DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema1a and sema5ba

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_684379.3	Gene:	sema5ba / 556471	ZFINID:	ZDB-GENE-070912-187	Length:	1101	Species:	Danio rerio

Alignment Length:	948	Identity:	261/948 - (27%)
Similarity:	393/948 - (41%)	Gaps:	265/948 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGRLFVC 169
            |.|::||||.:|.|::.::...|...|...||..:.|..|||.|..||||||:::| :...:..|
Zfish    90 NELIVGARNYLFRLNLSNISLIQATEWGPDEDTRRSCQSKGKTELECQNYIRVLLV-NKTEVVTC 153

  Fly   170 GTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADN-ELYSGTVADFSGSDPIIY 233
            |||:|:|:|.|....:.:..||.. ||.|.||||||||||:|:.:: |||:.||.||||.||:||
Zfish   154 GTNAFQPLCITREAGNMSRVLERV-NGVARCPYDPRHNSTAVVTESGELYAATVIDFSGRDPVIY 217

  Fly   234 RE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKG 293
            |.     ||:|.||:|..||.|:|:|::..|.|.:||.||.|||. :|||.:|||||||||.|.|
Zfish   218 RSLGGMPPLRTAQYNSKWLNEPHFISAYDVGLFTFFFLRENAVEH-DCGKTVYSRVARVCKNDIG 281

  Fly   294 GPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSNSIPGS 358
            |.....:.||:|.|:|||||..|:.|||:||:||...|.|       ..||||:|.|..|||..|
Zfish   282 GRFLLEDTWTTFTKARLNCSRSGEIPFYYNELQSTFYLPE-------QDLIYGIFTTNVNSIAAS 339

  Fly   359 AVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHND-------SRALPDPTLNF 416
            ||||:.|..|...|.|.|:.|....|.|||..| .:|:.:.|:...:       .|:|.|....|
Zfish   340 AVCAYNLSAITQAFNGPFRSQENPRSTWLPTPN-PIPNFQCGTIDEEGPNERLTERSLQDAQRLF 403

  Fly   417 IKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAE 481
                 ||::.|......|::.:...  ||:::.||  |.......:.|:::||::|.|:|::
Zfish   404 -----LMNDVVQPVSVDPLVWQDDV--RFSKLVVD--IVQGQDSLHHVMYIGTEYGTILKAL--- 456

  Fly   482 SADSADKVTSVVIEEIDVLTK--SEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLH 544
             |.:...:....:||:.:...  .:||.:|:|:            :.|..|.:..:.:|:.|.|.
Zfish   457 -ATTNKSLQGCYLEEMQLFPPGLQQPILSLQIL------------HGDRTLFVGLNDKVLKIPLA 508

  Fly   545 RCHNDKITSCSECVALQDPYCAWDKIAGKCR----SHGAPRWLEENYFYQNVATGQHAACPSGKI 605
            ||.:.|....  |:..:||||.||:...:|.    |....:|      :||:     .|||. :.
Zfish   509 RCSSYKTELM--CLDARDPYCGWDRKQRRCTTIEDSSNMSQW------FQNI-----TACPL-RN 559

  Fly   606 NSKDANAG---------EQKGFRNDMDLLDSRRQSKDQEIIDNI------DKNFEGPQISADIIN 655
            .:.|...|         ...|......|..||        :.|.      .||.:||.|  ::.|
Zfish   560 QTTDGAYGPWAPWQPCSHDDGEGTSTCLCRSR--------VCNSPPPRCGGKNCQGPTI--EVSN 614

  Fly   656 AQYTVETLVMAVLAGSIFSLLVGFFTGYF----CGRRCH-----KDEDDNLPYP----------D 701
            ....                  |.:|.:.    |...|.     :....|.|.|          .
Zfish   615 CSRN------------------GGWTPWSSWGQCSTSCEIGFEVRQRSCNNPSPRHGGRVCVGQS 661

  Fly   702 TEYEYFEQR---------------------------------QNVNSFP------SSCRIQQEPK 727
            .|..:..::                                 :|.||.|      .:|.::..|:
Zfish   662 REQRFCNEKVSCPQPIFWSSWSPWSKCSADCGGGVHSRSRNCENGNSCPGCALEYQACNLESCPE 726

  Fly   728 L---------LP---------QVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKPPMHQMHQGPNS- 773
            :         :|         |.:.|.|.....|..|                  |::..|...
Zfish   727 VRRNTPWTPWMPVNITQGGARQEQRVRYICRAQLADP------------------HELQLGKRKV 773

  Fly   774 ETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYR------RGDGFST--------------T 818
            ||  :|.|:           |...|..:..::.:..|      .|.|:|:              .
Zfish   774 ET--RFCPN-----------DGMVTCETDSLVEELLRMPGVRLSGTGWSSWEMWSACTQECAKGY 825

  Fly   819 RSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSSSSP 883
            |:.|::..||:.:|              |.|..| .||.:.|..:.||....|:....|:.|...
Zfish   826 RTRKRSCTNTDGKN--------------IPTACR-GSPVEYQDCNPQPCPVKGAWSCWSSWSQCS 875

  Fly   884 AP----------PSSSPSPQESPKNCSYIYRDXLICNT 911
            .|          ..:||:|......|..::.:..:|||
Zfish   876 VPCGGGHYQRTRTCTSPAPANGGDICIGLHTEEALCNT 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	174/455 (38%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	12/37 (32%)
sema5ba	XP_684379.3	Sema	72..508	CDD:301699	173/453 (38%)
		PSI	509..556	CDD:279745	16/59 (27%)
		TSP1	567..618	CDD:214559	12/60 (20%)
		TSP1	621..674	CDD:214559	7/52 (13%)
		TSP1	679..725	CDD:214559	5/45 (11%)
		TSP1	808..860	CDD:214559	14/66 (21%)
		TSP1	871..917	CDD:214559	9/43 (21%)
		TSP1	920..960	CDD:214559
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810