Protein Alignment Sema1a and sema6d

DIOPT Version :10

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_005173705.2
• Gene: sema6d / 550377
• ZFINID: ZDB-GENE-050417-171
• Length: 1070
• Species: Danio rerio
• Alignment Length: 1142
• Identity: 328/1142 - (28%)
• Similarity: 497/1142 - (43%)
• Gaps: 260/1142 - (22%)

  Fly    48 GWMQVFL-LLTVLVIGNQ----SAWQENIRPKLYVELGPEDVL-------------KFVGNESVV 94
            ||.::.: ||.:|::.::    |..::||         |.||:             :..||||
Zfish     2 GWRELTIDLLILLLVASRLDAVSFPEDNI---------PLDVVDRHYARQYPVFRGRPSGNES-- 55

  Fly    95 DH---FKLVTKDGNSLLIGARNTVFNLSI-----HDLVEQQRLVWTSPEDDTKMCLVKGKDEEAC 151
            .|   |:|:|:..::|.|..|:.|:.:|:     ::::..::|.|.|.:.|.:.|.:|||..:.|
Zfish    56 QHRLDFQLMTQIHDTLFIAGRDQVYLVSLRESYRNEIIPYRKLTWRSGQADRETCAMKGKHRDEC 120

  Fly   152 QNYIRIMVVPSPGRLFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVLADNE 216
            .|:|:::|..:...:|:||||.|.|||..|.:.:..:..|.. :|.|.||:|.:..:.::.||.:
Zfish   121 HNFIKVLVPRNDDLVFICGTNGFNPMCRYYRLDNLEFDGEEI-SGLARCPFDAKQTNVALFADGK 184

  Fly   217 LYSGTVADFSGSDPIIYR-----EPLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINC 276
            |||.|||||..||.:|||     ..|:|.:|||..|..|:|:.:...||||||||||.|.|..|.
Zfish   185 LYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWLKEPHFLHAVDYGDFVYFFFREIAAEHNNL 249

  Fly   277 GKAIYSRVARVCKWDKGGPHR-FRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMS 340
            |||:||||||:||.|.||..| ....||||:|:|||||:||:..|||:.:|:.:::::  ...:.
Zfish   250 GKAVYSRVARICKNDMGGSQRVLEKHWTSFVKARLNCSVPGESFFYFDVLQAITDIID--INGVP 312

  Fly   341 SKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--- 402
            |  :.|||.|..|||||||||||::.||...|.|:||||...:|.|.|....|:|.||||.|
Zfish   313 S--VVGVFTTQLNSIPGSAVCAFSMVDIEKAFRGRFKEQKTPDSVWTPFPEEKLPKPRPGCCAGH 375

  Fly   403 -----HNDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPG-GKT 461
                 :..|...||.||.|||:|.|||.:||:...:|...:|...||.|.:|||   .|.| .|.
Zfish   376 GSAESYKTSIEFPDETLQFIKSHPLMDASVPSIGDEPWFTKTRVRYRLTALAVD---NTAGPHKN 437

  Fly   462 YDVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPI-RNLEIVRTMQYDQPKDGSY 525
            |.|:|:|::.|.::|.:...|..|.:  .||::|||||..:::.: .|.:..|.:.:...||..
Zfish   438 YTVVFIGSEAGIVLKVLAKTSLLSLN--DSVLLEEIDVFNQAKCLSSNEDDRRILSFHLDKDSH- 499

  Fly   526 DDGKLIIVTDSQVVAIQLHRCHNDKITSCSE-CVALQDPYCAWDKIAGKCRSHGA----PRWLEE 585
               .|.:...|.||.|.|.||  ::.:||.: |:|.:||||.|       .||||    |..::.
Zfish   500 ---TLYVAFSSCVVRIPLSRC--ERHSSCQKSCIASRDPYCGW-------MSHGACERIPATIQS 552

  Fly   586 NYFYQNVATGQHAACPSGKINSKDANAGEQKGF---RNDMDL-------------LDSRRQSKDQ 634
            .| .|:|..|..|............:|.:.|.:   .:||:|             :.|.:.:..|
Zfish   553 GY-EQDVEYGNTAHLGDCHEFLATTSAPDFKSYGDPTSDMELPSSSVTVPATSEPIQSPQTNPTQ 616

  Fly   635 --------------EIIDNIDKNFEGP-QISADIINAQYTVETLVMAVLAGSIFSLLVGFFTG-- 682
                          ..:::|....||. :|.|...|....:..|:..|||.   .||..|..|
Zfish   617 TPQLFEPHGDPATSHSVEHIPGVLEGVWEIQAGESNQMVHMNILISCVLAA---FLLGAFIAGMV 678

  Fly   683 YFC--------GRRCHKDED------------------------DNLPYPDTEYEYFEQRQNVNS 715
            .:|        .|:..||.:                        :..|..||...|.....|...
Zfish   679 VYCYRDAFLRTPRKIQKDAESAQSCTDSTGSFAKLNGLFDSPVKEYQPNMDTPKLYTNLLSNGRE 743

  Fly   716 FPSSCRIQ------QEPKL--LPQVEEVTYAE-----------------------------PVLL 743
            .|::...:      |.|:|  ||..|.....:                             |..|
Zfish   744 VPTTGETKTMLLSGQPPELAALPTPESTPVLQQKSLQPIKNQWERAHGKMSGSRKDAPPKSPQYL 808

  Fly   744 PQPPPPNKM---HSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVM 805
            |..|||:..   |.|...:.....|:...|.::       |:|...::..:..:..|:....:
Zfish   809 PSSPPPHSAINPHIPSAVVLPNATHENKAGFST-------PEGPQAEKKVQNSEQHGSKSGRK-- 864

  Fly   806 GDNYRRGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRHGIVTQHRSNSPQQQQQQSQQPHSSS 870
             |..|..|..:|...:.|.:|::|             |:..:|     ..|:.:|....:|..|.
Zfish   865 -DQRRTVDARNTLNDLLKHLNDSN-------------PKAIMV-----EMPKSRQHLMLEPIVSP 910

  Fly   871 GSSP--VMSNSSSSPAPPSSSP--SPQE---------SPKNCSYIYRDXLICNTKSMPLIQAQST 922
            ...|  |.|..:|..:|.||.|  ||.:         ||              |..|..::.|..
Zfish   911 TEIPPKVPSREASLYSPSSSLPRNSPTKRVDVPTTPTSP--------------TGHMGTLERQRY 961

  Fly   923 HAQPHPQSHPHPLPPPGPTTPPAQPRARSPMIGR-TYAKSMPVTPVQPQS---PLAETPSYELYE 983
            | :...|.|....||.|..:|.....:|.|.:.| .|....|..|.:..|   |:|.|||.....
Zfish   962 H-RGSSQRHSISSPPKGLHSPSGAIVSRQPSMNRGGYIPPTPTPPTRLDSHGVPMAMTPSVSRQS 1025

  Fly   984 RHSDAATFHFGDEDDDDDDEHDHEDTSSLAMITPPPP 1020
            .:|...:.          .....:.|:||....||.|
Zfish  1026 SYSGHGSL----------PRTSIKRTASLKPDVPPKP 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	190/478 (40%)
		PSI	545..601	CDD:396154	21/60 (35%)
sema6d	XP_005173705.2	None