Protein Alignment Sema1a and SEMA4C

DIOPT Version :9

• Sequence 1: NP_001260265.1
• Gene: Sema1a / 34192
• FlyBaseID: FBgn0011259
• Length: 1131
• Species: Drosophila melanogaster
• Sequence 2: XP_016859882.1
• Gene: SEMA4C / 54910
• HGNCID: 10731
• Length: 875
• Species: Homo sapiens
• Alignment Length: 647
• Identity: 213/647 - (32%)
• Similarity: 315/647 - (48%)
• Gaps: 103/647 - (15%)

  Fly    52 VFLL---LTVLVIGNQSAWQENIRPKLYVELGP-EDVLKFVGNESVVDHFKLVTKDGNSLL-IGA 111
            |:||   |..|.||.:..|  |:.|:..|..|. ..|::......:.|...|...:...|| :||
Human    49 VWLLAARLWGLGIGAEVWW--NLVPRKTVSSGELATVVRRFSQTGIQDFLTLTLTEPTGLLYVGA 111

  Fly   112 RNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCGTNSFR 175
            |..:|..|:..|..|..:.|.:|.:....|:.|||:.:. |.|:||.:...:...|:||||.:|:
Human   112 REALFAFSMEALELQGAISWEAPVEKKTECIQKGKNNQTECFNFIRFLQPYNASHLYVCGTYAFQ 176

  Fly   176 PMCNTYIISDSNYTLE--ATKNGQAVCPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYR---- 234
            |.| || ::...:|||  ..::|:..|||||......:|.|.||||.|:.:|.|::|||.|
Human   177 PKC-TY-VNMLTFTLEHGEFEDGKGKCPYDPAKGHAGLLVDGELYSATLNNFLGTEPIILRNMGP 239

  Fly   235 -EPLQTEQYDSLSLNAPNF---------VSSFT-QGDFVYFFFRETAVEFINCGKAIYSRVARVC 288
             ..::|| |.:..||.|:|         |.||| ..|.|||||||.|||.....:.:.:||||||
Human   240 HHSMKTE-YLAFWLNEPHFVGSAYVPESVGSFTGDDDKVYFFFRERAVESDCYAEQVVARVARVC 303

  Fly   289 KWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFNTPSN 353
            |.|.||....:.:||:|||:||.||.| ::..|||::|:...|   |..|..:...:|||.....
Human   304 KGDMGGARTLQRKWTTFLKARLACSAP-NWQLYFNQLQAMHTL---QDTSWHNTTFFGVFQAQWG 364

  Fly   354 SIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHND---------SRAL 409
            .:..||:|.:.|::|...|||.:||.......|....: .||.||||||.|:         |..|
Human   365 DMYLSAICEYQLEEIQRVFEGPYKEYHEEAQKWDRYTD-PVPSPRPGSCINNWHRRHGYTSSLEL 428

  Fly   410 PDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKI 474
            ||..|||:|.|.||:|.|...:|:|:||:..|  .||.:..| ::....|.||.|:|:||..|.:
Human   429 PDNILNFVKKHPLMEEQVGPRWSRPLLVKKGT--NFTHLVAD-RVTGLDGATYTVLFIGTGDGWL 490

  Fly   475 IKSVNAESADSADKVTSV-----VIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIV- 533
            :|:|            |:     :|||:. |...||:|:|.:      .|.|       ||:..
Human   491 LKAV------------SLGPWVHLIEELQ-LFDQEPMRSLVL------SQSK-------KLLFAG 529

  Fly   534 TDSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHA 598
            :.||:|.:.:..|.  |..||::||..:||||||.....:|                 ||.|.|
Human   530 SRSQLVQLPVADCM--KYRSCADCVLARDPYCAWSVNTSRC-----------------VAVGGH- 574

  Fly   599 ACPSGKINSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGP-QISADIINAQYT 659
               ||.:..:.....:..|..|.......|...|:..::...|...  | .:|:::.:|::|
Human   575 ---SGSLLIQHVMTSDTSGICNLRGSKKVRPTPKNITVVAGTDLVL--PCHLSSNLAHARWT 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	172/488 (35%)
		PSI	545..>579	CDD:214655	13/33 (39%)
SEMA4C	XP_016859882.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910