DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema6e

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001186294.1	Gene:	sema6e / 556743	ZFINID:	ZDB-GENE-040724-119	Length:	1064	Species:	Danio rerio

Alignment Length:	1096	Identity:	324/1096 - (29%)
Similarity:	472/1096 - (43%)	Gaps:	227/1096 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 FVGNESVVD------HFKLVTKDGNSLLIGARNTVF--NL--SIHDLVEQQRLVWTSPEDDTKMC 141
            |.||.|..|      .|:.:.:..:.:.|.||:.||  ||  |:..:|.||:|.|.:  .|.:.|
Zfish    54 FQGNMSDNDTARLGLDFQRMLRINHMVYIAARDHVFAINLSASLERIVPQQKLTWKT--KDVEKC 116

  Fly   142 LVKGKDEEACQNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKN---GQAVCPYD 203
            .|:||:.:.|.|||:::|..:...||.||||:|.|.|..|.:|    :||....   |||.||::
Zfish   117 TVRGKNSDECYNYIKVLVPRNDETLFACGTNAFNPTCRNYKMS----SLEQDGEEVIGQARCPFE 177

  Fly   204 PRHNSTSVLADNELYSGTVADFSGSDPIIYRE------PLQTEQYDSLSLNAPNFVSSFTQGDFV 262
            .|.::..:.|..:.||.|:.||..||.:|||.      .|:|.:|||..|..|:|:.:...|::|
Zfish   178 SRQSNVGLFAGGDFYSATMTDFLASDAVIYRSLGESSPVLRTVKYDSKWLREPHFLHAIEYGNYV 242

  Fly   263 YFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNR-WTSFLKSRLNCSIPGDYPFYFNEIQ 326
            |||..|.|||:...||.::||||||||.|.||..|...| ||||||:|||||:|||..|||:.:|
Zfish   243 YFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSPRVLERYWTSFLKARLNCSVPGDSFFYFDVLQ 307

  Fly   327 SASNLVEGQYGSMSSKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNN 391
            |.:|:::..:    ...:.|||.|.:|||.|||||||.:.||...|.|:||||....|.|.||.:
Zfish   308 SLTNVMQINH----RPAVLGVFTTQANSITGSAVCAFYMDDIEKVFNGKFKEQRNSESAWTPVPD 368

  Fly   392 AKVPDPRPGSCHNDSRA--------LPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQI 448
            ..||.||||||..|..|        .||.||.|||::.||||.||:..::|...||::.::.|||
Zfish   369 EAVPKPRPGSCAGDGPAAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFKLTQI 433

  Fly   449 AVDAQIKTPGG--KTYDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEI 511
            |||    |..|  |.|.|:|:|:::|.::|.:.:...:|:  .::.|:|:|||...::.....|.
Zfish   434 AVD----TAAGPYKNYTVVFLGSENGHVLKVLASMHPNSS--YSTQVLEDIDVYNPNKCNVRGED 492

  Fly   512 VRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRS 576
            .|.:..:..|    |...|.:.....|:.:.|.||.:..|...| |::.:||||.| ..||.|.:
Zfish   493 RRILGLELDK----DHHALFVAFTGCVIRVPLSRCSDYGICRKS-CLSSRDPYCIW-LSAGNCAT 551

  Fly   577 ------HGAPRWLEENY------FYQNVAT--GQHAACPS--GKINSKDA---NAGEQKGFRNDM 622
                  .|..:::|..|      .:..:||  .|:.|..|  ||.:...|   |.|.........
Zfish   552 VAPGFKSGFEQYVESGYPQYPDSCHDVLATTRKQNPAVDSAYGKTSPTSASTTNQGPAGAPETGT 616

  Fly   623 DLLDSRRQSKDQEIIDNIDKNFEG----PQISADIINAQYTVETLVMAVLAGSIF-SLLVGFFTG 682
            ...:.||..:....::......||    |::.....:..||:  |:..||...:. :.|.||...
Zfish   617 HPEEGRRGGQGSPDLEPGSVEMEGVRRPPEVDKSNHSVHYTL--LIACVLVAFVLGAFLSGFLVS 679

  Fly   683 YFCGRRCHK----DEDDNLPYPDT-------------EYEYFEQRQNV------NSFPSSCRIQQ 724
            .:|....:|    .:|...|.|..             |.:..:::..|      |||.::.:.|.
Zfish   680 CYCNHNVNKTKRLSKDPEAPIPHALSLRSLAKLNGLLESQNKDEKLEVSSPKLYNSFFANGKEQA 744

  Fly   725 EPKLL--PQVEEVTY------AEPVLLPQPP-----PPNKMHSPK---------NTLRKPPMHQM 767
            ..:..  ..:.|:.:      ||...||.|.     |...|.:.|         |..::|..|.|
Zfish   745 HRRNAHHAAMTELIHPHHHHSAELSGLPTPDSTPELPIKSMKAFKNQWEKNQNCNNAKEPKSHNM 809

  Fly   768 HQG-PNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRRGDGFSTTRSVKKAVNNTNTR 831
            ... |.|....|..|..:.             |.:.||:|.:....:         :.|:||.
Zfish   810 GASRPTSAMQHQMFPFSHG-------------LTNGQVLGGSVHMDE---------RKVHNTE-- 850

  Fly   832 NRSLGRARRQPPR---HGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSS----------- 882
                 |...||..   |.||.   ..|..:..:...:.:.::|.||.:..||.|
Zfish   851 -----RVVSQPYHCYPHKIVD---VTSLDELLKHIHEINVATGKSPSVLTSSMSANAGQMAFANR 907

  Fly   883 --PAPPSSSPSPQESPKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQS-------HP---H-- 933
              |..|.:..:|..|   .|.:.|| |   |:.|.:    .....||.||       ||   |
Zfish   908 VQPHIPETESAPYYS---SSTLPRDSL---TRRMDI----PPEIPPHHQSTLERVSRHPAQRHSL 962

  Fly   934 ---PLPPPGPTTP---------PAQPRARSPMIGRTYAKSMPVT-PVQPQSPLAETPSY-ELYER 984
               |..|.|...|         ..||...|.|..........|. |:.|...|....|| |..|.
Zfish   963 ITTPKMPSGGVVPRQHSFNQRSSHQPLLLSRMNSNGSNSGCDVRHPLIPNGYLTRQHSYSEQPEV 1027

  Fly   985 HSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPPYDTPHLIASPPLPPPRRFRF 1040
            |..|..                ..|:||....||.|...|   ||.|:....:|.:
Zfish  1028 HRGAIV----------------RRTASLKPDVPPKPLFIP---ASSPVNQAGKFNY 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	188/484 (39%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/39 (33%)
sema6e	NP_001186294.1	Sema_6	60..521	CDD:200503	186/480 (39%)
sema6e	NP_001186294.1	PSI	522..>548	CDD:307546	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1228
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm6502
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.820