DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and si:dkey-49n23.1

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_021329223.1	Gene:	si:dkey-49n23.1 / 558742	ZFINID:	ZDB-GENE-050208-762	Length:	758	Species:	Danio rerio

Alignment Length:	872	Identity:	242/872 - (27%)
Similarity:	377/872 - (43%)	Gaps:	209/872 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 WMQVFLLLTVLVIGNQSAWQENIRPKL---YVELGPED--VLKFVGNESVVDHFKLVTKDGNSLL 108
            |......|.||.:.:.:|..:| .|:|   :.||...:  .:.:.|.|.......|:.:|...||
Zfish     7 WRTGLFSLLVLSLLHCNAGNQN-TPRLQLTHTELRSRNGSAVFWDGGEGGAYQALLLDEDRGWLL 70

  Fly   109 IGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKD-EEACQNYIRIMVVPSPGRLFVCGT 171
            :|.|:.::.|:...|.:..|.: |.:.::..:.|...||: ...|.||:|::...:...::||||
Zfish    71 VGGRDHIYMLNSDSLTQPSRKIHWPAGQEHIERCKYAGKNLSMDCANYVRLLQPFNKTHVYVCGT 135

  Fly   172 NSFRPMCNTYIISDSNYTLE---------ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSG 227
            .:|.|.| |||  |..:.||         ..::|:..||:.|:...|:.|.|.|||:||..||.|
Zfish   136 GAFHPQC-TYI--DLGHNLEKPTFQLLSHVGESGRGKCPFSPQEPFTAHLTDGELYAGTAVDFMG 197

  Fly   228 SDPIIYREP--------LQTEQYDSLSLNAPNFVSSFT-------QGDFVYFFFRETAVEFINCG 277
            ::..|:|..        ::||.|....||.|.||.|::       ..|.|||||:|||||.....
Zfish   198 TNAAIFRTSVHSNNQHYIRTEAYQDHWLNEPEFVGSYSIPDTHSLDDDKVYFFFKETAVESNQLD 262

  Fly   278 KAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSI--PGDYPFYFNEIQSASNLVEGQYGSMS 340
            |.||||||||||.|.||.....|||::|||:||.|::  ||....:|:|::... |:|.:  ...
Zfish   263 KRIYSRVARVCKNDIGGKRSLINRWSTFLKARLVCTVPGPGGMDTHFDELEDIF-LLETK--DPQ 324

  Fly   341 SKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--- 402
            :.:|||||:|.|:...|||||.:::..|...|.|.|..:...:..|:.. ..|:|.||||:|
Zfish   325 NPVIYGVFSTSSSVFRGSAVCVYSMASIRAAFNGPFAHKESPDYRWMEY-KGKIPYPRPGTCPSE 388

  Fly   403 -----HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTY 462
                 :..:|..||..::|::.|.||.|.|.....:|:..|.:|.||..::.|| ::....|: |
Zfish   389 TYDALYKSTRDFPDDVVSFMRAHQLMWEPVVPIHRRPVFTRINTPYRLKKLVVD-RVDAEDGQ-Y 451

  Fly   463 DVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDD 527
            ||:.:|||.|:::|.|:....:.  ::..:::||::|.....||.::|:....|.
Zfish   452 DVLHLGTDDGRVLKVVSVPKENW--EIEEIILEELNVFKTQTPILSMELSTKRQV---------- 504

  Fly   528 GKLIIVTDSQVVAIQLHRCH-NDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQN 591
              |.|.:|..||.:.:.||. ..|  :|.:|...:|||||||  ...|          .|||
Zfish   505 --LFISSDENVVQLPVQRCELYGK--ACVDCCLARDPYCAWD--GSSC----------TNYF--- 550

  Fly   592 VATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINA 656
                     ||.|          ::..|.|:...|...|.:|..         :|.:      ||
Zfish   551 ---------PSNK----------RRARRQDVRYGDPWSQCQDMR---------DGSE------NA 581

  Fly   657 Q----YTVETLVMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFP 717
            :    |.|||       .|.|...|                 .|.|....:: .|:...:.||
Zfish   582 ELKTVYGVET-------NSTFLECV-----------------SNSPQATIKW-IFQPNHSQNS-- 619

  Fly   718 SSCRIQQEPKLLPQVEEVTYAE-PVLLPQPPPPNK--------MHSPKNTLRKPPMH-----QMH 768
                    .:|:|..|.:.:.: .:||.|....|.        .||...||.:..:|     ||.
Zfish   620 --------KELVPGEENLLHMQRGLLLQQITSTNAGLYLCMAFEHSFSRTLARYELHVIPQNQMS 676

  Fly   769 QGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQ---VMG------DNY--------RRGDGFS 816
            :..|:      .|..:.|           :|||::   :||      |.|        :|.....
Zfish   677 RAQNN------LPGNHAT-----------SLRSYKELHLMGVGGLTADEYCEHLWYREKRRQHKH 724

  Fly   817 TTRSVKKAVNNTNTRNRSLGRARRQPP 843
            .|...|:...|...|.|     |:.||
Zfish   725 RTLKWKQVSENRKARVR-----RQNPP 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	159/490 (32%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/34 (38%)
si:dkey-49n23.1	XP_021329223.1	Sema_3	48..521	CDD:200500	160/495 (32%)
		PSI	520..557	CDD:214655	19/72 (26%)
		Ig_Semaphorin_classIII	581..672	CDD:143279	25/125 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020