DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and SEMA5B

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_001243276.1	Gene:	SEMA5B / 54437	HGNCID:	10737	Length:	1205	Species:	Homo sapiens

Alignment Length:	1039	Identity:	309/1039 - (29%)
Similarity:	441/1039 - (42%)	Gaps:	243/1039 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 GWMQVFLL---LTVLVIGNQSAWQENIRPKLYVEL---------GPEDVLKFVGN---ESVVDHF 97
            |.:.|.||   ||:||....|:...:..|....:|         ..||:..:|.|   ....|..
Human   117 GPLAVSLLLPSLTLLVSHLSSSQDVSSEPSSEQQLCALSKHPTVAFEDLQPWVSNFTYPGARDFS 181

  Fly    98 KL-VTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVP 161
            :| :...||.|::||||.:|.||:.::...|...|.|.||..:.|..|||.||.||||:|:::|
Human   182 QLALDPSGNQLIVGARNYLFRLSLANVSLLQATEWASSEDTRRSCQSKGKTEEECQNYVRVLIV- 245

  Fly   162 SPGR-LFVCGTNSFRPMCNTYIISDSNYTLEATKNGQAVCPYDPRHNSTSVL-ADNELYSGTVAD 224
             .|| :|:||||:|.|||.:..:.:.:.|:|.. ||.|.||||||||||:|: :..|||:.||.|
Human   246 -AGRKVFMCGTNAFSPMCTSRQVGNLSRTIEKI-NGVARCPYDPRHNSTAVISSQGELYAATVID 308

  Fly   225 FSGSDPIIYRE-----PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRV 284
            |||.||.|||.     ||:|.||:|..||.||||:::..|.|.|||.||.|||. :||:.:||||
Human   309 FSGRDPAIYRSLGSGPPLRTAQYNSKWLNEPNFVAAYDIGLFAYFFLRENAVEH-DCGRTVYSRV 372

  Fly   285 ARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFN 349
            |||||.|.||.....:.||:|:|:|||||.||:.|||:||:|||.:|.|       ..||||||.
Human   373 ARVCKNDVGGRFLLEDTWTTFMKARLNCSRPGEVPFYYNELQSAFHLPE-------QDLIYGVFT 430

  Fly   350 TPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPD------PRPGSCHN-DSR 407
            |..|||..||||||.|..|:..|.|.|:.|....:.|||:.| .:|:      |..|...| ..|
Human   431 TNVNSIAASAVCAFNLSAISQAFNGPFRYQENPRAAWLPIAN-PIPNFQCGTLPETGPNENLTER 494

  Fly   408 ALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVD-AQIKTPGGKTYDVIFVGTDH 471
            :|.|....|     ||.|.|.....:|.:.:.|.  ||:.:.|| .|.|   ...|.|:::||:.
Human   495 SLQDAQRLF-----LMSEAVQPVTPEPCVTQDSV--RFSHLVVDLVQAK---DTLYHVLYIGTES 549

  Fly   472 GKIIKSVNAESADSADKVTSVVIEEIDVLT--KSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVT 534
            |.|:|:::..|.    .:....:||:.||.  :.||:|:|.|:.:.:            .|.:..
Human   550 GTILKALSTASR----SLHGCYLEELHVLPPGRREPLRSLRILHSAR------------ALFVGL 598

  Fly   535 DSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEE----NYFYQNVATG 595
            ...|:.:.|.||  ....|...|:..:||||.||....:|.:      ||:    :.:.||:
Human   599 RDGVLRVPLERC--AAYRSQGACLGARDPYCGWDGKQQRCST------LEDSSNMSLWTQNI--- 652

  Fly   596 QHAACPSGKINSKDANAG---------EQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISA 651
              .|||...: ::|...|         ...|..:...|..:|.....:.....:|  ..||.|
Human   653 --TACPVRNV-TRDGGFGPWSPWQPCEHLDGDNSGSCLCRARSCDSPRPRCGGLD--CLGPAI-- 710

  Fly   652 DIINAQYTVETLVMAVLAGSIFSLLVGF-------------FTGYFCGRRCHKDE--DDNLPYPD 701
            .|.|..........:..|....|..:||             ..|..|..:..::.  ::|.|.|.
Human   711 HIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPV 775

  Fly   702 TEY---------------EYFEQR----QNVNSFPSSCRIQQE---PKLLPQVEEVTYAEPVLLP 744
            ..:               ...:.|    :|.||. ..|.::.:   |:..|:|...|...|.|
Human   776 PIFWASWGSWSKCSSNCGGGMQSRRRACENGNSC-LGCGVEFKTCNPEGCPEVRRNTPWTPWL-- 837

  Fly   745 QPPPPNKMHSPKNTLRKPPMHQMHQGPNSETLFQF-------QPDGY-----NTQQSYRGRDNFG 797
                              |::....|...|..|:|       .|.|.     .|:......|..|
Human   838 ------------------PVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSG 884

  Fly   798 T----------LRS-----HQVMGDNYRRGDGFSTTRSV-------KKAVNNTNTRNRSLGRARR 840
            :          |||     |.|.|.....|...|.:|..       |:...|...||..|
Human   885 SCDTDALVEVLLRSGSTSPHTVSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGL----- 944

  Fly   841 QPPRHGIVTQHRSNSPQQQQQQ-------SQQPHSSS--GSSPVMSNSSSSPAPPSSSPSPQESP 896
              |..|...:::..:||....:       |..|.|:|  |.....:.|.:|||     |||.|.
Human   945 --PCVGDAAEYQDCNPQACPVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPA-----PSPGED- 1001

  Fly   897 KNCSYIYRDXLICNTKSMP--------------------------LIQAQSTHAQPHPQSHPHP 934
             .|..::.: .:|.|::.|                          |:...|..|....||.|.|
Human  1002 -ICLGLHTEEALCATQACPEGWSPWSEWSKCTDDGAQSRSRHCEELLPGSSACAGNSSQSRPCP 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	193/472 (41%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/33 (33%)
SEMA5B	NP_001243276.1	Sema_5B	172..608	CDD:200525	192/473 (41%)
		PSI	609..656	CDD:279745	16/59 (27%)
		TSP1	667..718	CDD:214559	10/54 (19%)
		TSP1	721..774	CDD:214559	8/52 (15%)
		TSP1	779..825	CDD:214559	6/46 (13%)
		TSP1	910..962	CDD:214559	12/58 (21%)
		TSP1	967..1019	CDD:214559	16/58 (28%)
		TSP_1	1023..1064	CDD:278517	6/40 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810