DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema6dl

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005173705.1	Gene:	sema6dl / 550377	ZFINID:	ZDB-GENE-050417-171	Length:	1070	Species:	Danio rerio

Alignment Length:	1142	Identity:	329/1142 - (28%)
Similarity:	497/1142 - (43%)	Gaps:	260/1142 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GWMQVFL-LLTVLVIGNQ----SAWQENIRPKLYVELGPEDVL-------------KFVGNESVV 94
            ||.::.: ||.:|::.::    |..::||         |.||:             :..||||
Zfish     2 GWRELTIDLLILLLVASRLDAVSFPEDNI---------PLDVVDRHYARQYPVFRGRPSGNES-- 55

  Fly    95 DH---FKLVTKDGNSLLIGARNTVFNLSI-----HDLVEQQRLVWTSPEDDTKMCLVKGKDEEAC 151
            .|   |:|:|:..::|.|..|:.|:.:|:     ::::..::|.|.|.:.|.:.|.:|||..:.|
Zfish    56 QHRLDFQLMTQIHDTLFIAGRDQVYLVSLRESYRNEIIPYRKLTWRSGQADRETCAMKGKHRDEC 120

  Fly   152 QNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNE 216
            .|:|:::|..:...:|:||||.|.|||..|.:.:..:..|.. :|.|.||:|.:..:.::.||.:
Zfish   121 HNFIKVLVPRNDDLVFICGTNGFNPMCRYYRLDNLEFDGEEI-SGLARCPFDAKQTNVALFADGK 184

  Fly   217 LYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINC 276
            |||.|||||..||.:|||     ..|:|.:|||..|..|:|:.:...||||||||||.|.|..|.
Zfish   185 LYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWLKEPHFLHAVDYGDFVYFFFREIAAEHNNL 249

  Fly   277 GKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMS 340
            |||:||||||:||.|.||..| ....||||:|:|||||:||:..|||:.:|:.:::::  ...:.
Zfish   250 GKAVYSRVARICKNDMGGSQRVLEKHWTSFVKARLNCSVPGESFFYFDVLQAITDIID--INGVP 312

  Fly   341 SKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--- 402
            |  :.|||.|..|||||||||||::.||...|.|:||||...:|.|.|....|:|.||||.|
Zfish   313 S--VVGVFTTQLNSIPGSAVCAFSMVDIEKAFRGRFKEQKTPDSVWTPFPEEKLPKPRPGCCAGH 375

  Fly   403 -----HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG-GKT 461
                 :..|...||.||.|||:|.|||.:||:...:|...:|...||.|.:|||   .|.| .|.
Zfish   376 GSAESYKTSIEFPDETLQFIKSHPLMDASVPSIGDEPWFTKTRVRYRLTALAVD---NTAGPHKN 437

  Fly   462 YDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPI-RNLEIVRTMQYDQPKDGSY 525
            |.|:|:|::.|.::|.:...|..|.:  .||::|||||..:::.: .|.:..|.:.:...||..
Zfish   438 YTVVFIGSEAGIVLKVLAKTSPLSLN--DSVLLEEIDVFNQAKCLSSNEDDRRILSFHLDKDSH- 499

  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCAWDKIAGKCRSHGA----PRWLEE 585
               .|.:...|.||.|.|.||  ::.:||.: |:|.:||||.|       .||||    |..::.
Zfish   500 ---TLYVAFSSCVVRIPLSRC--ERHSSCQKSCIASRDPYCGW-------MSHGACERIPATMQS 552

  Fly   586 NYFYQNVATGQHAACPSGKINSKDANAGEQKGF---RNDMDL-------------LDSRRQSKDQ 634
            .| .|:|..|..|............:|.:.|.:   .:||:|             :.|.:.:..|
Zfish   553 GY-EQDVEYGNTAHLGDCHEFLATTSAPDFKSYGDPTSDMELPSSSVTVPATSEPIQSPQTNPTQ 616

  Fly   635 --------------EIIDNIDKNFEGP-QISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-- 682
                          ..:::|....||. :|.|...|....:..|:..|||.   .||..|..|
Zfish   617 TPQLFEPHGDPATSHSVEHIPGVLEGVWEIQAGESNQMVHMNILISCVLAA---FLLGAFIAGMV 678

  Fly   683 YFC--------GRRCHKDED------------------------DNLPYPDTEYEYFEQRQNVNS 715
            .:|        .|:..||.:                        :..|..||...|.....|...
Zfish   679 VYCYRDAFLRTPRKIQKDAESAQSCTDSTGSFAKLNGLFDSPVKEYQPNLDTPKLYTNLLSNGRE 743

  Fly   716 FPSSCRIQ------QEPKL--LPQVEEVTYAE-----------------------------PVLL 743
            .|::...:      |.|:|  ||..|.....:                             |..|
Zfish   744 VPTTGETKTMLLSGQPPELAALPTPESTPVLQQKSLQPIKNQWERAHGKMSGSRKDAPPKSPQYL 808

  Fly   744 PQPPPPNKM---HSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVM 805
            |..|||:..   |.|...:.....|:...|.::       |:|...::..:..|..|:....:
Zfish   809 PSSPPPHSAINPHIPSAVVLPNATHENKAGFST-------PEGPQAEKKVQNSDQHGSKSGRK-- 864

  Fly   806 GDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSS 870
             |..|..|..:|...:.|.:|::|             |:..:|     ..|:.:|....:|..|.
Zfish   865 -DQRRTVDARNTLNDLLKHLNDSN-------------PKAIMV-----EMPKSRQHLMLEPIVSP 910

  Fly   871 GSSP--VMSNSSSSPAPPSSSP--SPQE---------SPKNCSYIYRDXLICNTKSMPLIQAQST 922
            ...|  |.|..:|..:|.||.|  ||.:         ||              |..|..::.|..
Zfish   911 TEIPPKVPSREASLYSPSSSLPRNSPTKRVDVPTTPTSP--------------TGHMGTLERQRY 961

  Fly   923 HAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGR-TYAKSMPVTPVQPQS---PLAETPSYELYE 983
            | :...|.|....||.|..:|.....:|.|.:.| .|....|..|.:..|   |:|.|||.....
Zfish   962 H-RGSSQRHSISSPPKGLHSPSGAIVSRQPSMNRGGYIPPTPTPPTRLDSHGVPMAMTPSVSRQS 1025

  Fly   984 RHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPP 1020
            .:|...:.          .....:.|:||....||.|
Zfish  1026 SYSGHGSL----------PRTSIKRTASLKPDVPPKP 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	190/478 (40%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	13/34 (38%)
sema6dl	XP_005173705.1	Sema	51..515	CDD:301699	191/479 (40%)
sema6dl	XP_005173705.1	PSI	516..570	CDD:279745	21/63 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1228
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000892
OrthoInspector	1	1.000	-	-		mtm6502
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4157
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.990