DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and PLXNA1

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_115618.3	Gene:	PLXNA1 / 5361	HGNCID:	9099	Length:	1896	Species:	Homo sapiens

Alignment Length:	1107	Identity:	223/1107 - (20%)
Similarity:	372/1107 - (33%)	Gaps:	334/1107 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVLVIGNQSAWQENIRPKLYVELGPEDVLK-FVGNESVVDHFKLVTKDGNSLLIGARN 113
            :||.|||.:|::.....|.|...|:  ...|.:...: |..::..:.|. :|.:....:.:||.|
Human     8 LQVLLLLLLLLLLLPGMWAEAGLPR--AGGGSQPPFRTFSASDWGLTHL-VVHEQTGEVYVGAVN 69

  Fly   114 TVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEAC-------QNYIRIMVVP-SPGRLFVCG 170
            .::.||.:  :...|...|.|.:|.:.| ......::|       .|..:::::. :..||..||
Human    70 RIYKLSGN--LTLLRAHVTGPVEDNEKC-YPPPSVQSCPHGLGSTDNVNKLLLLDYAANRLLACG 131

  Fly   171 TNSFRPMCNTYIISD----------SNYTLEATK---------------NGQA----------VC 200
            :.| :.:|....:.|          ..:.|.:.:               .|||          ..
Human   132 SAS-QGICQFLRLDDLFKLGEPHHRKEHYLSSVQEAGSMAGVLIAGPPGQGQAKLFVGTPIDGKS 195

  Fly   201 PYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREPLQTEQY----DSLSLNAPNF----VSSFT 257
            .|.|..:|..::|:.|     .||..|   .:|::...:.|.    |:|| ..|.|    |.||.
Human   196 EYFPTLSSRRLMANEE-----DADMFG---FVYQDEFVSSQLKIPSDTLS-KFPAFDIYYVYSFR 251

  Fly   258 QGDFVYFFFRETAVEFIN---CGKAIY-SRVARVCKWDKGGPHRFRNRWTSFLKSRLNCSIPG-D 317
            ...|||:...:...:..:   .|:..: |::.|:|..|.        ::.|:::..:.|...| :
Human   252 SEQFVYYLTLQLDTQLTSPDAAGEHFFTSKIVRLCVDDP--------KFYSYVEFPIGCEQAGVE 308

  Fly   318 YPFYFNEIQSASNLVEGQYGSMSSK-------------LIYGVF-NTPSNSI---PGSAVCAFAL 365
            |           .||:..|.|...:             :::.|| ....|.:   ..||:|.|.|
Human   309 Y-----------RLVQDAYLSRPGRALAHQLGLAEDEDVLFTVFAQGQKNRVKPPKESALCLFTL 362

  Fly   366 QDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDSRALPDP-----TLNFIKTHSLMDE 425
            :.|.:    :.||                   |..||:.....|..|     .|..|.:...:|:
Human   363 RAIKE----KIKE-------------------RIQSCYRGEGKLSLPWLLNKELGCINSPLQIDD 404

  Fly   426 NVPAF----FSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYD-----VIFVGTDHG---KIIKSV 478
            :   |    |:|| |..|.|| ..|.:.||..........||     |:|.||..|   ||:..:
Human   405 D---FCGQDFNQP-LGGTVTI-EGTPLFVDKDDGLTAVAAYDYRGRTVVFAGTRSGRIRKILVDL 464

  Fly   479 NAESADSADKVTSVVIEEIDVLTKSEPI-RNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQ 542
            :......|....|||.:|      ..|| |:|.:....||            |..:|:.||..:.
Human   465 SNPGGRPALAYESVVAQE------GSPILRDLVLSPNHQY------------LYAMTEKQVTRVP 511

  Fly   543 LHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFY--------QNVATGQHAA 599
            :..|  .:.|||..|:..:||:|.|..:...|....|....:|...:        |.....::.:
Human   512 VESC--VQYTSCELCLGSRDPHCGWCVLHSICSRRDACERADEPQRFAADLLQCVQLTVQPRNVS 574

  Fly   600 CPSGKI-------NSKDANAGEQKGF----RNDMDLLDSR---------------RQSKDQEIID 638
            ....::       |..|.:||....|    .::..|.|.|               |...||.::.
Human   575 VTMSQVPLVLQAWNVPDLSAGVNCSFEDFTESESVLEDGRIHCRSPSAREVAPITRGQGDQRVVK 639

  Fly   639 NIDKNFE-GPQI-SADIINAQYTVETLVMAVLAGSIFSLLVGFFTGYFCGRR--CHKDEDDNLPY 699
            ...|:.| |.:. |.|.:....:|..        |..|.:.|.|..::|..|  |..:..|
Human   640 LYLKSKETGKKFASVDFVFYNCSVHQ--------SCLSCVNGSFPCHWCKYRHVCTHNVAD---- 692

  Fly   700 PDTEYEYFEQRQNVNSFPSSCRIQQEPKLLPQVE---EVTYAEPVL-----LPQPPPPNK----- 751
                ..:.|.|.||:   ..|     |::||..:   .|...:|:.     ||||....:
Human   693 ----CAFLEGRVNVS---EDC-----PQILPSTQIYVPVGVVKPITLAARNLPQPQSGQRGYECL 745

  Fly   752 MHSPKNTLRKPPMHQMHQGPNSETLFQFQPDGYNTQQSYRGRD------NFGTLRSHQVMGDNYR 810
            .|.|.:..|...:..     ||.:| |.|    |:..||.|.|      |...:.:...:.||
Human   746 FHIPGSPARVTALRF-----NSSSL-QCQ----NSSYSYEGNDVSDLPVNLSVVWNGNFVIDN-- 798

  Fly   811 RGDGFSTTRSVKKAVNNTNTRNRSLGRARRQPPRH--GIVTQHRSNSPQQQQQQSQQPHSSSGSS 873
                   .::::..:........|.|...:..||.  |.....|..|.:         |..:..:
Human   799 -------PQNIQAHLYKCPALRESCGLCLKADPRFECGWCVAERRCSLR---------HHCAADT 847

  Fly   874 P-----VMSNSSSSPAPPSSSPSPQESPKN-----------------------------CS---- 900
            |     ....||....|.....||:..|:.                             ||
Human   848 PASWMHARHGSSRCTDPKILKLSPETGPRQGGTRLTITGENLGLRFEDVRLGVRVGKVLCSPVES 912

  Fly   901 -YIYRDXLICNTKSMPLIQAQST-------HAQPHPQS-HPHPLPPPGPTTPPAQPRARSPMIGR 956
             ||..:.::|.......::|...       ...||.:: .|.......||.....| :|.|:.|.
Human   913 EYISAEQIVCEIGDASSVRAHDALVEVCVRDCSPHYRALSPKRFTFVTPTFYRVSP-SRGPLSGG 976

  Fly   957 TY 958
            |:
Human   977 TW 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	113/545 (21%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	10/33 (30%)
PLXNA1	NP_115618.3	Sema_plexin_A1	38..513	CDD:200532	114/553 (21%)
		PSI	514..>556	CDD:279745	12/43 (28%)
		PSI	660..707	CDD:279745	14/70 (20%)
		PSI	809..862	CDD:279745	11/61 (18%)
		IPT_plexin_repeat1	864..960	CDD:238585	13/95 (14%)
		IPT_plexin_repeat2	961..1046	CDD:238584	7/19 (37%)
		IPT_plexin_repeat3	1048..1148	CDD:238586
		TIG	1150..1234	CDD:280079
		Plexin_cytopl	1318..1866	CDD:285529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910