DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and PLXNA2

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	XP_005273221.1	Gene:	PLXNA2 / 5362	HGNCID:	9100	Length:	1974	Species:	Homo sapiens

Alignment Length:	978	Identity:	205/978 - (20%)
Similarity:	342/978 - (34%)	Gaps:	296/978 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMC----LVKGKDE--EACQNYIRIMVVP-SP 163
            ::.:||.|.|:.|:.:..::....  |.||:|.|.|    :|:...|  ....|..:::::. |.
Human    76 AVYVGAINRVYKLTGNLTIQVAHK--TGPEEDNKSCYPPLIVQPCSEVLTLTNNVNKLLIIDYSE 138

  Fly   164 GRLFVCGTNSFRPMCNTYIISD-----------SNYTLEATKN-------------------GQA 198
            .||..|| :.::.:|....:.|           .:|.....|.                   |.|
Human   139 NRLLACG-SLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA 202

  Fly   199 V--------------CPYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREPLQT----EQYDSL 245
            |              .|.||   .:|.:.|.||:|    ||..|   :.:.|..|    ..:|..
Human   203 VDGKQDYFPTLSSRKLPRDP---ESSAMLDYELHS----DFVSS---LIKIPSDTLALVSHFDIF 257

  Fly   246 SLNAPNFVSSFTQGDFVYFFF--RET--AVEFINCGKAIY-SRVARVCKWDKGGPHRFRNRWTSF 305
                  ::..|..|.||||..  .||  .|...:.|...| ||:.|:||.|.        ::.|:
Human   258 ------YIYGFASGGFVYFLTVQPETPEGVAINSAGDLFYTSRIVRLCKDDP--------KFHSY 308

  Fly   306 LKSRLNCSIPGDYPFYFNEIQSA------SNLVEGQYGSMSSKLIYGVFNTPSNSI----PGSAV 360
            :.....|:..|   ..:..:|:|      .:|.:....:....:::.:|:......    ..||:
Human   309 VSLPFGCTRAG---VEYRLLQAAYLAKPGDSLAQAFNITSQDDVLFAIFSKGQKQYHHPPDDSAL 370

  Fly   361 CAFALQ----DIADTFEGQFKEQTGINSNWL---PVNNAKVPDPRPGSCHNDSRALPDPTLNFIK 418
            |||.::    .|.:..:..::.:..:..|||   .|...|.|.|           :.|   ||..
Human   371 CAFPIRAINLQIKERLQSCYQGEGNLELNWLLGKDVQCTKAPVP-----------IDD---NFCG 421

  Fly   419 THSLMDENVPAFFSQPILVRTSTIY-----RFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSV 478
                :|.|.|...|.|  |...|:|     |.|.:|....      ..|.|:||||..|| :|.:
Human   422 ----LDINQPLGGSTP--VEGLTLYTTSRDRMTSVASYVY------NGYSVVFVGTKSGK-LKKI 473

  Fly   479 NAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQL 543
            .|:.....    .|..|.:.||....|     |:|.|.:      |.|...|.::::.||..:.:
Human   474 RADGPPHG----GVQYEMVSVLKDGSP-----ILRDMAF------SIDQRYLYVMSERQVTRVPV 523

  Fly   544 HRCHNDKITSCSECVALQDPYCAWDKIAGKC--RSHGAPRWLEENYFY-------------QNVA 593
            ..|  ::.|:|.||::..||:|.|..:...|  |......| |.|.|.             .:::
Human   524 ESC--EQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQQAW-EPNRFAASISQCVSLAVHPSSIS 585

  Fly   594 TGQHAACPSGKI-NSKDANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQ 657
            ..:|:...|..: ::.|.:||....|.|   |.:...|....::|.......:.|.|..|  ...
Human   586 VSEHSRLLSLVVSDAPDLSAGIACAFGN---LTEVEGQVSGSQVICISPGPKDVPVIPLD--QDW 645

  Fly   658 YTVETLVMAVLAGSIFSLLVGFFTGYFCGR------------RCHKDEDDNL-PYPDTEYEYFEQ 709
            :.:|..:.:...|.||  :...|..|.|..            |||..:..|| .:..|...:.|.
Human   646 FGLELQLRSKETGKIF--VSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEG 708

  Fly   710 RQNVNSFPSSCRIQQEPKLLPQVE---EVTYAEPVL-----LPQPPPPNKMHSPKNTLRKPPMHQ 766
            |.|::   ..|     |:|:|..|   .|...:|:.     ||||....:.:.....::    ..
Human   709 RINIS---EDC-----PQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLNIQ----GA 761

  Fly   767 MHQGP----NSETLFQFQPDGYNTQQSYRGRD------NFGTLRSHQVMGDNYRRGDGFSTTRSV 821
            :|:.|    ||.:: |.|    |:...|.|.|      :|..:.:...:.||         .:.:
Human   762 IHRVPALRFNSSSV-QCQ----NSSYQYDGMDISNLAVDFAVVWNGNFIIDN---------PQDL 812

  Fly   822 KKAVNNTNTRNRSLGRARRQPPRH--GIVTQHRSNSPQQQQQQSQQPHSSSGSSPVMSNSS---- 880
            |..:.....:..|.|...:...:.  |..:..|..:..|        |.:|.|||.:..||
Human   813 KVHLYKCAAQRESCGLCLKADRKFECGWCSGERRCTLHQ--------HCTSPSSPWLDWSSHNVK 869

  Fly   881 -SSP---------APPSS-----------------------------SPSPQESPKNCSYIYRDX 906
             |:|         .||..                             :|.|.|      ||..:.
Human   870 CSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPLPGE------YIIAEQ 928

  Fly   907 LIC 909
            ::|
Human   929 IVC 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	114/521 (22%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/35 (31%)
PLXNA2	XP_005273221.1	Sema_plexin_A2	53..567	CDD:200533	128/565 (23%)
		PSI	670..717	CDD:279745	11/54 (20%)
		PSI	821..870	CDD:279745	12/56 (21%)
		IPT_plexin_repeat1	873..968	CDD:238585	9/65 (14%)
		IPT_plexin_repeat2	969..1052	CDD:238584
		IPT_plexin_repeat3	1056..1156	CDD:238586
		TIG	1158..1242	CDD:280079
		Plexin_cytopl	1326..1944	CDD:285529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910