DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and PLXNA3

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_059984.3	Gene:	PLXNA3 / 55558	HGNCID:	9101	Length:	1871	Species:	Homo sapiens

Alignment Length:	1061	Identity:	205/1061 - (19%)
Similarity:	346/1061 - (32%)	Gaps:	331/1061 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVDHFKLVTKDGNSLLIGARNTVFNL 118
            |||..|.:|.              .||......||..::.:.|..:....| .:.:||.|.||.|
Human     7 LLLLFLAVGG--------------ALGNRPFRAFVVTDTTLTHLAVHRVTG-EVFVGAVNRVFKL 56

  Fly   119 SIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEAC-------QNYIRIMVVP-SPGRLFVCGTNSFR 175
            : .:|.|.:..| |.|.:|...| ........|       .|..:::::. :..||..|| :.::
Human    57 A-PNLTELRAHV-TGPVEDNARC-YPPPSMRVCAHRLAPVDNINKLLLIDYAARRLVACG-SIWQ 117

  Fly   176 PMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLA------------------DNELYSGTV 222
            .:|....:.|      ..|.|      :|.|.....|:                  .::|:.||.
Human   118 GICQFLRLDD------LFKLG------EPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTA 170

  Fly   223 AD--------------FSGSD-----PIIYREPLQTEQY----DSLSLNAPNF----VSSFTQGD 260
            .|              .|..|     .::|::...:.|.    |:||| .|.|    :..|....
Human   171 VDGKSEYFPTLSSRKLISDEDSADMFSLVYQDEFVSSQIKIPSDTLSL-YPAFDIYYIYGFVSAS 234

  Fly   261 FVYFF---------FRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG 316
            ||||.         ..:||.|     |...|::.|:|..|        :.:.|:::..:.||..|
Human   235 FVYFLTLQLDTQQTLLDTAGE-----KFFTSKIVRMCAGD--------SEFYSYVEFPIGCSWRG 286

  Fly   317 DYPFYFNEIQSASNLVEGQYGSMS------SKLIYGVF--------NTPSNSIPGSAVCAFALQD 367
               ..:..:|||.....|...:.:      ..:::.:|        :.|..:|    :|.|.|.:
Human   287 ---VEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQTI----LCLFTLSN 344

  Fly   368 IADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDPTLNFIKTHSLMDENVPAF-- 430
            |                      ||.: ..|..||:.....|..|.        |:::.:|..
Human   345 I----------------------NAHI-RRRIQSCYRGEGTLALPW--------LLNKELPCINT 378

  Fly   431 ------------FSQPI----------LVRTST-------IYRFTQIAVDAQIKTPGGKTYDVIF 466
                        .:||:          |:..||       .|.:.|              :.|:|
Human   379 PMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYRQ--------------HSVVF 429

  Fly   467 VGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLI 531
            :||..|. :|.|..:....|.     :.|.:.|:..|..:|:|..            |.|...:.
Human   430 IGTRSGS-LKKVRVDGFQDAH-----LYETVPVVDGSPILRDLLF------------SPDHRHIY 476

  Fly   532 IVTDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHG------APRWLEENYFY- 589
            ::::.||..:.:..|  ::..||:.|:...||:|.|..:..:|...|      ||....|....
Human   477 LLSEKQVSQLPVETC--EQYQSCAACLGSGDPHCGWCVLRHRCCREGACLGASAPHGFAEELSKC 539

  Fly   590 -------QNVATGQHAACPSGKI-----NSKDANAGEQKGF----RNDMDLLDSRRQSKDQEIID 638
                   .||:    ...|..::     |..|.:||....|    .|:..||.|.........:.
Human   540 VQVRVRPNNVS----VTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSGELLCPSPSLQ 600

  Fly   639 NIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCG--RRCHKDEDDNLPYPD 701
            .:.....|.       .|..||...:::...|..|:  ...|..|.|.  :.|......  |||
Human   601 ELRALTRGH-------GATRTVRLQLLSKETGVRFA--GADFVFYNCSVLQSCMSCVGS--PYP- 653

  Fly   702 TEYEYFEQRQNVNSFPSSCRIQQE--------PKLLPQVE---EVTYAEPVL-----LPQPPPPN 750
              ..:.:.|....|.|..|..|:.        |::||..:   .|...:|:.     ||||....
Human   654 --CHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPSGDLLIPVGVMQPLTLRAKNLPQPQSGQ 716

  Fly   751 KMHS----PKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNYRR 811
            |.:.    .:...::.|..:.    ||.:: |.|    |...||.|.::..|.....|:.|
Human   717 KNYECVVRVQGRQQRVPAVRF----NSSSV-QCQ----NASYSYEGDEHGDTELDFSVVWD---- 768

  Fly   812 GDGFSTTR--SVKKAVNNTNTRNRSLGRARRQPPRHG---IVTQHRSNSPQQQQQQSQQPHSSSG 871
            || |...:  |.:..:.....:..|.|...:..||..   .:::||.      |.::..|...:.
Human   769 GD-FPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRC------QLRTHCPAPKTN 826

  Fly   872 SSPVMSNSSSSPAPPSSSPSPQESPK-----------NCSYIYRD------XLICNTKSMPLIQA 919
            ...:....:....|..:...|...||           |...:.|:      .:.||:.....|.|
Human   827 WMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREVGLRVAGVRCNSIPAEYISA 891

  Fly   920 QSTHAQPHPQSHPHPLPPPGP 940
            :....:  .:....|.|||||
Human   892 ERIVCE--MEESLVPSPPPGP 910

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	103/561 (18%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	10/39 (26%)
PLXNA3	NP_059984.3	Sema_plexin_A3	21..489	CDD:200534	105/568 (18%)
		PSI	490..>530	CDD:279745	11/41 (27%)
		PSI	637..684	CDD:214655	10/51 (20%)
		PSI	788..831	CDD:214655	8/48 (17%)
		IPT_plexin_repeat1	840..934	CDD:238585	16/73 (22%)
		IPT_plexin_repeat2	935..1021	CDD:238584
		IPT_plexin_repeat3	1023..1123	CDD:238586
		IPT_PCSR	1125..1208	CDD:238337
		Plexin_cytopl	1294..1841	CDD:285529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910