DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and PlexA

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_524637.2	Gene:	PlexA / 43832	FlyBaseID:	FBgn0025741	Length:	1945	Species:	Drosophila melanogaster

Alignment Length:	989	Identity:	192/989 - (19%)
Similarity:	341/989 - (34%)	Gaps:	288/989 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 ESVVDHFKLVTKDGNSLLIGARNTVFNLSIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQ--- 152
            ::.::|..:.|..|. :.:|..|.::.|| .|| |....|.|.|::|:..|.:......|.:
  Fly    72 DTKLNHLLVDTITGR-VFVGGVNRLYQLS-PDL-ELSETVKTGPQNDSVECSILDCPLNAVRSPT 133

  Fly   153 -NYIRIMVVP-SPGRLFVC-----GTNSFRPMCNTYII----------SDSNYTLEATKNGQAVC 200
             ||.:::::. :..||..|     ||.:.|.:.|..||          :|:|.:..|     .:.
  Fly   134 DNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSIIEHEVPDAVVANDANSSTVA-----FIA 193

  Fly   201 PYDPRHNSTSVLADNELYSGTVADFSGSDPIIYREPLQTEQYDSLSLNA---------------- 249
            |..|:|..|:|:.....|:.. :.:....|.:....|:..:...::.:|
  Fly   194 PGPPQHPVTNVMYVGVTYTNN-SPYRSEIPAVASRSLEKTKMFQIASSAVTTGTRTFINSYARET 257

  Fly   250 --PNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVARVCKWDKGGPHRFRNRWTSFLKSRLNC 312
              .|:|..|:...|.||...:......:..|...:::.|:|:.|        :.:.|:.:..:.|
  Fly   258 YFVNYVYGFSSERFSYFLTTQLKHSHHSSPKEYITKLVRICQED--------SNYYSYTEIPVEC 314

  Fly   313 SIPGDYPFYFNEIQS------ASNLVEGQYGSMSSKLIYGVF-----NTPSNSIPGSAVCAFALQ 366
            .........||.:|:      :|:|.:....|:...:::.||     |||:|:   ||:|.::|:
  Fly   315 ISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGNTPTNN---SALCIYSLK 376

  Fly   367 DIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSCHNDS--RAL----PDPTLNFIKTHSL--- 422
            .|...|                :.|.|       ||.|.|  |.|    |.......|..::
  Fly   377 SIRRKF----------------MQNIK-------SCFNGSGMRGLDFISPSMPCVLTKLQTIGED 418

  Fly   423 ---MDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGGKTYDVIFVGTDHGKIIKSVNAESAD 484
               :|.|.|.....||......::. |::...|...|.|   |.|:||||..| .:|.|..||:.
  Fly   419 FCGLDVNSPLGGETPITSVPVAMFN-TKLTSVAATSTSG---YTVVFVGTSDG-FLKKVVIESSS 478

  Fly   485 SADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVTDSQVVAIQLHRCHND 549
            .|::..|..::           ...||.|.||:|......|      :::.::|..:::..|.:.
  Fly   479 IANEYASFAVD-----------LGSEINRDMQFDNQNLYIY------VMSKTKVSKVKVFDCSDY 526

  Fly   550 KITSCSECVALQDPYCAWDKIAGKCRSHGAPRW-----LEENYFYQNVATGQHAACPSGKINSKD 609
            |  :|.:|:..:||||.|..:..||    :||.     ..:..::.:..||:.....|...:..
  Fly   527 K--TCGDCLGARDPYCGWCSLENKC----SPRSNCQDDANDPLYWVSYKTGKCTTITSVVPHQL- 584

  Fly   610 ANAGEQKGFRNDMDLLDSRRQSKDQEIIDNIDKNFEGPQISADIINAQYTVETLVMAVLAGSIFS 674
                 |:.....::|           |||::      ||:..::|.| :|.|...:...|
  Fly   585 -----QRTTARTLEL-----------IIDHL------PQLKENLICA-FTTEDKALFTNA----- 621

  Fly   675 LLVGFFTGYFCGRRCHKDEDDNLPY-------------------PD---TEYEYFE-------QR 710
                  |....|..|.....|.||.                   ||   |::.:|:       .|
  Fly   622 ------TKKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVRTRNGPDLVSTDFTFFDCSTHSSCTR 680

  Fly   711 QNVNSFP---------------SSCR--------------IQQEPKLLPQVEEVTYAEPVLLPQP 746
            ...:.||               .:||              .:..|...|.:........||:.
  Fly   681 CVSSEFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSGPGFCPTINATGDGSEVLVA-- 743

  Fly   747 PPPNKMHSPKNTLRKPPMHQMHQG-PNSETLFQFQPDGYNTQQSYRGRDNFGTLRSHQVMGDNY- 809
                   ...:...|..:|.:.|. ..:..:.||..:|..|.            .:.|::||..
  Fly   744 -------GGTSKSIKVKVHIIGQFIVQTRFVCQFNIEGRVTS------------LNAQLLGDTIY 789

  Fly   810 ---------RRGDGFSTTRSV----KKAVNNTNTRNRSLGRARRQPPRHGI--VTQHRSN----- 854
                     .|....:.|.:|    .|.::|.:..:..:.|.|......||  ....:.|
  Fly   790 CDSMEFQYTSRSPNLTATFAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCS 854

  Fly   855 SPQQQQQQSQQPHSSSGSSPVMSNSSSSPAPPSSSPSPQESP---------------KNCSYIYR 904
            |....:.:.|...:..|.:..::.|...|.|...:..|:..|               ||.:.||.
  Fly   855 STNTCEVEEQCNKNKEGKTDWLNRSEICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYS 919

  Fly   905 DXLICNTKSMPLIQ 918
            ...|.....||..|
  Fly   920 GVRIAGINCMPFPQ 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	109/515 (21%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/33 (33%)
PlexA	NP_524637.2	Sema_plexin_like	75..520	CDD:200497	109/509 (21%)
		PSI	522..574	CDD:279745	15/57 (26%)
		PSI	671..>699	CDD:279745	3/27 (11%)
		PSI	830..883	CDD:279745	9/52 (17%)
		IPT_plexin_repeat1	885..977	CDD:238585	11/49 (22%)
		IPT_plexin_repeat2	978..1063	CDD:238584
		IPT	1078..1177	CDD:301692
		IPT_PCSR	1196..>1255	CDD:238337
		Plexin_cytopl	1353..1916	CDD:285529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910