DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and si:ch211-113g11.6

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005158115.1	Gene:	si:ch211-113g11.6 / 559008	ZFINID:	ZDB-GENE-060503-473	Length:	632	Species:	Danio rerio

Alignment Length:	740	Identity:	176/740 - (23%)
Similarity:	291/740 - (39%)	Gaps:	223/740 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLV----------TKDG 104
            |.:.:|.|:..:             :..|..|.  |||:.|||  ..|:.:          .::.
Zfish     1 MNLLVLATLFSV-------------VLAEKSPR--LKFIVNES--PRFRFIKPENFTTVYHQQET 48

  Fly   105 NSLLIGARNTVFNLS-----IHDLVEQQRLVWTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSP 163
            :.|.:|.:..::.||     :||:    ::.....|:..::|..|... :..|.|:  |.|:...
Zfish    49 DVLYVGGQGVIYKLSFRDKEVHDI----QIPVVMDENAKELCHSKSSQWKHECDNF--ITVIEKV 107

  Fly   164 G-RLFVCGTNSFRPMCNTYIISDSNYT--LEATKNGQAVCPYDPRHNSTSVLADNELYS------ 219
            | .:.||||.:..|.| ..:::||..|  .|.|.....:.|: |...|.|:.||..|||
Zfish   108 GDSMVVCGTRAGTPKC-WLLVNDSTLTDMSEETAASNILAPF-PSQRSISLSADENLYSALSAAA 170

  Fly   220 ---GTVADFSGSDPIIYREPLQTEQYDSLSLNAPNFVSSFT------QGDFVYFFFRETAVEFIN 275
               ||:....||     ::.|:||   :..|..|.|..:..      ..:.:||||.|     :|
Zfish   171 GQTGTIRRTFGS-----KKQLKTE---NKWLQNPQFAGAAVIPHEEKLKNEIYFFFSE-----VN 222

  Fly   276 CGKAI-----YSRVARVCKWDKGG-PHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEG 334
            ...::     .:|:.|||..|:|| .:...|.||:|||:|:.|...|. |..:|..:.|..|.
Zfish   223 SSSSLDEEPYRARIGRVCMVDEGGLQNVLPNSWTTFLKARVMCGKSGT-PVQYNNFKQAFVLT-- 284

  Fly   335 QYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRP 399
              ..:.:.||||:|   ||:...:.|||::::||...|          :|:.|...|:.:.:|||
Zfish   285 --SHLRTGLIYGIF---SNAWNTTVVCAYSIEDIDKAF----------SSSKLKGYNSPLANPRP 334

  Fly   400 GSC--HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTY 462
            |:|  .|:::|.....|:.|:.|..::|.:......|:  ..|....||.|..|. :.....:.|
Zfish   335 GTCAFKNNTQAHNQKILSVIRDHPEIEEVIGPVHDVPL--ELSVQDHFTHIVADT-VLAVNDEHY 396

  Fly   463 DVIFVGTDHGKIIKSVNA-ESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYD 526
            .:|::||:.||::|.::. |.|        .:|.:..:.....|:.|:.|       .||
Zfish   397 SIIYLGTEKGKVLKVLHTIEGA--------FIIAQYSLFHDDSPVTNMAI-------DPK----- 441

  Fly   527 DGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQN 591
            .|.|.|.|..:|..:.|..|....: ||.||:..:|||||||....||
Zfish   442 KGHLYIGTQLEVQRLPLADCGRYGL-SCRECILSRDPYCAWDVHKKKC----------------- 488

  Fly   592 VATGQHAACPSGKINS-------KDANA---GEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEG 646
                  .|..:|.||:       ..:||   |:.|.        ...|.:..:|::  :||  :|
Zfish   489 ------TAITTGSINTGSLIQTLDHSNASICGDAKA--------PKARSTIPKEVL--VDK--DG 535

  Fly   647 PQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEY--EYFEQ 709
            |.:                                               ||.|...|  .|..:
Zfish   536 PVL-----------------------------------------------LPCPVRSYHASYRWE 553

  Fly   710 RQN-VNSFP-----SSCRIQQEPKL 728
            :.| :.::|     |||.:...|:|
Zfish   554 KDNCIKTYPCTISGSSCVLAPTPEL 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	127/497 (26%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	14/33 (42%)
si:ch211-113g11.6	XP_005158115.1	Sema	37..459	CDD:301699	123/483 (25%)
		PSI	460..>490	CDD:214655	14/53 (26%)
		Ig	527..604	CDD:299845	17/103 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100