DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema3gb

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005167089.1	Gene:	sema3gb / 544660	ZFINID:	ZDB-GENE-050513-4	Length:	746	Species:	Danio rerio

Alignment Length:	821	Identity:	216/821 - (26%)
Similarity:	360/821 - (43%)	Gaps:	183/821 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 LLLTVLVIGNQSAW--QENIRPKLYVELGPEDVLK--------FVGNESVVDHFKL-VTKDGNSL 107
            ::.::|.:.:...|  ..|.|....|.|..:::|:        |..|.|  |:..| :.:|...|
Zfish     1 MMSSLLFVLSLCVWGCHGNTRTTPRVHLSYKELLETKTIRPFSFSFNTS--DYRILHMDQDQGRL 63

  Fly   108 LIGARNTVFNLSIHDLVEQQRLV-WTSPEDDTKMCLVKGKDEEA-CQNYIRIMVVPSPGRLFVCG 170
            .:|:|..:.:|.:.::.::..:: |.:.......|.:.||..:. |.|::|::...:...|:.||
Zfish    64 YLGSREYLVSLDMQNVNKEPLIIHWPATTQRKGECKLTGKGGQGECANFVRLIEPWNRTHLYTCG 128

  Fly   171 TNSFRPMCNTYIISDSNYTLEA---------TKNGQAVCPYDPRHNSTSVLADNELYSGTVADFS 226
            |.:::|:| |:|  :..:..|.         ..:|:...|||||..:.:.|.:..||||...||.
Zfish   129 TGAYKPIC-TFI--NRGWRAEEYLFRLVPGYVDSGKGKSPYDPRQENAAALINGNLYSGVHVDFM 190

  Fly   227 GSDPIIY-----REPLQTEQYDSLSLNAPNFV-------SSFTQGDFVYFFFRETAVEFINCGKA 279
            |:||.|:     |..::||||||..||.|.|:       |:....|.:||||||.::: .:.|.|
Zfish   191 GTDPAIFRTLGDRPAVRTEQYDSRWLNEPVFIKIQKIPDSAEKNDDKLYFFFREKSLD-ASGGSA 254

  Fly   280 --IYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG--DYPFYFNEIQSASNLVEGQYGSMS 340
              :.:||.|||..|.||.....|:||:|||:||.||:.|  ....||:|::..  .::..:.. .
Zfish   255 PSVLARVGRVCLNDDGGQRSLVNKWTTFLKARLVCSVIGADGVETYFDELRDV--FIQRTHDE-R 316

  Fly   341 SKLIYGVFNTPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCH-- 403
            :.::|.||:|..:...|||||.:::.||.:.|.|.|..:.|.|..|.|. ..|:|.||||:|.
Zfish   317 NPIVYAVFSTAGSVFKGSAVCVYSMSDIRNVFNGPFSHKHGHNYQWTPY-TGKIPYPRPGTCPGG 380

  Fly   404 ------NDSRALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTY 462
                  :.::|..|..:||::.|.||.:.:.....:|::|||...||||.||||......|  .|
Zfish   381 TFTPDLHTTKAFSDEAVNFVRAHPLMYQPIYPIHKRPLVVRTGVDYRFTTIAVDLVDAVDG--RY 443

  Fly   463 DVIFVGTDHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDD 527
            :|:|:|||.|.:.|.:......|..:  .:::||::|......::.|:|....|
Zfish   444 EVLFLGTDRGTVQKVIVLPKDISTTE--ELILEEVEVFKTPAAVKTLKISTKRQ----------- 495

  Fly   528 GKLIIVTDSQVVAIQLHRC--HNDKITSCSECVALQDPYCAWD-------KIAGKCRS------H 577
             :|.:.::..:..:.||||  :.   .:||:|...:|||||||       ..|.|.||      |
Zfish   496 -QLYVSSERGLTQVSLHRCAVYG---KACSDCCLARDPYCAWDGEHCSAFTPATKRRSRRQDIKH 556

  Fly   578 GAP----RWLE---ENYFYQNVATGQHAACPSGKINSKDANAGEQKGFRNDMDLLDSRRQ--SKD 633
            |.|    |...   |....:.|..|...:....:...:...|..:..|:.     |.||:  |:|
Zfish   557 GDPLRQCRGFNAKVEKRLRETVQFGVEGSSTFLECQPRSPQATVKWLFQK-----DGRRKALSRD 616

  Fly   634 QEIIDNIDKNFEG------PQISADII-------NAQYTVETLVMAVLAGSIFSLLVGFFTGYFC 685
            :|::    |...|      .|..|.:.       |.::|:..:.:.:|...|...|.
Zfish   617 KEVL----KTGHGILLKSLTQSDAGLYHCLATENNFKHTLARISLRILDREIVEALT-------- 669

  Fly   686 GRRCHKDEDDNLPYPDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPN 750
                    :.::|. |.|:    :|.:.:..|                          |.||||.
Zfish   670 --------ESDIPI-DPEH----RRHHSHQHP--------------------------PPPPPPP 695

  Fly   751 KMHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYR 791
            :.|        ||...:|..|....:.|:       .||||
Zfish   696 QAH--------PPALPLHPQPEVRLINQY-------CQSYR 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	147/490 (30%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	17/48 (35%)
sema3gb	XP_005167089.1	Sema_3F	42..513	CDD:200515	149/496 (30%)
		PSI	512..558	CDD:214655	17/48 (35%)
		Ig_Semaphorin_classIII	576..662	CDD:143279	17/94 (18%)
		IG_like	581..651	CDD:214653	14/78 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.910