 SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYG 346
            :|||||||.|.||....:.:||:|.|:||.||.| :....||.:::...|....:.:.|   .||
Zfish   256 ARVARVCKGDLGGTRTLQKKWTTFQKARLMCSFP-ERHITFNNLRAVFTLPGADWRTTS---FYG 316

  Fly   347 VFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------- 402
            :|:.....:..||||.:.:.::.:.|:|.:||....:..|...... ||.||||:|
Zfish   317 IFHAQWGDVDVSAVCQYQIGEVKNVFDGPYKEYRESSQRWGRYTGT-VPSPRPGACITNFDRENG 380

  Fly   403 HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFV 467
            :|.|..|||.||||.|.|.||:....|   :|:|: |..| .||::||| ::.:...::|:::|:
Zfish   381 YNSSLQLPDATLNFAKKHPLMELRAEA---RPLLL-TKGI-NFTRLAVD-RVSSLDQRSYNMLFI 439

  Fly   468 GTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLII 532
            ||..|.:.:.|...|       .:.|||||.:..:.:|:.:|.|..:.:|            |.|
Zfish   440 GTADGWLQRVVILGS-------EAHVIEEIQLFDRQQPVDSLTISHSKKY------------LYI 485

  Fly   533 VTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKC----RSHGAPRWLEENYFYQNVA 593
            .:.|:|:.:.|..|  .:..|..:|:..:|||||||.....|    ...|:...|.::...:...
Zfish   486 GSRSEVLQLPLANC--SRYHSQPDCLLSRDPYCAWDSEGRACVRIDLHRGSTSTLSQDLMLERFN 548

  Fly   594 TGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGP----------Q 648
            .|:........|.|.|     ....||...::.|     |..:..|:..|...|          .
Zfish   549 RGKAKFDKPFSIPSPD-----HSRLRNVTVVVGS-----DLVLPCNLVSNLAQPFWELNERELAL 603

  Fly   649 ISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYE-------- 705
            :..:.|..::  :..:.|::.....||..|.:..|        .|:..:.:....|:
Zfish   604 VEGEAIGPRF--DRALRALVIPQAGSLQAGRYICY--------SEEQGVKFQTERYQVAVVASAP 658

  Fly   706 -YFEQRQNVNSFP------------------SSCRIQQEPKLL------PQVEEVTYAEPVLLPQ 745
             :.|.|....|..                  :|..:::..||.      .:..|.|...|:.||:
Zfish   659 VFMEARAPDGSMGLFWVLVITLGAACLLLLIASLYLRRRLKLALGKGAEMKPLESTLVYPITLPK 723

  Fly   746 PPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYR 810
            .||......|...            .|.|..|      :.|                   |.||.
Zfish   724 EPPSRPSFVPSRM------------ANDEDRF------WET-------------------GANYY 751

  Fly   811 RGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPV 875
            ..||     |:|..                  |.|.:.|...|.||  .....|..||.||.|..
Zfish   752 CSDG-----SLKIV------------------PGHAMCTTGSSASP--SAIPGQPIHSPSGLSLT 791

  Fly   876 MSNSSSS 882
            ...:||:
Zfish   792 NIRNSST 798

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	161/495 (33%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/37 (30%)
sema4c	NP_001121718.1	Sema_4C	40..497	CDD:200519	160/490 (33%)
		PSI	498..541	CDD:279745	13/44 (30%)
		Ig	569..656	CDD:299845	15/101 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910