DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema1a and sema6d

DIOPT Version :9

Sequence 1:	NP_001260265.1	Gene:	Sema1a / 34192	FlyBaseID:	FBgn0011259	Length:	1131	Species:	Drosophila melanogaster
Sequence 2:	NP_998164.3	Gene:	sema6d / 406272	ZFINID:	ZDB-GENE-040426-1933	Length:	898	Species:	Danio rerio

Alignment Length:	979	Identity:	281/979 - (28%)
Similarity:	435/979 - (44%)	Gaps:	191/979 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 MQVFLLLTVL-VIGNQSAWQENIRPKLYVELGPEDVLKFVGNESVVD---------HFKLVTKDG 104
            |.:.||..:| :|.:.:.:..:::|...|  |.:|...:...:.:|.         .::.:.:..
Zfish    19 MAMVLLAWLLPLITSATPFPRDLQPISVV--GLDDSYLYPSFQGLVSSNETERLGLDYQRMMRIQ 81

  Fly   105 NSLLIGARNTVF--NL--SIHDLVEQQRLVWTSPEDDTKMCLVKGKDEEACQNYIRIMVVPSPGR 165
            :.|.|.||:.||  ||  ::.:::.||.|.|.|  .|...|.|:|::.:.|.|||:::|..:...
Zfish    82 HMLYIAARDHVFVVNLTTAVDEIIPQQILTWRS--TDVSKCTVRGRNSDECYNYIKVLVPRNDET 144

  Fly   166 LFVCGTNSFRPMCNTYIISDSNYTLEATKN---GQAVCPYDPRHNSTSVLADNELYSGTVADFSG 227
            ||.||||:..|.|..|.:|    :||....   |||.||::.|.::..|.|....||.||.||..
Zfish   145 LFACGTNALNPACRNYRLS----SLEQVGQELLGQARCPFESRQSNVGVFAGGHFYSATVTDFQA 205

  Fly   228 SDPIIYRE-------PLQTEQYDSLSLNAPNFVSSFTQGDFVYFFFRETAVEFINCGKAIYSRVA 285
            ||.:|||.       .|:|.:|||..|..|:|:.:...|::|||||.|.|||....||.:|||||
Zfish   206 SDAVIYRSLGGEGRPVLRTVKYDSKWLREPHFLHAVEYGNYVYFFFSEIAVEHTAAGKVVYSRVA 270

  Fly   286 RVCKWDKGGPHRFRNR-WTSFLKSRLNCSIPGDYPFYFNEIQSASNLVEGQYGSMSSKLIYGVFN 349
            ||||.|.||..|..:| ||||||:|||||:|||..|||:.:||.:|:::    ......:.|||.
Zfish   271 RVCKNDNGGSTRVLDRHWTSFLKARLNCSVPGDTFFYFDVLQSLTNVLQ----INQRPAVVGVFT 331

  Fly   350 TPSNSIPGSAVCAFALQDIADTFEGQFKEQTGINSNWLPVNNAKVPDPRPGSC--------HNDS 406
            |.:|||||||||.|.|.||...|.|:||||...:|.|..|...:||.||||||        ::.|
Zfish   332 TQTNSIPGSAVCGFYLDDIERVFNGRFKEQKNSDSMWTAVPEEQVPKPRPGSCAGEGSASSYSSS 396

  Fly   407 RALPDPTLNFIKTHSLMDENVPAFFSQPILVRTSTIYRFTQIAVDAQIKTPGG--KTYDVIFVGT 469
            ...||..|:|||||.||:|:||:..|||::..|::.|:.|||.||    |..|  |...|:|:|:
Zfish   397 VQFPDSVLSFIKTHPLMEESVPSVNSQPLITNTASSYKLTQIVVD----TAAGPHKNRTVVFLGS 457

  Fly   470 DHGKIIKSVNAESADSADKVTSVVIEEIDVLTKSEPIRNLEIVRTMQYDQPKDGSYDDGKLIIVT 534
            :.|:::|.:.....:|:.  ||.::|:|||...:..:.. ..|..::.|:      :...|.:..
Zfish   458 EDGRVLKILTNTHTNSSH--TSQLLEDIDVFNPTRCVGE-RAVLGLELDK------EHHALFVAF 513

  Fly   535 DSQVVAIQLHRCHNDKITSCSECVALQDPYCAWDKIAGKCRSHGAPRWLEENYFYQNVATGQHAA 599
            .|.|:.:.|.|| ....|....|:...||||.|.: .|:|
Zfish   514 SSCVIRVPLSRC-AQHATCRRRCLYTHDPYCIWLR-TGRC------------------------- 551

  Fly   600 CPSGKINSKDANAGEQKGFRNDMD-----LLDS---RRQSKDQEIIDNIDKNFEGPQI-SADIIN 655
                    .|...|.:.||..|:|     |.|:   ...|...::...:|......|: .||.::
Zfish   552 --------ADMAPGFKAGFEQDIDGEQTHLFDTCTDVMSSAGSDVKSAVDSASGVKQLPDADSLS 608

  Fly   656 AQYTVETL----VMAVLAGSIFSLLVGFFTGYFCGRRCHKDEDDNLPYPDTEYEYFEQRQNVNSF 716
            ..|....|    ::|.:.|:|.|   |.....:|     :....:.|.|:....:  ...:..|.
Zfish   609 DGYHFTLLGACVLLAFVLGAIAS---GLLVSCYC-----RQSSPSTPEPEATLAH--THAHTLSL 663

  Fly   717 PSSCRIQQEPKLLPQVEEVTYAEPVLLPQPPPPNKMHSPKNTLRKP--PMHQMHQGPNSETLFQF 779
            .|..:|.                  ||....|..|..||...:..|  |..::...|:|......
Zfish   664 SSLAKIN------------------LLMDNKPEKKSESPSAHIYSPAKPPEELPPTPDSTPELPI 710

  Fly   780 QPDGYNTQQSYRGRDNFGTL------RSHQVMGDNY--------RRGDGFSTTRSVKKAVNNT-- 828
            :.....:.|..|...:..||      :||.::.:|:        :|.|....:.:..|:.|.|
Zfish   711 KNIKAISSQWERSHTHNSTLQLIPTNQSHPMLSENHSDDISSSSQRFDATLMSPAGLKSYNRTLL 775

  Fly   829 ----------NTRNRSLGRARRQP--PRHGIVTQHRSNSPQQQQQQSQQPHSSSGS-----SPVM 876
                      .:...:|.:...||  .||.::......:..:|...:.:.:|::|:     .|::
Zfish   776 PKSYYSCLKEPSECSTLQQIPEQPSAQRHVLIKMGNGITSARQHTFNPKMNSNTGNIYEIQRPLV 840

  Fly   877 SNSSSSPAPPSSSPSPQESPKNCSYIYRDXLICNTKSMPLIQAQSTHAQPHPQSHPHPLPPPGPT 941
            :..|......|.|..||        :.|..::..|.|:            .||..|.||..|..|
Zfish   841 AGGSCLTRQHSYSEPPQ--------LQRSAIVRRTASL------------KPQIPPKPLNIPAKT 885

  Fly   942 TPPA 945
            .|.|
Zfish   886 LPSA 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema1a	NP_001260265.1	Sema_1A	91..546	CDD:200498	187/488 (38%)
Sema1a	NP_001260265.1	PSI	545..>579	CDD:214655	11/33 (33%)
sema6d	NP_998164.3	Sema	64..523	CDD:301699	185/481 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	318	1.000	Domainoid score	I1228
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	349	1.000	Inparanoid score	I2257
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6502
orthoMCL	1	0.900	-	-		OOG6_101616
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X415
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820